Peroxisomal Dysfunction Contributes to White Matter Injury Following Subarachnoid Hemorrhage in Rats via Thioredoxin-Interacting Protein-Dependent Manner

Xu, Weilin; Yan, Jun; Chen, Shuda; Ocak, Umut; Shao, Anwen; Zhang, Jianmin

doi:10.3389/fcell.2020.576482

Cited by 7 publications

(10 citation statements)

References 15 publications

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“…Furthermore, the white matter injury occurring at the early stage of SAH has not been addressed well so far. Recently, the damage caused by the SAH peroxisome in mouse models was found to escalate white matter injury to SAH, and was partially mediated by TXNIP and glycerone-phosphate acyl-transferase pathways [ 107 ].…”

Section: The Role Of Txnip In Diseasesmentioning

confidence: 99%

Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook

Qayyum

Haseeb

Kim

et al. 2021

IJMS

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Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is pivotal for the pathophysiology of some diseases. TXNIP increases reactive oxygen species production and oxidative stress and thereby contributes to apoptosis. Recent studies indicate an evolving role of TXNIP in the pathogenesis of complex diseases such as metabolic disorders, neurological disorders, and inflammatory illnesses. In addition, TXNIP has gained significant attention due to its wide range of functions in energy metabolism, insulin sensitivity, improved insulin secretion, and also in the regulation of glucose and tumor suppressor activities in various cancers. This review aims to highlight the roles of TXNIP in the field of diabetology, neurodegenerative diseases, and inflammation. TXNIP is found to be a promising novel therapeutic target in the current review, not only in the aforementioned diseases but also in prolonged microvascular and macrovascular diseases. Therefore, TXNIP inhibitors hold promise for preventing the growing incidence of complications in relevant diseases.

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Section: The Role Of Txnip In Diseasesmentioning

confidence: 99%

Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook

Qayyum

Haseeb

Kim

et al. 2021

IJMS

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“…TNFα, IL-1β, IL-6 and other molecules can directly affect the structure and function of the myelin sheath (Simard et al, 2012;Egashira et al, 2015;Xu et al, 2020). Moreover, ROS are involved in the TXNIP and GNPAT signaling pathways (Xu et al, 2020).…”

Section: Involved Brain Cellsmentioning

confidence: 99%

“…The downregulation of par1 expression with par1 siRNA can promote myelin regeneration after SAH (6). Recent studies have also found that after SAH, the administration of catalase CRISPR (clustered regularly interspaced short palindromic repeats) to rats can also prominently increase the expression of myelin basic protein (MBP), while also reducing APP, IL-6 and TNF α and subsequently cricially alleviate the neurological deficit (Xu et al, 2020). Generally, to treat myelin sheath injury after SAH, previous researchers have conducted many informative explorations from different aspects and obtained many important achievements, which have provided experimental conclusions and research experience for future precise treatments.…”

Section: Treatment Strategy For Myelin Sheath Injury Caused By Sahmentioning

confidence: 99%

Myelin sheath injury and repairment after subarachnoid hemorrhage

Chen

Guo

et al. 2023

Front. Pharmacol.

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Subarachnoid hemorrhage (SAH) can lead to damage to the myelin sheath in white matter. Through classification and analysis of relevant research results, the discussion in this paper provides a deeper understanding of the spatiotemporal change characteristics, pathophysiological mechanisms and treatment strategies of myelin sheath injury after SAH. The research progress for this condition was also systematically reviewed and compared related to myelin sheath in other fields. Serious deficiencies were identified in the research on myelin sheath injury and treatment after SAH. It is necessary to focus on the overall situation and actively explore different treatment methods based on the spatiotemporal changes in the characteristics of the myelin sheath, as well as the initiation, intersection and common action point of the pathophysiological mechanism, to finally achieve accurate treatment. We hope that this article can help researchers in this field to further clarify the challenges and opportunities in the current research on myelin sheath injury and treatment after SAH.

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“…supply during the myelination process, which requires a high oxygen consumption. Xu and colleagues recently reported that perioxisomal dysfunction exacerbated white matter injury after SAH, at least partly through thioredoxin-interacting protein and glycerone phosphate acyl transferase signals (84).…”

Section: Repair Factors Of White Matter After Sah Oligodendrocyte Precursor Cellsmentioning

confidence: 99%

Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage

Gao

Zhou

et al. 2021

Front. Neurol.

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Aneurysmal subarachnoid hemorrhage (SAH) is one of the special stroke subtypes with high mortality and mobility. Although the mortality of SAH has decreased by 50% over the past two decades due to advances in neurosurgery and management of neurocritical care, more than 70% of survivors suffer from varying degrees of neurological deficits and cognitive impairments, leaving a heavy burden on individuals, families, and the society. Recent studies have shown that white matter is vulnerable to SAH, and white matter injuries may be one of the causes of long-term neurological deficits caused by SAH. Attention has recently focused on the pivotal role of white matter injury in the pathophysiological processes after SAH, mainly related to mechanical damage caused by increased intracerebral pressure and the metabolic damage induced by blood degradation and hypoxia. In the present review, we sought to summarize the pathophysiology processes and mechanisms of white matter injury after SAH, with a view to providing new strategies for the prevention and treatment of long-term cognitive dysfunction after SAH.

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Peroxisomal Dysfunction Contributes to White Matter Injury Following Subarachnoid Hemorrhage in Rats via Thioredoxin-Interacting Protein-Dependent Manner

Cited by 7 publications

References 15 publications

Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook

Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook

Myelin sheath injury and repairment after subarachnoid hemorrhage

Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage

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