“…These changes in horses with nonstrangulating GIT obstruction contrast with the results of a study 20 in which circulating neutrophils from horses with this type of GIT disease were not activated. However, the findings of the present study were consistent with the results of another study 33 in which experimentally induced intraluminal colonic obstruction caused damage to the GIT mucosa and induced inflammatory lesions in remote organs. Furthermore, evidence of the activation of circulating leukocytes in horses with naturally occurring nonstrangulating obstruction has been reported.…”
“…These changes in horses with nonstrangulating GIT obstruction contrast with the results of a study 20 in which circulating neutrophils from horses with this type of GIT disease were not activated. However, the findings of the present study were consistent with the results of another study 33 in which experimentally induced intraluminal colonic obstruction caused damage to the GIT mucosa and induced inflammatory lesions in remote organs. Furthermore, evidence of the activation of circulating leukocytes in horses with naturally occurring nonstrangulating obstruction has been reported.…”
“…Arterial low-flow ischemia contrasts with models in which complete ischemia is produced and is intended to model intestinal disorders (eg, severe intestinal distension and conditions that develop at the periphery of strangulating lesions) in which partial arterial obstruction is thought to develop. [19][20][21][22] We hypothesized that arterial low-flow ischemia would increase COX-2 gene expression in the jejunum of horses and that expression of traditional housekeeping genes would not remain stable under these experimental conditions.…”
Low-flow ischemia resulted in upregulation of COX-2 gene expression in the jejunum of horses. Housekeeping genes traditionally used as internal standards may not be stable in this tissue during arterial low-flow ischemia and reperfusion.
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