Perivascular Stem Cell-Derived Cyclophilin A Improves Uterine Environment with Asherman’s Syndrome via HIF1α-Dependent Angiogenesis

Park, Soo‐Jin; Hong, Seok‐Ho; Park, So Hee; Kim, Yeon Sun; Yang, Seung Chel; Kim, Hye Ryun; Noh, Songmi; Na, Sunghun; Lim, Hyunjung Jade; Lyu, Sang Woo; Song, Haengseok

doi:10.1016/j.ymthe.2020.05.015

Cited by 23 publications

(29 citation statements)

References 64 publications

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“…We extracted 100 articles which is cited most in the eld of IUA which is listed in Table 1. Citations ranges from 30 to 253 in number, with a majority of them published in the 2010s (35 ) and 2000s (29 ). The overall trend was increasing year by year (Fig.…”

Section: Resultsmentioning

confidence: 98%

“…In order to reduce the recurrence rate of IUA and improve reproductive prognosis, it is often recommended to assist other prevention and treatment measures for comprehensive management of adhesions after the surgery (16-18). These measures mainly include devices to keep opposing endometrial surfaces separated, such as intrauterine device (IUD) (19), Foley catheter balloon (20), auto-crosslinked hyaluronic acid (ACP) gel (21)(22)(23)(24), and interventions to promote endometrial regeneration, such as estrogen (25,26), stem cell (27)(28)(29), stem cell exosome (30), amniotic epithelial cells (31), granulocyte colony stimulating factor (32), platelet rich plasma (33), aspirin (34), etc. However, current effectiveness is still not ideally.…”

Section: Introductionmentioning

confidence: 99%

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The Top 100 Most Cited Articles on Intrauterine Adhesion: A Bibliometric Analysis

2021

Preprint

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Background: Bibliometric analysis is a statistical method which attempts to assess articles by their citations, analyzing their frequency and pattern of citing phenomenon. Through the analysis, some guidance can be extracted for future research directions. Over the past few years, there have been articles published in mounting numbers focused on intrauterine adhesions. Nevertheless, little is known about the properties and qualities of these researches. No existed analysis commits to reflecting the progress of researches in intrauterine adhesion.Methods: Web of Science Core Collection, BIOSIS Citation Index and MEDLINE were searched for the identifying articles released from 1950 to October 2020. Articles concerning about Intrauterine adhesion were determined. Subsequently, the 100 most cited articles were chosen for analysis of citation count, citation density (citations/article age), authorship, theme, geographic distribution, time-related flux, level of evidence, and network analysis.Results: An overwhelming majority of the certain 100 articles were put out in the 2010s (35%). Citations per article ranged from 30 to 253. China possesses the most papers among the top 100 papers, followed by the USA, France, Israel and Italy. The study theme that most highlighted were operative hysteroscopy and adjunctive treatments for improving reproductive outcome. Level II is the most common level of evidence, and there is no statistical difference in the number of citations between the levels. The network analysis connoted that hysteroscopy, hysteroscopic adhesiolysis, infertility, and reproductive outcome had a great degree of centrality in the 2000s and 2010s, while placental implantation had a great degree of centrality in the 2000s and stem cell and fibrosis had a great degree of centrality in the 2010s. Conclusions: We conducted a bibliometric analysis of the top 100 most cited articles in the literature on intrauterine adhesions. It is worth noting that hysteroscopy and hysteroscopic adhesiolysis were long-term concern in the field of intrauterine adhesion researches. As the elapse of time, postoperative adjuvant treatment has gradually become the hot spot of researches. However, there are only 9 experimental articles among these 100 articles, showing the lack of breakthrough progress in the field of intrauterine adhesions at the mechanism level.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

The Top 100 Most Cited Articles on Intrauterine Adhesion: A Bibliometric Analysis

2021

Preprint

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“…Therefore, subsequent IUA management is considered necessary when IUA occurs. Thus far, there have been many publications addressing the topic of the management of IUA [ 23 , 24 , 26 , 27 , 28 , 29 , 30 , 35 , 40 , 43 , 57 , 58 , 59 , 62 , 64 , 131 , 132 , 133 , 134 , 135 , 136 , 138 , 139 , 140 , 141 , 142 , 155 , 164 , 165 , 166 , 167 , 168 ].…”

