Periprosthetic Malignancy as a Mode of Failure in Total Hip Arthroplasty

O’Shea, Kieran; Kearns, Stephen; Blaney, Anya; Murray, P.; Smyth, H.; McElwain, J. P.

doi:10.1016/j.arth.2005.11.002

Cited by 33 publications

(30 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If seen, periprosthetic malignancies are more likely to be the manifestation of a primary tumour (mostly sarcomas) rather than a metastatic disease. [1][2][3][4] There have been several reports of cases in which THR failure happened as a result of periprosthetic malignant metastasis. These include metastatic disease from the following primary malignancies: five cases of bronchogenic carcinoma, three cases of renal cell carcinoma, two cases of ovarian carcinoma and one case of breast cancer, gastric adenocarcinoma, malignant immunoblastic lymphoma, non-Hodgkin's lymphoma, hepatocellular carcinoma and prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Periprosthetic metastasis: a rare cause for prosthetic loosening

Nagy¹,

Young

Gorgees

et al. 2013

BMJ Case Reports

View full text Add to dashboard Cite

SUMMARYMalignant periprosthetic metastasis is a very rare yet important cause of painful joint arthroplasty. This study presents a case in which periprosthetic osteolysis following total hip replacement (THR) occurred as a result of metastatic mesothelioma. After a THR and revision THR, histopathology confirmed the diagnosis of metastatic mesothelioma. Primary lesion was identified using CT scan of the chest. Patient is receiving palliative chemotherapy. BACKGROUND

show abstract

Section: Discussionmentioning

confidence: 99%

“…Malignant causes of prosthetic loosening are far less common and can frequently be misinterpreted as non-malignant. [1][2][3] This study presents a case in which loosening happened as a result of periprosthetic metastatic infiltration.…”

Section: Introductionmentioning

confidence: 99%

Periprosthetic metastasis: a rare cause for prosthetic loosening

Nagy¹,

Young

Gorgees

et al. 2013

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

“…The mode of clinical presentation of the periprosthetic lymphoma was varied. Seven of the cases were discovered in the bone or wear debris adjacent to the prosthesis, causing pain, lytic bone lesions and prosthetic loosening [4,6,7,8,10,11,13]. Many of these cases provided a diagnostic challenge, with symptoms and signs mimicking other conditions such as benign joint loosening or osteomyelitis, leading to a delay in definitive treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Primary non-Hodgkin lymphoma (NHL) in association with orthopaedic metallic implants is very rare, with only 11 other reported cases in the literature (table 1) [4,5,6,7,8,9,10,11,12,13]. Of these, 2 occurred following knee arthroplasty [4,5], 6 after hip arthroplasty [6,7,8,9,10,11], and 3 in association with internal fixation devices [9,12,13].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diffuse Large B Cell Lymphoma Complicating Total Knee Arthroplasty: Case Report and Literature Review of the Association of Diffuse Large B Cell Lymphoma with Joint Replacement

Chaudhry¹,

Mather²,

Marks

et al. 2011

Acta Haematol

View full text Add to dashboard Cite

Primary lymphoma of bone is extremely rare. There are increasing reports of lymphoma arising in bone adjacent to metallic prostheses. Herein, we describe the case of a 76-year-old man who developed diffuse large B cell lymphoma in the tibia 3 years after total knee arthroplasty for osteoarthritis. A review of the literature has identified 11 other cases of lymphoma arising in the context of orthopaedic metallic implants. To our knowledge this is the first reported case of a primary lymphoma arising in bone adjacent to a knee prosthesis. Possible pathogenetic mechanisms may include chronic antigenic stimulation of lymphocytes, proliferation of EBV-infected B lymphocytes, and direct mutagenic effects of metallic ions. Further research is required to investigate this intriguing link between metallic orthopaedic prostheses and localized lymphoma.

show abstract

Primary extra-cranial meningioma following total hip replacement

et al. 2008

View full text Add to dashboard Cite

A 61-year-old man presented with pain at the left hip and decreased mobility 10 years after total hip replacement. Imaging demonstrated a large destructive expansile mass adjacent to the prosthesis. Histological analysis confirmed the presence of an extra-cranial meningioma. Primary tumours after total hip replacement are rare and include soft tissue sarcomas, bone sarcomas and lymphomas. To our knowledge, no previous cases of primary extracranial meningioma have been identified. The imaging features, histology, pathogenesis and differential diagnosis are discussed.

show abstract

Periprosthetic Malignancy as a Mode of Failure in Total Hip Arthroplasty

Cited by 33 publications

References 9 publications

Periprosthetic metastasis: a rare cause for prosthetic loosening

Periprosthetic metastasis: a rare cause for prosthetic loosening

Diffuse Large B Cell Lymphoma Complicating Total Knee Arthroplasty: Case Report and Literature Review of the Association of Diffuse Large B Cell Lymphoma with Joint Replacement

Primary extra-cranial meningioma following total hip replacement

Contact Info

Product

Resources

About