Peritoneal Psammocarcinoma Diagnosed by a Papanicolau Smear

Riboni, Francesca; Giana, Michele; Piantanida, Paola; Vigone, Alessandro; Surico, N; Boldorini, Renzo

doi:10.1159/000325040

Cited by 8 publications

(16 citation statements)

References 4 publications

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“…In Psammocarcinoma, it has been reported that small sand grains, psammoma bodies, were detected by preoperative cervical cytology, ascites cytology or intraoperative abdominal washing cytology, and tumor imprinting cytology. [7][8][9] Although no sand granules were found on any cytological specimen in this case, tumor-imprinting cytology exhibited the cell clusters of low grade serous carcinoma, which may help in the diagnosis of psammocarcinoma. Gilks The present case also met all four of these criteria and was diagnosed as psammocarcinoma.…”

Section: Discussionmentioning

confidence: 62%

Primary ovarian serous psammocarcinoma-a case report with mini literature review

Baba¹,

Fukagawa²,

Itamochi³

et al. 2020

OGIJ

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Serous psammocarcinoma is a rare subtype of serous carcinoma in which a significant number of psammoma bodies are present histologically. Because it is an extremely rare disease, the pathogenesis of the disease remains unclear. Here we present a case of primary ovarian serous psammocarcinoma in which computed tomography (CT) imaging of the abdomen was useful for the diagnosis. A female patient was referred to our department with a complaint of abdominal distention. Pelvic magnetic resonance imaging revealed a multifocal tumor with a papillary enhancement in the right appendicular region, and abdominal CT imaging exhibited marked calcification of the enhancement. She underwent a laparotomy for suspected right ovarian cancer. As postoperative pathological examination revealed dominant stromal infiltration of psammoma bodies beneath peritoneum, this case was diagnosed as primary ovarian serous psammocarcinoma at FIGO Stage IIB. The patient was treated with six courses of paclitaxel plus carboplat in after the surgery. She is currently under outpatient observation without any signs of recurrence after 8 years of treatment. The case of significant calcification of the intra cystic enrichment on CT imaging is considered to be a case of this disease.

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Section: Discussionmentioning

confidence: 62%

Primary ovarian serous psammocarcinoma-a case report with mini literature review

Baba¹,

Fukagawa²,

Itamochi³

et al. 2020

OGIJ

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show abstract

“…It is noteworthy that psammoma bodies, in relation to female reproductive organs, may also be present in peritoneal mesothelial hyperplasia [ 4 ], cervical polyps, endometriosis, and endosalpingiosis [ 18 ]; in addition to the serous neoplastic lesions [ 19 , 20 ]. Although presence of psammoma bodies appears to be rare in adenomatoid tumors of male and female reproductive organs, we failed to find any reference to that effect in our extensive search of PubMed and Google.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Adenomatoid Tumor of Fimbria with Pronounced Psammoma Bodies in a BRCA Positive Patient as a Pitfall for Carcinoma on Frozen Section

Lee

Moh

Sullivan

et al. 2018

Case Reports in Pathology

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Background BRCA gene mutations significantly increase the risk of breast and ovarian cancers where the lifetime risk of the ovarian cancer is about 40%. Therefore, many women with such mutations undergo prophylactic bilateral mastectomy and salpingo-oophorectomy. About 5-6% of these individuals display occult carcinomas in tubo-ovarian locations of which over 85% are tubal in origin. The objective of this case study was to emphasize emergence of benign lesions mimicking cancer under these circumstances. Case Report We present a case with positive BRCA1 mutation who underwent the prophylactic procedure where a small mass was identified in her fallopian tube. Our initial encounter with this tumor was during intraoperative consultation. The tumor was associated with extensive psammoma bodies arranged in closely packed small tubules, mimicking serous carcinoma. Frozen section limitations including artifact, time constraint, and lack of ancillary studies as well as the clinical history further complicated our diagnostic assessment, which was deferred. A diagnosis of adenomatoid tumor was rendered on permanent sections. Conclusion It is important to be familiar with this morphologic presentation of adenomatoid tumor as it is a pitfall for carcinoma, particularly on frozen section, and inaccurate diagnosis could lead to further unnecessary extensive procedures.

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“…An asymptomatic, abdominal skin lesion that led to the diagnosis of PPSC was described by Cowan et al in 1995. 3 Another patient was diagnosed as having PPSC by a video-assisted thoracoscopic surgery due to bilateral pleural masses 4 , while three cases of PPSC [5][6][7] and one of serous peritoneal psammocarcinoma 8 were diagnosed by abnormal cytology ( Table 1). We report the fourth case of PPSC detected by abnormal cervical cytology, which is the first one with an absence of ovarian and tubal tissue at the time of the diagnosis.…”

Section: Cmentioning

confidence: 99%

Primary Peritoneal Serous Carcinoma Detected by Abnormal Cervical Smear: a Case Report

Blontzos

Iavazzo

Giovannopoulou

et al. 2020

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Primary peritoneal serous carcinoma (PPSC) is a rare malignancy, the clinical characteristics of which resemble ovarian serous carcinoma. We present a rare case of PPSC detected by an abnormal cervical smear, the first one with an absence of ovarian tissue at the time of the initial diagnosis. A 59-year-old asymptomatic woman presented with glandular atypia on routine Papanicolaou smear. Endocervical and endometrial curettage showed an adenocarcinoma with focal squamous differentiation and uncertain further classification. The patient had a past surgical history of bilateral salpingoophorectomy due to endometriosis. Abdominal MRI depicted omental multinodularity, great amount of ascites and possible endometrial tumor. The patient underwent total hysterectomy, omentectomy and biopsies of implants on Douglass pouch.  Surgical and histological findings were consistent with primary peritoneal serous carcinoma.  Abnormal pap smear could rarely be suggestive of extrauterine malignancies, such as peritoneal cancer.

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Peritoneal Psammocarcinoma Diagnosed by a Papanicolau Smear

Cited by 8 publications

References 4 publications

Primary ovarian serous psammocarcinoma-a case report with mini literature review

Primary ovarian serous psammocarcinoma-a case report with mini literature review

An Unusual Adenomatoid Tumor of Fimbria with Pronounced Psammoma Bodies in a BRCA Positive Patient as a Pitfall for Carcinoma on Frozen Section

Primary Peritoneal Serous Carcinoma Detected by Abnormal Cervical Smear: a Case Report

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