Peripherin/
            <scp>RDS</scp>

Boesze‐Battaglia, Kathleen; Muller-Weeks, Susan

doi:10.1002/0471203076.emm1061

Wiley Encyclopedia of Molecular Medicine 2002

DOI: 10.1002/0471203076.emm1061

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Peripherin/ RDS

Kathleen Boesze‐Battaglia¹,

Susan Muller-Weeks²

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2007

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“…It modulates the mechanical properties of the membrane and affects the function of membraneassociated proteins. Recent studies have shown modulation by membrane cholesterol of such diverse membrane proteins as rhodopsin (1,2), the serotonin receptor 1A (3) and serotonin transporter 5HT1 (4), the chloride channel ClC-2 (5), several classes of potassium channels (6,7), the nicotinic acetylcholine receptor (8), and several G-protein-coupled receptors (9,10).…”

mentioning

confidence: 99%

Tuning of the Outer Hair Cell Motor by Membrane Cholesterol

Rajagopalan

Greeson

Xia³

et al. 2007

Journal of Biological Chemistry

134

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Cholesterol affects diverse biological processes, in many cases by modulating the function of integral membrane proteins. We observed that alterations of cochlear cholesterol modulate hearing in mice. Mammalian hearing is powered by outer hair cell (OHC) electromotility, a membrane-based motor mechanism that resides in the OHC lateral wall. We show that membrane cholesterol decreases during maturation of OHCs. To study the effects of cholesterol on hearing at the molecular level, we altered cholesterol levels in the OHC wall, which contains the membrane protein prestin. We show a dynamic and reversible relationship between membrane cholesterol levels and voltage dependence of prestin-associated charge movement in both OHCs and prestin-transfected HEK 293 cells. Cholesterol levels also modulate the distribution of prestin within plasma membrane microdomains and affect prestin self-association in HEK 293 cells. These findings indicate that alterations in membrane cholesterol affect prestin function and functionally tune the outer hair cell.

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mentioning

confidence: 99%

Tuning of the Outer Hair Cell Motor by Membrane Cholesterol

Rajagopalan

Greeson

Xia³

et al. 2007

Journal of Biological Chemistry

134

View full text Add to dashboard Cite

show abstract

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Peripherin/ RDS

Cited by 1 publication

References 13 publications

Tuning of the Outer Hair Cell Motor by Membrane Cholesterol

Tuning of the Outer Hair Cell Motor by Membrane Cholesterol

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