Permeation of Ionic Liquids through the skin

Abstract

233 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Permeation of Ionic Liquids through the skin Permeação de Líquidos Iónicos através da pele AbstractAlternative forms of drug delivery such as delivery through the skin, have been developed to explore other routes. However, the incorporation of poorly soluble or partially insoluble drugs into these delivery systems represents a major problem. Ionic liquids (ILs) may be incorporated in aqueous, oily or hydroalcoholic solutions and thus, may be used as excipients in drug delivery systems to increase/improve the topical and transdermal drug delivery. However, it is fundamental to consider the cytotoxicity of these salts and it is also crucial to evaluate if these compounds permeate through the skin.

TransfersomILs: From Ionic Liquids to a New Class of Nanovesicular Systems

“…For the preparation of transfersomes, methanol was from Carlo Erba Reagenti SpA (Rodano, Italy), chloroform from Sigma–Aldrich Chemie Gmbh (Munich, Germany), Tween ® 80 from Sigma–Aldrich (Saint Louis, MO, USA), and soy phosphatidylcholine from Alfa Aesar (Kandel, Germany). For the release study, phosphate-buffered saline (PBS, pH 7.4) was prepared as previously described [ 54 ].…”