Peritoneal Dialysis Reduces Intraperitoneal Adhesion Formation

Abstract

The preventive effect of 24 h intermittent peritoneal dialysis on intra-abdominal adhesion formation was investigated in rats. Intraperitoneal adhesions were induced by excision of 1 × 3 cm of the peritoneum and underlying muscle, subsequently closed with interrupted silk sutures. Animals were allocated at random to either postoperative peritoneal dialysis or a control group. Quantitative assessment of adhesions 1 week later showed a significant reduction in rats undergoing peritoneal dialysis (p < 0.01).

Spray of Phospholipid Powder Reduces Peritoneal Adhesions in Rabbits

“…Intermittent peritoneal dialysis performed over a 24‐h period reduces adhesion formation in rats 20 . The mechanisms postulated are either removal of fibrin or other adhesion‐promoting substances from the area of injury or mechanical disruption of initial flimsy adhesions.…”

Semisoluble aminated glucan: Long-term efficacy against an intraperitonealE. coli challenge and its effect on formation of abdominal adhesions

“…The created defect was closed with 6 (5 mm apart) atraumatic 3/0 single silk sutures. This procedure is essentially as described by Gilmore and Reid [11] and later modified by others [15]. After closure of the abdominal incision in two layers the rats were randomly allocated to either treatment with 10ml SAG (50mg) i.p.…”

“…The part of the defect having adhesions attached was measured in millimeters as in the original model [11,15].…”

“…Testing of this hypothesis was the second aim of this study. A reliable rat model, initially described by Gilmore and Reid [11] and modified by Lindenberg et al [15] was used, allowing a quantitative assessment of the anti-adhesive effect of SAG.…”