Peroxisomal Dysfunction in Neurological Diseases and Brain Aging

Uzor, Ndidi-Ese; McCullough, Louise D.; Tsvetkov, Andrey S.

doi:10.3389/fncel.2020.00044

Cited by 34 publications

(27 citation statements)

References 148 publications

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“…Conversely, peroxisomal dysfunction are linked to peroxisome biogenesis disorders. However, the effect of altered pexophagy in neurodegenerative diseases is poorly understood [ 150 ].…”

Section: Selective Autophagy and Its Relevance To Neurodegenerativmentioning

confidence: 99%

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Jiménez-Moreno

Lane

2020

Oxidative Medicine and Cellular Longevity

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated primarily from endogenous biochemical reactions in mitochondria, endoplasmic reticulum (ER), and peroxisomes. Typically, ROS/RNS correlate with oxidative damage and cell death; however, free radicals are also crucial for normal cellular functions, including supporting neuronal homeostasis. ROS/RNS levels influence and are influenced by antioxidant systems, including the catabolic autophagy pathways. Autophagy is an intracellular lysosomal degradation process by which invasive, damaged, or redundant cytoplasmic components, including microorganisms and defunct organelles, are removed to maintain cellular homeostasis. This process is particularly important in neurons that are required to cope with prolonged and sustained operational stress. Consequently, autophagy is a primary line of protection against neurodegenerative diseases. Parkinson’s is caused by the loss of midbrain dopaminergic neurons (mDANs), resulting in progressive disruption of the nigrostriatal pathway, leading to motor, behavioural, and cognitive impairments. Mitochondrial dysfunction, with associated increases in oxidative stress, and declining proteostasis control, are key contributors during mDAN demise in Parkinson’s. In this review, we analyse the crosstalk between autophagy and redoxtasis, including the molecular mechanisms involved and the detrimental effect of an imbalance in the pathogenesis of Parkinson’s.

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“…Conversely, peroxisomal dysfunction are linked to peroxisome biogenesis disorders. However, the effect of altered pexophagy in neurodegenerative diseases is poorly understood [ 150 ].…”

Section: Selective Autophagy and Its Relevance To Neurodegenerativmentioning

confidence: 99%

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Jiménez-Moreno

Lane

2020

Oxidative Medicine and Cellular Longevity

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“…Peroxisomes are evenly distributed in most cells; however, they are largely unknown for muscle cells. On the other hand, peroxisomes are critical for the nervous system as peroxisome dysfunction is associated with several neurological diseases (102). In mouse neurons, peroxisomes are mostly localized within the perinuclear region, but are rarely described in the axons and dendrites (Figure 3) (103).…”

Section: Er and Peroxisome Positioningmentioning

confidence: 99%

Organelle Positioning in Neurons and Skeletal Muscle Cells

2021

GMJ

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Organelles are dynamic compartments, whose spatial positions are tightly regulated for cellular functions. An increasing number of studies have shown dysregulations in organelle positions, especially in muscular and neurological diseases, therefore understanding the basic mechanisms of organelle positioning could help to develop new therapeutic strategies. In this review, we focused on the mechanisms of organelle positioning in two specialized cells, muscle and nerve, as well as the contribution of mispositioning to disease pathomechanisms.

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“…The integrity and stability of peroxisomes are important for the maintenance of normal mitochondrial function. Peroxisome dysfunction seriously affects mitochondrial metabolism, morphological stability, and biosynthesis, which directly or indirectly lead to rare genetic diseases, such as X-linked adrenoleukodystrophy (X-ALD), acatalasemia, and Zellweger syndrome, and age-related disorders such as PD (Muntau et al, 2000;Pascual-Ahuir et al, 2017;Uzor et al, 2020).…”

Section: Mitochondria Peroxisomes and Pdmentioning

confidence: 99%

“…Peroxisomes have shown interdependency with mitochondria, and experiments have been conducted to investigate possible connections between peroxisomes and PD (Lazarou et al, 2012;Uzor et al, 2020). Lazarou et al reported PD-related PINK1 and parkin ectopic localization to peroxisomes where they initiated pexophagy (Lazarou et al, 2012).…”

Section: Peroxisomes and Mitochondria Relationship With Pdmentioning

confidence: 99%

“…Recently, mounting evidence has indicated the interaction between peroxisomes and mitochondria. Both organelles play important roles in lipid β-oxidation metabolism, and both play a redox scavenging role to maintain cellular reactive oxygen species (ROS) homeostasis (Uzor et al, 2020). Interdependence between the two organelles has been noted, as dysfunction in one leads to dysfunction in the other.…”

Section: Introductionmentioning

confidence: 99%

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When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease

Lin

et al. 2020

Front. Cell Dev. Biol.

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Parkinson's disease (PD) is a complex neurodegenerative disease with pathological hallmarks including progressive neuronal loss from the substantia nigra pars compacta and α-synuclein intraneuronal inclusions, known as Lewy bodies. Although the etiology of PD remains elusive, mitochondrial damage has been established to take center stage in the pathogenesis of PD. Mitochondria are critical to cellular energy production, metabolism, homeostasis, and stress responses; the association with PD emphasizes the importance of maintenance of mitochondrial network integrity. To accomplish the pleiotropic functions, mitochondria are dynamic not only within their own network but also in orchestrated coordination with other organelles in the cellular community. Through physical contact sites, signal transduction, and vesicle transport, mitochondria and intracellular organelles achieve the goals of calcium homeostasis, redox homeostasis, protein homeostasis, autophagy, and apoptosis. Herein, we review the finely tuned interactions between mitochondria and surrounding intracellular organelles, with focus on the nucleus, endoplasmic reticulum, Golgi apparatus, peroxisomes, and lysosomes. Participants that may contribute to the pathogenic mechanisms of PD will be highlighted in this review.

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Peroxisomal Dysfunction in Neurological Diseases and Brain Aging

Cited by 34 publications

References 148 publications

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Organelle Positioning in Neurons and Skeletal Muscle Cells

When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease

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