Peripherally Inserted Central Catheter-Related Vein Thrombosis in Patients With Lung Cancer

Kang, Junren; Li, Long; Yan, Sun; Wang, Wei; Jun, Han Zhi; Chen, Wei

doi:10.1177/1076029615595880

Cited by 37 publications

(27 citation statements)

References 39 publications

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“…In the present study, the incidence of complications per 1000PDs in the Gr and Ar1 groups may be higher than previously reported (1,9,10). As shown in Figure 1, the PICC-inserted period in some patients in the present study was relatively long (more than 50 days), and few complications occurred in these patients.…”

Section: Discussioncontrasting

confidence: 54%

Effectiveness of Synthetic Polymer-coated Peripherally Inserted Central Catheter in Patients With Advanced Cancer

Takezawa¹,

Izumi²,

Kamijima³

et al. 2019

In Vivo

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Background/Aim: A peripherally inserted central catheter (PICC) is recommended for the safe administration of anticancer agents. The effectiveness of synthetic polymercoated and non-coated PICCs was compared. Patients and Methods: Patients with advanced cancers who had indwelling PICCs were reviewed using their medical records. Three types of PICCs were compared in terms of complications and catheter failure. Results: A total of 90 patients were retrospectively analyzed, including 31 with Groshong PICCs, 30 with Argyle PICC kit, and 29 with Argyle PICC kit II. The incidence of catheter failure for Groshong PICC, Argyle PICC kit, and Argyle PICC kit II per 1,000 PICC days was 4.4614, 5.6617, and 0.8658, respectively. Catheter failure-free survival in the Argyle PICC kit II group was significantly better than that in the Argyle PICC kit group (p=0.0339). Conclusion: Argyle PICC kit II, a synthetic polymer-coated PICC, may render longer patency and prevention of catheter failure than non-coated PICCs.

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Section: Discussioncontrasting

confidence: 54%

Effectiveness of Synthetic Polymer-coated Peripherally Inserted Central Catheter in Patients With Advanced Cancer

Takezawa¹,

Izumi²,

Kamijima³

et al. 2019

In Vivo

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“…Older patients with lung cancer are susceptible to multiple risk factors for PE, including (1) patient-related factors such as advanced age, immobilization, hyperglycemia, hyperlipidemia, and smoking 18 ; (2) malignant cell-related factors 19 , including the production of procoagulant, fibrinolytic, and proaggregating conditions; release of proinflammatory and proangiogenic cytokines; and interaction with vascular and blood cells; (3) treatment-related factors such as radiotherapy 20 , chemotherapy 21 , surgery 22 , and central venous catheterization 23 ; and (4) complications 24 such as infection, heart failure, renal disease, and pulmonary disease. Therefore, to the risk of PE should be considered in older patients with a malignancy.…”

Section: Discussionmentioning

confidence: 99%

Prognosis and risk factors in older patients with lung cancer and pulmonary embolism: a propensity score matching analysis