Section: Future Vision Of Iua Managementmentioning

confidence: 99%

Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision

Lee

Liu

Chen

et al. 2021

IJMS

108

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Intrauterine adhesion (IUA), and its severe form Asherman syndrome (Asherman’s syndrome), is a mysterious disease, often accompanied with severe clinical problems contributing to a significant impairment of reproductive function, such as menstrual disturbance (amenorrhea), infertility or recurrent pregnancy loss. Among these, its correlated infertility may be one of the most challenging problems. Although there are many etiologies for the development of IUA, uterine instrumentation is the main cause of IUA. Additionally, more complicated intrauterine surgeries can be performed by advanced technology, further increasing the risk of IUA. Strategies attempting to minimize the risk and reducing its severity are urgently needed. The current review will expand the level of our knowledge required to face the troublesome disease of IUA. It is separated into six sections, addressing the introduction of the normal cyclic endometrial repairing process and its abruption causing the formation of IUA; the etiology and prevalence of IUA; the diagnosis of IUA; the classification of IUA; the pathophysiology of IUA; and the primary prevention of IUA, including (1) delicate surgical techniques, such as the use of surgical instruments, energy systems, and pre-hysteroscopic management, (2) barrier methods, such as gels, intrauterine devices, intrauterine balloons, as well as membrane structures containing hyaluronate–carboxymethylcellulose or polyethylene oxide–sodium carboxymethylcellulose as anti-adhesive barrier.

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“…The multilineage differentiation potential of hPVCs cultured in NG and HG conditions was evaluated at passages 3 and 4 as previously described [13]. Briefly, for adipogenic differentiation, hPVCs (4 × 10 4 cells/well) were plated in 12-well tissue culture plates and cultured in adipogensis differentiation medium (A10070-01; StemPro ® , Thermo Fisher Scientific, Waltham, MA, USA) for 21 days.…”

Section: Hpvc Differentiationmentioning

confidence: 99%

Regulation of JAM2 Expression in the Lungs of Streptozotocin-Induced Diabetic Mice and Human Pluripotent Stem Cell-Derived Alveolar Organoids

Rasaei

Kim

et al. 2020

Biomedicines

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Hyperglycemia is a causative factor in the pathogenesis of respiratory diseases, known to induce fibrosis and inflammation in the lung. However, little attention has been paid to genes related to hyperglycemic-induced lung alterations and stem cell applications for therapeutic use. In this study, our microarray data revealed significantly increased levels of junctional adhesion molecule 2 (JAM2) in the high glucose (HG)-induced transcriptional profile in human perivascular cells (hPVCs). The elevated level of JAM2 in HG-treated hPVCs was transcriptionally and epigenetically reversible when HG treatment was removed. We further investigated the expression of JAM2 using in vivo and in vitro hyperglycemic models. Our results showed significant upregulation of JAM2 in the lungs of streptozotocin (STZ)-induced diabetic mice, which was greatly suppressed by the administration of conditioned medium obtained from human mesenchymal stem cell cultures. Furthermore, JAM2 was found to be significantly upregulated in human pluripotent stem cell-derived multicellular alveolar organoids by exposure to HG. Our results suggest that JAM2 may play an important role in STZ-induced lung alterations and could be a potential indicator for predicting the therapeutic effects of stem cells and drugs in diabetic lung complications.

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Perivascular Stem Cell-Derived Cyclophilin A Improves Uterine Environment with Asherman’s Syndrome via HIF1α-Dependent Angiogenesis

Cited by 23 publications

References 64 publications

The Top 100 Most Cited Articles on Intrauterine Adhesion: A Bibliometric Analysis

The Top 100 Most Cited Articles on Intrauterine Adhesion: A Bibliometric Analysis

Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision

Regulation of JAM2 Expression in the Lungs of Streptozotocin-Induced Diabetic Mice and Human Pluripotent Stem Cell-Derived Alveolar Organoids

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