Peroxisome Proliferator-Activated Receptor γ–Mediated Up-regulation of Syndecan-1 by n-3 Fatty Acids Promotes Apoptosis of Human Breast Cancer Cells

Sun, Haiguo; Berquin, Isabelle M.; Owens, Rick T.; O’Flaherty, Joseph T.; Edwards, Iris J.

doi:10.1158/0008-5472.can-07-2305

Cited by 106 publications

(114 citation statements)

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“…However, the ratio of O-6FAs to O-3FAs may be more meaningful than the absolute amount of O-3FAs [56][57][58]. A high dietary ratio of O-6FAs/O-3FAs may raise the risk of higher grade CaP and overall CaP incidence [55,59,60].…”

Section: Carcinoma Of Prostate (Cap)mentioning

confidence: 99%

Influence of polyunsaturated fatty acids on urologic inflammation

et al. 2015

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Section: Carcinoma Of Prostate (Cap)mentioning

confidence: 99%

Influence of polyunsaturated fatty acids on urologic inflammation

et al. 2015

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“…Moreover, it has been shown [131] that DHA induced apoptosis in MCF-7 human breast cancer cells by the activation of PPARc and consequent up-regulation of syndecan-1 (SDC-1), the major proteoglycan produced by epithelial cells, strategically placed in the plasma membrane to regulate growth factor signaling and cell-cell and cell-matrix interactions. Worth noting, often the mechanisms hypothesized for the apoptotic effect of n-3 PUFAs in breast cancer cells [130,131] involve modifications of the plasma membrane environment, due to alterations of the molecular composition of lipid plasma membrane microenvironment (rafts), or to the increased expression of a plasma membrane molecule (SDC-1) playing a crucial role in the regulation of cell growth molecular signaling.…”

Section: Breast Cancer Cellsmentioning

confidence: 99%

Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer

et al. 2009

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It has recently become clear the role played by alterations in apoptosis during the development of several chronic diseases (i.e. inflammatory, neurodegenerative and neoplastic pathologies). For this reason, the research for possible therapeutic strategies involving the modulation of the apoptotic pathways has attracted considerable interest in the past few years. In particular, it has been shown that apoptosis may be induced or inhibited by a variety of nutritional compounds providing health benefits. The aim of this review is to examine the ability of different dietary polyunsaturated fatty acids (PUFAs) to induce apoptosis, especially in the cancer field. The molecular effects of different PUFAs found in dairy products, meat, fish, vegetable seeds and oils, and known to affect the incidence and progression of cancer and other chronic diseases, will be analyzed. To this aim, our effort will concentrate in critically reviewing the published works concerning the effects of: (a) the n-6 PUFAs gamma-linolenic acid, arachidonic acid, and conjugated linoleic acid; (b) the n-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid on the apoptotic process. We will also pay attention to the recent findings regarding the possible role of PUFAs as regulators of the endoplasmic reticulum stress-pathway of apoptosis.

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“…Studies have demonstrated that docosahexaenoic acid (DHA), a ω3-polyunsaturated fatty acid (ω3-PUFA), inhibits the accumulation of β-catenin protein and ultimately induces cancer cell growth and apoptosis in cholangiocarcinoma, hepatocellular carcinoma, lung, breast and colorectal cancer cells [10,11,12,13,14,15,16]. However, the relationship between ω3-PUFAs and Wnt/β-catenin pathway in human pancreatic cancer has not been elucidated yet.…”

Section: Introductionmentioning

confidence: 99%