Periradicular corticosteroid infiltration for radicular pain - comparison of Diprophos and Depomedrone and ozone effects

Krahulík, David; Vaverka, Miroslav; Hrabálek, Lumir; Pohlodek, Daniel; Jablonský, Jakub; Valošek, Jan; Zapletalová, Jana

doi:10.5507/bp.2021.061

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Ozone has quite a similar set of analgesic and anti-inflammatory effects compared to corticosteroids but lacks the unfavorable side effects of the latter [49]. Although ozone may be slightly less effective according to some investigators [48], further studies should compare both agents, especially in combination with the contrast distribution assessment proposed in our work.…”

Section: Discussionmentioning

confidence: 84%

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Treatment Effect of CT-Guided Periradicular Injections in Context of Different Contrast Agent Distribution Patterns

et al. 2022

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Acutely manifesting radicular pain syndromes associated with degenerations of the lower spine are frequent ailments with a high rate of recurrence. Part of the conservative management are periradicular infiltrations of analgesics and steroids. The purpose of this study is to evaluate the dependence of the clinical efficacy of CT-guided periradicular injections on the pattern of contrast distribution and to identify the best distribution pattern that is associated with the most effective pain relief. Using a prospective study design, 161 patients were included in this study, ensuring ethical standards. Statistical analysis was performed, with the level of statistical significance set at p = 0.05. A total of 37.9% of patients experienced significant but not long-lasting (four weeks on average) complete pain relief. A total of 44.1% of patients experienced prolonged, subjectively satisfying pain relief of more than four weeks to three months. A total of 18% of patients had complete and sustained relief for more than six months. A significant correlation exists between circumferential, large area contrast distribution including the zone of action between the disc and affected nerve root contrast distribution pattern with excellent pain relief. Our results support the value of CT-guided contrast injection for achieving a good efficacy, and, if necessary, indicative repositioning of the needle to ensure a circumferential distribution pattern of corticosteroids for the sufficient treatment of radicular pain in degenerative spine disease.

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Section: Discussionmentioning

confidence: 84%

“…Recent investigations indicate that periradicular infiltrations using ozone as therapeutic agent also bear great potential [48,49]. Ozone has quite a similar set of analgesic and anti-inflammatory effects compared to corticosteroids but lacks the unfavorable side effects of the latter [49].…”

Section: Discussionmentioning

confidence: 99%

Treatment Effect of CT-Guided Periradicular Injections in Context of Different Contrast Agent Distribution Patterns

et al. 2022

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The Effectiveness of Ozone Infiltration on Patient-Reported Outcomes in Low Back Pain: A Systematic Review and Meta-Analysis

Llombart-Blanco,

Mariscal,

Cordón

et al. 2024

Life

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Background/Objective: The objective of this systematic review and meta-analysis was to evaluate the current evidence on the relative efficacy of ozone injections for improving patient-reported outcomes (PROMs). Methods: A literature search was conducted in four databases, and PROMs were analyzed. Odds ratios (ORs), mean differences, and standard mean differences with 95% confidence intervals (CI) were calculated. Meta-analysis was performed using Review Manager. Results: Nine studies (total number of participants = 1711) were included. Overall, the ODI (Oswestry Disability Index) showed favorable results for ozone (SMD −0.28, 95% CI −0.51 to −0.06). However, subgroup analysis by follow-up time found no significant differences at 2 weeks or 6 months but significant differences at 1 month. The VAS also favored ozone use overall (SMD −0.12, 95% CI −0.24 −0.01). Subgroup and sensitivity analyses revealed no significant differences between groups. There were also no significant differences in excellent outcomes (OR 0.95, 95% CI 0.54 to 1.67) or poor outcomes (OR 1.25, 95% CI 0.66 to 2.37). Conclusions: Ozone therapy has demonstrated limited benefits over the usual care for lower back pain. While a small advantage emerged for function at one month, the results were inconsistent, and no differences were seen in pain or clinical outcomes.

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Periradicular corticosteroid infiltration for radicular pain - comparison of Diprophos and Depomedrone and ozone effects

Cited by 2 publications

References 23 publications

Treatment Effect of CT-Guided Periradicular Injections in Context of Different Contrast Agent Distribution Patterns

Treatment Effect of CT-Guided Periradicular Injections in Context of Different Contrast Agent Distribution Patterns

The Effectiveness of Ozone Infiltration on Patient-Reported Outcomes in Low Back Pain: A Systematic Review and Meta-Analysis

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