Permanently Charged Cationic Lipids—Evolution from Excipients to Therapeutic Lipids
Pushpa Ragini S,
Rajkumar Banerjee,
Calum J. Drummond
et al.
Abstract:Cationic lipids are crucial in medical and biotechnological applications including cellular transfection and gene delivery. Ionizable cationic lipids are critical components of the mRNA‐based COVID vaccines while permanently charged cationic lipids have shown promise in cancer treatment. Despite significant research progress over the past few decades in designing improved, biocompatible cationic lipids, their transfection efficiency remains lower than that of viral vectors. Cationic lipids with additional func… Show more
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