Liu

Wang

Yuan

et al. 2020

Sci Rep

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older patients, especially those with malignancy, may have an increased risk of pulmonary embolism (pe). However, few studies have evaluated the clinical characteristics and prognosis of older patients. We evaluated the clinical characteristics, prognosis, and risk factors in older patients with lung cancer complicated with pe. this was a single-center, prospective cohort study. older patients (≥65 years) with lung cancer admitted in Beijing Hospital from January 2006 to December 2016 were enrolled. The patients were divided into two groups according to the presence of pe using propensity score matching (PSM). After PSM, one hundred and six patients (53 per group) with an average age of (77.3 ± 10.9) years were enrolled. Adenocarcinoma was the most common histology in patients with PE (52.8%, n = 28), and most lung cancer patients were in stages III and IV (59.4%, n = 63). Patients with PE were stratified to low risk (52.8%, n = 28), intermediate-low risk (24.5%, n = 13), intermediate-high risk (15.1%, n = 8), high-risk (7.5%, n = 4) subgroups. Most PE patients presented with dyspnea (75.5%), and the majority of patients (86.8%, n = 46) developed PE within 3 months after the diagnosis of cancer. The median follow-up time was 23.7 months (12.0-62.0 months), and 7 patients (6.6%) were lost to follow-up. During the follow-up period, 92 patients (86.8%) died, including 8 cases (8.7%) of PE-related death, 73 (79.3%) of tumor death, and 11 (11.9%) of unknown cause. There were significant differences in all-cause mortality (94.3% vs. 83.0%) and PE-related mortality (15.1% vs. 0) between the PE and control groups, but the rate of tumor-related mortality (75.5% vs. 66.0%) was comparable between the groups. Among the 92 patients who died, the mortality rates at 3, 6, 12, and > 12 months after tumor diagnosis were 33.0% (33/106), 57.5% (61/106), 78.3% (83/106), and 89.6% (95/106), respectively. Kaplan-Meier survival analysis showed that the median overall survival time was significantly different between the PE and the control groups (4.3 vs. 9.2 months, P = 0.0015). Multivariate stepwise logistic regression analysis showed that age ≥ 77 years (OR = 2.58, 95%CI: 1.66-4.01), clinical stage III-IV (OR = 2.21, 95%CI: 1.03-4.74), adenocarcinoma (OR = 3.24, 95%CI: 1.75-6.00), high D-dimer (≥600 mg/L) (OR = 2.73, 95%CI: 1.25-5.96), and low partial pressure of oxygen (PaO 2 ; <75 mmHg) (OR = 2.85, 95%CI: 1.74-4.67) were independent risk factors for PE in older patients with lung cancer. Older patients with lung cancer and PE often have poor prognosis. Advanced age, clinical stage III-IV, adenocarcinoma, high D-dimer level, and low PaO 2 are independent risk factors for pe.With age, older individuals are at high risk of thromboembolic events. Cancer is an established cause of venous thrombosis 1 ; once a thrombus forms, venous thromboembolism (VTE) and even pulmonary embolism (PE) can result, leading to serious adverse events such as heart failure, respiratory failure, and sudden death. The prevalence of malignancy in patients with...

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“…Several PICC questionnaires had been reported previously (21, 26); however, there was no recognized PICC-specific HRQOL questionnaire in China and we developed a self-made questionnaire for PICC-related quality of daily life based on studies published (12–21, 26). In our self-made survey, we observed little or no pain and limitation of upper extremity activity in most cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…As there was no recognized PICC-specific HRQOL questionnaire in China, we examined PICC-related quality of daily life with a self-made questionnaire, which was developed based on studies regarding PICC complications and practices (12–20). We consulted patients and PICC nurses to ensure validity and representativeness of questions.…”

Section: Methodsmentioning

confidence: 99%

“…Peripherally inserted central venous catheters (PICCs) are widely used in cancer patients for chemotherapy, antibiotic or parenteral nutrition administration. A relatively low risk of procedure-related trauma, bleeding, bloodstream infection was reported with their use (12–14). As a venous catheter for long-term drug delivery, PICCs may develop complications or limit upper extremity activity (15–20), which can have a negative impact on patients’ physical, emotional and social status.…”

Section: Introductionmentioning

confidence: 99%

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Health-Related Quality of Life of Cancer Patients with Peripherally Inserted Central Catheter: A Pilot Study

et al. 2017

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Peripherally Inserted Central Catheter-Related Vein Thrombosis in Patients With Lung Cancer

Abstract: Patients with lung cancer harboring an advanced disease or treating with etoposide were at higher risk of PICC-UEVT.

Cited by 37 publications

References 39 publications

Effectiveness of Synthetic Polymer-coated Peripherally Inserted Central Catheter in Patients With Advanced Cancer

Effectiveness of Synthetic Polymer-coated Peripherally Inserted Central Catheter in Patients With Advanced Cancer

Prognosis and risk factors in older patients with lung cancer and pulmonary embolism: a propensity score matching analysis

Health-Related Quality of Life of Cancer Patients with Peripherally Inserted Central Catheter: A Pilot Study

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