Peripheral venous distension elicits a blood pressure raising reflex in young and middle-aged adults

Matthews, Evan L.; Michael, Brian; Coyle, Dana E.; Edwards, David G.; Stocker, Sean D.; Wenner, Megan M.; Farquhar, William B.

doi:10.1152/ajpregu.00438.2015

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…Another aspect to be considered involves the fact that venous distension-induced pain may contribute to the pressor and neural responses observed in this study. In contrast to others (10,28), in our study, participants reported, on average, mild to moderate pain during saline infusion, suggesting that nociception may contribute to the magnitude of pressor and neural responses to venous distension. However, a similar level of pain was observed between the groups, minimizing its influence on the findings of the study.…”

Section: Discussioncontrasting

confidence: 99%

“…On the other hand, women presented a positive chronotropic effect in the postinfusion period. The HR behavior has similarly been described in previous studies (8,28) and indicates that chronotropic changes may be evoked via mechanical activation of type III and IV venous afferents (19). Similarly, a positive inotropic effect was observed in both groups, as indicated by an increase in CO.…”

Section: Discussionsupporting

confidence: 83%

“…Previous studies have indicated that peripheral venous distension reflexively evokes pressor and sympathetic responses (8,10,28) via mechanical stimulation of type III and IV afferents, located on the adventitia of peripheral veins. These neural and hemodynamic adjustments possibly contribute to orthostatic tolerance since a considerable amount of blood is translocated from the thoracic region to lower limbs and pelvic-abdominal region during orthostasis (33,41).…”

Section: Discussionmentioning

confidence: 99%

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Muscle sympathetic nerve activity and hemodynamic responses to venous distension: does sex play a role?

Mansur

Campos

Mattos

et al. 2019

American Journal of Physiology-Heart and Circulatory Physiology

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Peripheral venous distension mechanically stimulates type III/IV sensory fibers in veins and evokes pressor and sympathoexcitatory reflex responses in humans. As young females have reduced venous compliance, smaller increases in arterial pressure to type III/IV sensory fibers activation and impaired sympathetic transduction, we tested the hypothesis that pressor and sympathoexcitatory responses to venous distension may be attenuated in women compared to men. Mean arterial pressure (MAP, photoplethysmography), heart rate (HR), stroke volume (SV, Modelflow), cardiac output (CO = HR x SV), muscle sympathetic nerve activity (MSNA), femoral artery blood flow and conductance (FABF and FACT, Doppler ultrasound) were quantified in 8 males (27 ± 4 yrs.) and 9 females (28 ± 4 yrs.) before (CON) during (INF) and after (Post‐INF) a local infusion of normal saline (5% of the forearm volume) through a retrograde catheter inserted into an antecubital vein of the forearm, to which venous drainage and arterial supply had been occluded. MAP increased during and after infusion in both groups (vs. CON, p ≤ 0.05) but women showed a smaller pressor response in the Post‐INF period (Δ+7.2 ± 2.0 vs. men Δ+18.3 ± 3.9 mmHg, p = 0.019). MSNA increased and FACT decreased similarly in both groups (vs. CON, p ≤ 0.05) at Post‐INF. While HR changes were similar, increases in SV (Δ+20.4 ± 8.6 vs. Δ+2.6 ± 2.7 mL, p = 0.05) and CO (Δ+0.84 ± 0.17 vs. Δ+0.34 ± 0.10 L/min, p = 0.024) were greater in men than women. Therefore, these findings indicate that venous distension evokes a smaller pressor response in young women due to attenuated cardiac adjustments rather than to reduced venous compliance or sympathetic transduction. Support or Funding Information Support: CNPq, CAPES, FAPERJ This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Muscle sympathetic nerve activity and hemodynamic responses to venous distension: does sex play a role?

