Peroxisome Proliferator- Activated Receptor-gamma and Nuclear Factor-kappa B in Obese Breast Cancer Patients: Correlation with Omega-3 polyunsaturated Fatty Acids with Adjuvant Chemotherapy

Abstract

Background: PPAR-γ has been reported to affect cell proliferation/differentiation pathways in various malignancies. PPAR-γ negatively regulates NF-κB gene which is important in breast cancer progression. Objective: The present study was designed to evaluate the relationship between PPAR-γ and NF-κB and the clinicopathological parameters of breast cancer women. The possible effects of adjuvant omega-3 fatty acid treatment with chemotherapy was also studied. Methods: 40 obese breast cancer patients was subdivided into two groups(20 each),chemo group received chemotherapy alone and omega group received 2 gm n-3 daily wih chemotherapy and control group included 20 obese women. Serum PPAR-γ and NF-κB levels were conducted for all the studied groups. Results: PPAR-γ was significantly lower than control .The level was decreased with increased positivity of ER, PR and increased with Her-2/neu in pre-and postmenopausal breast cancer patients. NF-κB significantly higher than controls and decreased with the increased positivity of ER, PR and Her-2/neu in pre-and postmenopausal breast cancer patients. Omega-3 FAs treatment with chemotherapy significantly enhances the level of PPAR-γ and decreases NF-κB level. Conclusion:The using of omega-3 PUFA as adjuvant treatment may increase sensitivity of cancer cells for chemotherapy by targeting PPAR-γ /NF-κB signaling pathway through correction of their derangements.

Multifunctional Composite Based on Cotton Fabric and Starch‐Copper Ferrite Hydrogel Prepared through Facile Room Temperature Preparation Approach

“…However, in several cases antibacterial efficiency of hydrogel was not satisfactory and also after release of the antibacterial agents, the composite expressed no antibacterial activity. [ 32,33,42 ] Despite the above‐mentioned deficiencies of common hydrogels, the nanocomposite exhibited 100% antibacterial activity against both Gram positive and Gram negative model bacteria ( Table 4 ). The antibacterial activity of nanocomposite was superior to other cotton‐nanometals.…”

“…Textile‐hydrogel composites have been extensively used in biomedical applications for absorption of wound exudates, transdermal therapy, controlled drug release, and retention of antibacterial agents and curatives. [ 32–37 ] They are used to absorb contaminates in environmental applications. [ 38–40 ] They can be tailored to switch between water or oil separator in different conditions.…”