Periprostatic Adipose Tissue Microenvironment: Metabolic and Hormonal Pathways During Prostate Cancer Progression

Sacca, Paula Alejandra; Calvo, Juan

doi:10.3389/fendo.2022.863027

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…From our mass spectrometry data, we identified multiple signaling pathways that could be involved in the progression of PC, such as the ribosome, carbon metabolism, metabolic pathways, glyoxylate and dicarboxylate metabolism, and tryptophan metabolism. Multiple research groups have reported the metabolic pathways as risk factors involved in PC progression [28,29]. However, the ribosome signal-ing pathway might be a novel, unreported factor in the progression of PC.…”

Section: Discussionmentioning

confidence: 99%

Proteomics reveals MRPL4 as a high‐risk factor and a potential diagnostic biomarker for prostate cancer

Hong

Zhou

et al. 2022

Proteomics

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Through digital rectal examinations (DRE) and routine prostate-specific antigen (PSA) screening, early prostate cancer (PC) treatment has become possible. However, PC is a complex and heterogeneous disease. In vivo, cancer cells can invade adjacent tissues and metastasize to other tissues resulting in hard cures. Therefore, the key to improving PC patients' survival time is preventing cancer cells' metastasis. We used mass spectrometry to profile primary PC in patients with versus without metastatic PC. We named these two groups of PC patients as high-risk primary PC (n = 11) and low-risk primary PC (n = 7), respectively. At the same time, patients with benign prostatic hyperplasia (BPH, n = 6) were used as controls to explore the possible factors driving PC metastasis. Based on comprehensive mass spectrometry analysis and biological validation, we found significant upregulation of MRPL4 expression in high-risk primary PC relative to low-risk primary PC and BPH. Further, through research of the extensive clinical cohort data in the database, we discovered that MRPL4 could be a high-risk factor for PC and serve as a potential diagnostic biomarker. The MRPL4 might be used as an auxiliary indicator for clinical status/stage of primary PC to predict patient survival time.

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Section: Discussionmentioning

confidence: 99%

Proteomics reveals MRPL4 as a high‐risk factor and a potential diagnostic biomarker for prostate cancer

Hong

Zhou

et al. 2022

Proteomics

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“…Also common is the enhanced carcinoma cell ability to actively import fatty acids and their multimeric composites from their surroundings [ 26 , 54 , 55 , 56 , 57 , 58 ]. Finally, carcinoma cells interact with and reciprocally manipulate surrounding stromal cells to procure elevated access to the lipids these support cells can manufacture and export [ 32 , 57 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ].…”

Section: Context Of “Lipid Metabolism Resistance System” (Lmrs) Hypot...mentioning

confidence: 99%

Toward a Unifying Hypothesis for Redesigned Lipid Catabolism as a Clinical Target in Advanced, Treatment-Resistant Carcinomas

Bingham,

Zachar

2023

IJMS

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We review extensive progress from the cancer metabolism community in understanding the specific properties of lipid metabolism as it is redesigned in advanced carcinomas. This redesigned lipid metabolism allows affected carcinomas to make enhanced catabolic use of lipids in ways that are regulated by oxygen availability and is implicated as a primary source of resistance to diverse treatment approaches. This oxygen control permits lipid catabolism to be an effective energy/reducing potential source under the relatively hypoxic conditions of the carcinoma microenvironment and to do so without intolerable redox side effects. The resulting robust access to energy and reduced potential apparently allow carcinoma cells to better survive and recover from therapeutic trauma. We surveyed the essential features of this advanced carcinoma-specific lipid catabolism in the context of treatment resistance and explored a provisional unifying hypothesis. This hypothesis is robustly supported by substantial preclinical and clinical evidence. This approach identifies plausible routes to the clinical targeting of many or most sources of carcinoma treatment resistance, including the application of existing FDA-approved agents.

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“…The prostate is surrounded by a rim of adipose tissue (AT), the periprostatic adipose tissue (PPAT), whose infiltration by cancer cells is linked to a poorer prognosis. White adipose tissue (WAT) is both an energy storage place and a metabolically active endocrine organ that secretes a variety of biologically active mediators contributing to paracrine and autocrine signaling pathways [2]. The involvement of PPAT in PCa aggressiveness has been strongly suggested by several studies, via production of hormones, inflammatory mediators, or lipid transfer [3].…”

Section: Introductionmentioning

confidence: 99%

Interplay between Prostate Cancer and Adipose Microenvironment: A Complex and Flexible Scenario

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Pouillot

Mahéo

et al. 2022

IJMS

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Adipose tissue is part of the prostate cancer (PCa) microenvironment not only in the periprostatic area, but also in the most frequent metastatic sites, such as bone marrow and pelvic lymph nodes. The involvement of periprostatic adipose tissue (PPAT) in the aggressiveness of PCa is strongly suggested by numerous studies. Many molecules play a role in the reciprocal interaction between adipocytes and PCa cells, including adipokines, hormones, lipids, and also lipophilic pollutants stored in adipocytes. The crosstalk has consequences not only on cancer cell growth and metastatic potential, but also on adipocytes. Although most of the molecules released by PPAT are likely to promote tumor growth and the migration of cancer cells, others, such as the adipokine adiponectin and the n-6 or n-3 polyunsaturated fatty acids (PUFAs), have been shown to have anti-tumor properties. The effects of PPAT on PCa cells might therefore depend on the balance between the pro- and anti-tumor components of PPAT. In addition, genetic and environmental factors involved in the risk and/or aggressiveness of PCa, including obesity and diet, are able to modulate the interactions between PPAT and cancer cells and their consequences on the growth and the metastatic potential of PCa.

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Periprostatic Adipose Tissue Microenvironment: Metabolic and Hormonal Pathways During Prostate Cancer Progression

Cited by 7 publications

References 34 publications

Proteomics reveals MRPL4 as a high‐risk factor and a potential diagnostic biomarker for prostate cancer

Proteomics reveals MRPL4 as a high‐risk factor and a potential diagnostic biomarker for prostate cancer

Toward a Unifying Hypothesis for Redesigned Lipid Catabolism as a Clinical Target in Advanced, Treatment-Resistant Carcinomas

Interplay between Prostate Cancer and Adipose Microenvironment: A Complex and Flexible Scenario

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