Mansur

Campos

Mattos

et al. 2019

American Journal of Physiology-Heart and Circulatory Physiology

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“…Data were analyzed with LabChart 7 software (ADInstruments, Colorado Springs, Colorado, USA), or exported from LabChart and analyzed with a custom designed LabVIEW program (Matthews et al, 2016). This custom LabVIEW program was used to extract synchronized beat-by-beat data of MSNA, blood pressure, and ECG R-wave time.…”

Section: Methodsmentioning

confidence: 99%

“…The MSNA signal was analyzed offline using a custom LabVIEW program as done previously (Matthews et al, 2016). This program identifies MSNA bursts by an R-wave gating approach.…”

Section: Methodsmentioning

confidence: 99%

Blood pressure responses to dietary sodium: Association with autonomic cardiovascular function in normotensive adults

Matthews

Michael

Edwards

et al. 2017

Autonomic Neuroscience

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Blood pressure responses to dietary sodium vary widely person-to-person. Salt sensitive rodent models display altered autonomic function, a trait thought to contribute to poor cardiovascular health. Thus, we hypothesized that increased salt sensitivity (SS) in normotensive humans would be associated with increased muscle sympathetic nerve activity (MSNA), decreased high frequency heart rate variability (HF-HRV), and decreased baroreflex sensitivity. Healthy normotensive men and women completed 1 week of high (300 mmol•day−1) and 1 week of low (20 mmol•day−1) dietary sodium (random order) with 24hr mean arterial pressure (MAP) assessed on the last day of each diet to assess SS. Participants returned to the lab under habitual sodium conditions for testing. Forty-two participants are presented in this analysis, 19 of which successful MSNA recordings were obtained (n=42: age 39±2 yrs, BMI 24.3±0.5 kg•(m2)−1, MAP 83±1 mmHg, habitual urine sodium 93±7 mmol•24 h−1; n=19: MSNA burst frequency 20±2 bursts•min−1). The variables of interest were linearly regressed over the magnitude of SS. Higher SS was associated with increased MSNA (burst frequency: r=0.469, p=0.041), decreased HF-HRV (r=−0.349, p=0.046), and increased LF/HF-HRV (r=0.363, p=0.034). SS was not associated with sympathetic or cardiac baroreflex sensitivity (p>0.05). Multiple regression analysis accounting for age found that age, not SS, independently predicted HF-HRV (age adjusted no longer significant; p=0.369) and LF/HF-HRV (age adjusted p=0.273). These data suggest that age-related salt sensitivity of blood pressure in response to dietary sodium is associated with altered resting autonomic cardiovascular function.

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Cardiovascular Responses to Skeletal Muscle Stretching: “Stretching” the Truth or a New Exercise Paradigm for Cardiovascular Medicine?

Kruse

Scheuermann

2017

Sports Med

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Stretching is commonly prescribed with the intended purpose of increasing range of motion, enhancing muscular coordination, and preventing prolonged immobilization induced by aging or a sedentary lifestyle. Emerging evidence suggests that acute or long-term stretching exercise may modulate a variety of cardiovascular responses. Specifically, at the onset of stretch, the mechanical deformation of the vascular bed coupled with stimulation of group III muscle afferent fibers initiates a cascade of events resulting in both peripheral vasodilation and a heart rate-driven increase in cardiac output, blood pressure, and muscle blood flow. This potential to increase shear stress and blood flow without the use of excessive muscle energy expenditure may hold important implications for future therapeutic vascular medicine and cardiac health. However, the idea that a cardiovascular component may be involved in human skeletal muscle stretching is relatively new. Therefore, the primary intent of this review is to highlight topics related to skeletal muscle stretching and cardiovascular regulation and function. The current evidence suggests that acute stretching causes a significant macro- and microcirculatory event that alters blood flow and the relationship between oxygen availability and oxygen utilization. These acute vascular changes if performed chronically may result in improved endothelial function, improved arterial blood vessel stiffness, and/or reduced blood pressure. Although several mechanisms have been postulated, an increased nitric oxide bioavailability has been highlighted as one promising candidate for the improvement in vessel function with stretching. Collectively, the evidence provided in this review suggests that stretching acutely or long term may serve as a novel and alternative low intensity therapeutic intervention capable of improving several parameters of vascular function.

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Peripheral venous distension elicits a blood pressure raising reflex in young and middle-aged adults

Cited by 8 publications

References 35 publications

Muscle sympathetic nerve activity and hemodynamic responses to venous distension: does sex play a role?

Muscle sympathetic nerve activity and hemodynamic responses to venous distension: does sex play a role?

Blood pressure responses to dietary sodium: Association with autonomic cardiovascular function in normotensive adults

Cardiovascular Responses to Skeletal Muscle Stretching: “Stretching” the Truth or a New Exercise Paradigm for Cardiovascular Medicine?

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