Periumbilical Perforating Pseudoxanthoma Elasticum

Somasundaram, V.; Premalatha, S.; Rao, Nagarathna; Razack, E. M. Abdul; Zahra, Asfa

doi:10.1111/j.1365-4362.1987.tb02297.x

Cited by 15 publications

(7 citation statements)

References 5 publications

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“…That is why some authors suggest that it is an acquired localized form seperated from hereditary PXE. [3,5,6] Other cases are reported to have angioid streaks and flexural lesions that are suggestive of hereditary systemic PXE. [2,7,8] Several patients had accompanying hypertension and diabetes; [2][3][4]6,7,[9][10][11][12] it is well known that cardiovascular involvement of PXE may lead to renovascular hypertension, and diabetes may also be associated with PXE.…”

Section: Discussion Discussionmentioning

confidence: 99%

“…Of these, 12 were African-American (54%), 17 were multiparous (72%), 14 had hypertension (63%) and 4 had chronic renal failure (18%). [1,5,6,9,12] Moreover, with regard to the available literature, 4 of them had flexural lesions (18%), whereas 5 had angioid streaks (only 2 of them confirmed with fundus angiography) (22%). [2,7,8] The repeated trauma of pregnancy, obesity and/or abdominal surgery may result in elastic fiber degeneration in these patients.…”

Section: Discussion Discussionmentioning

confidence: 99%

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Periumbilical perforating pseudoxanthoma elasticum

Kocatürk¹,

Kavala²,

Zindancı³

et al. 2009

Indian J Dermatol Venereol Leprol

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A 58-year-old, gravida 6, obese woman presented with a pruritic yellowish plaque around the umbilicus, which first appeared about 3 years ago. She also had flat yellow papules on the axilla and neck. After a burn from a heating device, a few perforating papules and a violaceous hue occurred on the plaque. Histological examination revealed pathological elastic fibers with a keratotic plug and perforation in the deep dermis, which was consistent with perforating pseudoxanthoma elasticum. This case indicates that perforating pseudoxanthoma elasticum, a variant of hereditary pseudoxanthoma elasticum may perforate due to mechanical factors.

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Section: Discussion Discussionmentioning

confidence: 99%

Section: Discussion Discussionmentioning

confidence: 99%

Periumbilical perforating pseudoxanthoma elasticum

Kocatürk¹,

Kavala²,

Zindancı³

et al. 2009

Indian J Dermatol Venereol Leprol

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show abstract

“…84,87,91 The perforating subtype of acquired PXE has been reported predominantly in the periumbilical area of multiparous women and in patients with severe ascites or a history of abdominal surgery, which suggests that mechanical stress may be important in the pathogenesis. 89,[92][93][94] It has also been reported in patients with dialysis-dependent chronic renal failure, suggesting that abnormal calciumphosphate metabolism leading to hyperphosphatemia may be a risk factor, although this hypothesis has not been systematically studied. 95 Clinical manifestations.…”

Section: Elastosis Perforans Serpiginosamentioning

confidence: 91%

Acquired disorders of elastic tissue: part I. increased elastic tissue and solar elastotic syndromes

Lewis

Bercovitch

Dill

et al. 2004

Journal of the American Academy of Dermatology

173

178

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“…Perforating PXE (perforating calcific elastosis) usually is localized to the periumbilical region and lacks systemic involvement. Predisposing factors for the development of perforating PXE may be obesity or multiple pregnancies . The condition appears to represent a degenerative change within abdominal striae.…”

Section: Evg Staining In Primary Elastic Tissue Disordersmentioning

confidence: 99%

The utility of elastic Verhoeff‐Van Gieson staining in dermatopathology

et al. 2012

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Elastic fibers are important components of the skin and are responsible for skin elasticity. Genetic defects are well-known in numerous hereditary elastic tissue disorders and skin biopsies are often the first step in the evaluation of those disorders. Verhoeff-Van Gieson elastic staining is a simple method that is used for visualizing elastic fibers. With the development of modern immunohistochemical methods, the value of routine histochemical staining is sometimes underestimated. Histochemical stains are less expensive, easy to perform and help to resolve numerous diagnostic quandaries in dermatopathology. This article focuses on the value of elastic tissue staining in dermatopathology, with a focus on primary elastic tissue disorders, alopecia, inflammatory skin disorders and neoplastic proliferations. Connective tissue comprises of three types of fibers: collagen fibers, reticular fibers and elastic fibers. These fibers are made of proteins and composed of long peptide chains. While the main function of collagen and reticular fibers is to provide tensile strength and support respectively, the elastic fibers are mainly there for providing stretchability and flexibility. Elastic fibers can stretch up to 1.5 times their length, and snap back to their original length when relaxed. The long and branching arrangement of fibers enables them to stretch and recoil thus providing flexibility to tissues. Elastic fibers are composed of two structural components: elastin and microfibrils, and include elastin, elaunin and oxytalan.

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Periumbilical Perforating Pseudoxanthoma Elasticum

Cited by 15 publications

References 5 publications

Periumbilical perforating pseudoxanthoma elasticum

Periumbilical perforating pseudoxanthoma elasticum

Acquired disorders of elastic tissue: part I. increased elastic tissue and solar elastotic syndromes

The utility of elastic Verhoeff‐Van Gieson staining in dermatopathology

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