Perivascular adipose-derived exosomes reduce macrophage foam cell formation through miR-382-5p and the BMP4-PPARγ-ABCA1/ABCG1 pathways

Liu, Yan; Sun, Yan; Lin, Xuze; Zhang, Dai; Hu, Chengping; Liu, Jin-Xing; Zhu, Yong; Gao, Ang; Han, Hongya; Chai, Meng; Zhang, Jianwei; Zhao, Yingxin; Zhou, Yujie

doi:10.1016/j.vph.2022.106968

Cited by 34 publications

(24 citation statements)

References 30 publications

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“…Specifically, sEVs have been linked with the development of microcalcification in atherosclerotic plaques, as calcified sEV aggregates were identified between collagen fibers, forming calcifying structures [ 72 ]. Along the same lines, Liu et al [ 73 ] demonstrated that sEVs released from perivascular adipose tissue carry miR-382-5p, which regulate the cholesterol efflux transporters ABCA1 and ABCG1, reducing macrophage foam cell formation. Although these results are very promising, as a means to prevent atherosclerosis, more work needs to be done to confirm the findings and possibly assess their anti-atherogenic effect in an in vivo model.…”

Section: Potential Role Of Sevs In Cvd Pathogenesis and Diagnosismentioning

confidence: 98%

A Novel, Cell-Free Therapy to Enter Our Hearts: The Potential Role of Small EVs in Prevention and Treatment of CVD

Λαζανά

Anagnostopoulos

2022

IJMS

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Heart disease constitutes one of the leading causes of morbidity and mortality worldwide. Current therapeutic techniques, such as interventional revascularization, although lifesaving, come along with myocardial injury related to the reperfusion itself, called ischemia-reperfusion injury, which is an added factor for increased morbidity. For that reason, there is an imperative need for novel therapies to be developed that would either prevent or treat myocardial injury. Extracellular vesicles (EVs), specifically small EVs (sEVs), have proven to be important mediators of intercellular communication. The fact that they carry information reflecting that of the parental cell makes them an ideal candidate for diagnostic purposes. sEVs derived from immunoregulatory cells, such as mesenchymal stem cells or cardiac progenitor cells, could also be used therapeutically to exert the primary immunomodulatory function but without carrying the side effects related to cell therapy. Furthermore, as a natural product, they have the added advantage of low immunogenicity, offering the potential for safe drug delivery. In the field of cardiology, there has been great interest in the therapeutic and diagnostic potential of sEVs with significant translational potential. Here, we review the potential use of sEVs in the context of myocardial ischemia and ischemia-reperfusion injury.

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Section: Potential Role Of Sevs In Cvd Pathogenesis and Diagnosismentioning

confidence: 98%

A Novel, Cell-Free Therapy to Enter Our Hearts: The Potential Role of Small EVs in Prevention and Treatment of CVD

Λαζανά

Anagnostopoulos

2022

IJMS

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“…Although miR-382-5p upregulates the expression of the transporters, miR-30e and miR-92a downregulate their expression. The reduced levels of the efflux transporters due to the changes in microRNA levels result in the accumulation of cholesterol in macrophages promoting foam cell formation [10,63]. In hepatocytes, ABCA1 is involved in the formation of high-density lipoprotein levels (HDL), which is negatively correlated with developing atherosclerosis.…”

Section: Atherosclerosismentioning

confidence: 99%

Exosomes and lipid metabolism in metabolic and cardiovascular disorders

Abdin¹,

Geng²,

Chandy

2023

Current Opinion in Lipidology

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Purpose of reviewExosomes are lipid-bound particles that carry lipids, protein, and nucleic acid and affect cellular function. This review highlights the current knowledge on the crosstalk between exosomes and lipid metabolism and their impact on cardiometabolic disease.Recent findingsRecent studies revealed that lipids and lipid metabolizing enzymes are important for exosome biogenesis and internalization and conversely how exosomes affect lipid metabolism, secretion, and degradation. The interplay between exosomes and lipid metabolism affects disease pathophysiology. More importantly, exosomes and lipids might function as biomarkers for diagnosis and prognosis or possibly therapies.SummaryRecent advances in our understanding of exosomes and lipid metabolism have implications for our understanding of normal cellular and physiological functions as well as disease pathogenesis. Exosome and lipid metabolism have implications in novel diagnostic tests and treatments of cardiometabolic disease.

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“…Adipose tissues have been shown to produce circulating exosomal miRNAs, as a form of adipokine, to regulate gene expressions locally or distantly [ 75 ]. These miRNA-containing extracellular vesicles act as the agent for the crosstalk between adipose tissues and neighboring tissues, including endothelial cells, VSMCs, and macrophages [ 76 , 77 , 78 ]. In addition, the crosstalk between endothelial cells and adipocytes is modulated, at least partly, by the extracellular vesicles-mediated reciprocal trafficking of caveolin-1 (Cav-1) [ 79 ].…”

Section: What Is the Function Of Pvat?mentioning

confidence: 99%

“…A recent study demonstrated that PVAT secretes encapsulated microRNAs, such as miR-221-3p, which can be taken up in neighboring VSMCs, and triggers an early vascular remodeling in vascular inflammation [ 72 ]. In another recent study, PVAT-derived exosomes were demonstrated to reduce macrophage foam cell formation through miR-382-5p- and bone morphogenetic protein 4 (BMP4)-PPARγ-mediated upregulation of cholesterol efflux transporters [ 76 ]. However, it is still unclear which cell types in PVAT generate these extracellular vesicles.…”

Section: What Is the Function Of Pvat?mentioning

confidence: 99%

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue

et al. 2022

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Perivascular adipose tissue (PVAT) is a special type of ectopic fat depot that adheres to most vasculatures. PVAT has been shown to exert anticontractile effects on the blood vessels and confers protective effects against metabolic and cardiovascular diseases. PVAT plays a critical role in vascular homeostasis via secreting adipokine, hormones, and growth factors. Endothelial nitric oxide synthase (eNOS; also known as NOS3 or NOSIII) is well-known for its role in the generation of vasoprotective nitric oxide (NO). eNOS is primarily expressed, but not exclusively, in endothelial cells, while recent studies have identified its expression in both adipocytes and endothelial cells of PVAT. PVAT eNOS is an important player in the protective role of PVAT. Different studies have demonstrated that, under obesity-linked metabolic diseases, PVAT eNOS may be even more important than endothelium eNOS in obesity-induced vascular dysfunction, which may be attributed to certain PVAT eNOS-specific functions. In this review, we summarized the current understanding of eNOS expression in PVAT, its function under both physiological and pathological conditions and listed out a few pharmacological interventions of interest that target eNOS in PVAT.

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Perivascular adipose-derived exosomes reduce macrophage foam cell formation through miR-382-5p and the BMP4-PPARγ-ABCA1/ABCG1 pathways

Cited by 34 publications

References 30 publications

A Novel, Cell-Free Therapy to Enter Our Hearts: The Potential Role of Small EVs in Prevention and Treatment of CVD

A Novel, Cell-Free Therapy to Enter Our Hearts: The Potential Role of Small EVs in Prevention and Treatment of CVD

Exosomes and lipid metabolism in metabolic and cardiovascular disorders

Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue

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