Peripheral T-cell lymphoma presenting as a solitary vermian mass

Demetriades, AK; McEvoy, AW; Galloway, Malcolm; Kitchen, ND

doi:10.1080/02688690310001613880

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…[ 13 , 19 , 37 ] Molecular assays for T-cell receptor γ chain gene rearrangement can aid in the diagnosis of T-cell PCNSL in cases with equivocal morphologic and phenotypic abnormalities. [ 12 , 13 , 23 , 30 , 37 ]…”

Section: Discussionmentioning

confidence: 99%

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Primary peripheral T-cell central nervous system lymphoma

Bird

Traylor

Thomas

et al. 2021

Surgical Neurology International

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Background: Primary peripheral T-cell central nervous system lymphoma (PCNSL) is a rare, aggressive tumor that arises in the craniospinal axis and has an increased risk in individuals who are immunocompromised. This lesion often mimics other benign and malignant processes on radiographic imaging, leading to misdiagnosis and delays in treatment. We present a case of a patient with a history of Sjögren’s syndrome and progressive neurologic symptoms who underwent craniotomy for diagnosis. Case Description: A 61-year-old woman with a history of Sjögren’s syndrome, progressive aphasia, left facial droop, and right-sided paresthesias for 4 months presented for evaluation and management. An enhancing, infiltrative lesion in the left frontal lobe with underlying vasogenic edema was appreciated and suggestive of a primary or metastatic neoplasm. The patient underwent an open biopsy for further evaluation of the lesion. Extensive histopathologic evaluation revealed a diagnosis of T-cell PCNSL. The patient was started on induction methotrexate and temozolomide followed by consolidative radiotherapy. Conclusion: Autoimmune conditions are a risk factor for T-cell PCNSL development. T-cell PCNSL has radiographic and gross histologic features that are consistent with a broad differential, including gliomas and inflammatory processes. Prompt diagnosis and extensive histopathological evaluation is essential to ensure appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

“…T-cell PCNSL has a poor prognosis. [ 12 ] In a review of 45 patients with T-cell PCNSL, Shenkier et al . (2005) found that median progression-free survival was 22 months and overall survival was 25 months.…”

Section: Discussionmentioning

confidence: 99%

Primary peripheral T-cell central nervous system lymphoma

Bird

Traylor

Thomas

et al. 2021

Surgical Neurology International

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Primary peripheral T-cell lymphoma, not otherwise specified, of the central nervous system in a child

et al. 2015

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Primary peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is a rare disease that infrequently involves the central nervous system (CNS), and it is even rarer in pediatric patients. Here, we report of a 13-year-old male with primary CNS PTCL-NOS who exhibited a malignant clinical course with recurrence after radiochemotherapy followed by bone marrow transplantation; he died 43 months after diagnosis. Pathology revealed the proliferation of cytotoxic T-cells and clonal T-cell receptor gene rearrangements. Although the optimal therapy for PTCL remains controversial, intensive radiochemotherapy may be required for some patients.

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Peripheral T-cell lymphoma presenting as a solitary vermian mass

Cited by 2 publications

References 2 publications

Primary peripheral T-cell central nervous system lymphoma

Primary peripheral T-cell central nervous system lymphoma

Primary peripheral T-cell lymphoma, not otherwise specified, of the central nervous system in a child

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