Permacol™ Collagen Paste Injection in Anal Fistula Treatment: A Retrospective Study with One-Year Follow-Up

Abstract

In this study, we show that treatment of patients with an anal fistula by injection of Permacol™ is a safe and successful method that does not compromise continence.

Efficacy of Permacol injection for perianal fistulas in a tertiary referral population: poor outcome in patients with complex fistulas

“…The outcome of Permacol injection in our cohort was poor compared with other studies (summary of previous studies with a minimum of ≥10 patients; Table 3 ) [ 19 , 20 , 21 , 22 , 23 , 24 ]. The proportion of patients with healed fistulas was almost three‐fold lower than in the MASERATI100 study at 12 months follow‐up (56.7%) [ 19 ].…”

“…Other studies reported efficacy rates much like the MASERATI100 study, with a range between 47.6% and 57.0% (Table 3 ) [ 21 , 22 , 23 , 24 ]. Only one study reported a much higher healing rate of 77.4% [ 20 ]. Nevertheless, patients in our cohort were more likely to have recurrent fistulas, a higher internal opening or multiple tracts and the follow‐up period was longer than in the other studies, which might explain the difference in proportions of fistula healing.…”

“…Although unlikely given the long follow‐up period, this might overestimate the proportion of patients with a closed fistula. The primary endpoint in most other Permacol studies was also based on clinical assessment [ 19 , 20 , 21 , 22 , 24 ]. Fourthly, a larger population is needed to adjust for confounders (e.g.…”

“…The MASERATI100 study showed a healing rate of 53.5% in a large population of patients with primary or recurrent fistulas at 12 months follow‐up [ 19 ]. To date, only a small number of other studies have been published on the efficacy of Permacol, all suggesting similar healing rates [ 20 , 21 , 22 , 23 , 24 ]. Nonetheless, outcome data in complex anal fistulas are scarce, and the available evidence is based on studies which are limited in sample size (i.e.…”

Simple fistula-in-ano: is it all simple? A systematic review

“…Sphincter-sparing techniques were adopted to treat 602 patients (weighted average age: 36.2 years; M:F ratio 4:1) with a simple AF (Table 2). Among those, glues/pastes (fibrin glue, Permacol® collagen paste, and cyanoacrylate glue) were the most frequently analyzed procedures with ten records [20,28,58,60,61,64,65,68,71,74]. LIFT and the laser closure of fistula tracts were reported in five [54,62,66,69,76] and four studies [59,67,70,72], respectively.…”