Peroxiredoxin 1 – an antioxidant enzyme in cancer

Abstract

Peroxiredoxins (PRDXs), a ubiquitous family of redox‐regulating proteins, are reported of potential to eliminate various reactive oxygen species (ROS). As a major member of the antioxidant enzymes, PRDX1 can become easily over‐oxidized on its catalytically active cysteine induced by a variety of stimuli in vitro and in vivo. In nucleus, oligomeric PRDX1 directly associates with p53 or transcription factors such as c‐Myc, NF‐κB and AR, and thus affects their bioactivities upon gene regulation, which in turn induces or suppresses cell death. Additionally, PRDX1 in cytoplasm has anti‐apoptotic potential through direct or indirect interactions with several ROS‐dependent (redox regulation) effectors, including ASK1, p66Shc, GSTpi/JNK and c‐Abl kinase. PRDX1 is proven to be a versatile molecule regulating cell growth, differentiation and apoptosis. Recent studies have found that PRDX1 and/or PRDX1‐regulated ROS‐dependent signalling pathways play an important role in the progression and metastasis of human tumours, particularly in breast, oesophageal and lung cancers. In this paper, we review the structure, effector functions of PRDX1, its role in cancer and the pivotal role of ROS in anticancer treatment.

Peroxiredoxin 1 as an inflammatory marker in diarrhea‐predominant and postinfectious irritable bowel syndrome

“…17,[32][33][34] Continuous inflammatory responses in intestinal tissues are considered as the prominent pathological features of IBS, especially IBS-D and PI-IBS. 16,33,[35][36][37] PRDX1 is associated with some tumors [21][22][23]38 and especially associated with colorectal cancer caused by chronic inflammation. 39,40 However, few studies have examined the relationship between PRDX1 and intestinal inflammation.…”

“…In all IBS patients, the serum PRDX1 (r = .335, P < .001) and TNF-α 16,33,[35][36][37] PRDX1 is associated with some tumors [21][22][23]38 and especially associated with colorectal cancer caused by chronic inflammation. 39,40 However, few studies have examined the relationship between PRDX1 and intestinal inflammation.…”

“…For example, T lymphocytes, B lymphocytes, mast cells, and cytokine concentrations are altered in the local colonic mucosa or systemic circulation of patients with IBS relative to healthy controls. In addition to being associated with tumors, [21][22][23] PRDX1 is crucial in inflammatory responses. 15,16 Intestinal mucosal biopsy specimens from patients with PI-IBS and diarrhea-predominant IBS (IBS-D) show an increased number of immune cells, such as mast cells and lymphocytes.…”

“…[17][18][19][20] Peroxiredoxin 1 (PRDX1) belongs to the peroxide oxidoreductase protein family that plays a key role in fighting against reactive oxygen species and antioxidants. In addition to being associated with tumors, [21][22][23] PRDX1 is crucial in inflammatory responses. 24,25 PRDX1 expression is up-regulated in active ulcerative colitis (UC) specimens, and it increases with the rise in the inflammation level in UC regenerative mucosal crypt epithelial cells.…”

Exploring the key communicator role of exosomes in cancer microenvironment through proteomics

“…PRDX1 is an antioxidant enzyme, but its role in breast cancer is controversial. It is, however, clearly overexpressed in breast cancer tissue relative to normal tissue [70]. Recently, Bajor et al demonstrated that PRDX1 is involved in reducing exogenous oxidative stress and induces cell growth in breast cancer [71].…”