Persicae Semen Promotes Bone Union in Rat Fractures by Stimulating Osteoblastogenesis through BMP-2 and Wnt Signaling

Jun, Jae‐Yun; Kim, Jae-Hyun; Kim, Min-Sun; Hong, Sooyeon; Kim, Myunghyun; Ryu, Gwang-hyun; Park, Jae Ho; Jung, Hyuk‐Sang; Sohn, Youngjoo

doi:10.3390/ijms24087388

Cited by 8 publications

(3 citation statements)

References 51 publications

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“…PS facilitates mineralization and up-regulates Runx2 via BMP-2 and Wnt signaling pathways. Consequently, this leads to the expression of various osteoblast genes, including Alp , bone gamma-carboxyglutamate protein ( Bglap ), and integrin binding sialoprotein ( Ibsp ) 131 . Research has demonstrated that PS promotes fracture recovery by enhancing osteoblast differentiation and bone formation.…”

Section: Osteoblast Signalingmentioning

confidence: 99%

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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

Zhu,

Chen,

Masson

et al. 2024

Cell Discov

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The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell signal transduction and transcriptional gene expression. Various essential cell signaling pathways, including Wnt, BMP, TGF-β, Hedgehog, PTH, FGF, Ephrin, Notch, Hippo, and Piezo1/2, play a critical role in facilitating osteoblast differentiation, bone formation, and bone homeostasis. Key transcriptional factors in this differentiation process include Runx2, Cbfβ, Runx1, Osterix, ATF4, SATB2, and TAZ/YAP. Furthermore, a diverse array of epigenetic factors also plays critical roles in osteoblast differentiation, bone formation, and homeostasis at the transcriptional level. This review provides an overview of the latest developments and current comprehension concerning the pathways of cell signaling, regulation of hormones, and transcriptional regulation of genes involved in the commitment and differentiation of osteoblast lineage, as well as in bone formation and maintenance of homeostasis. The paper also reviews epigenetic regulation of osteoblast differentiation via mechanisms, such as histone and DNA modifications. Additionally, we summarize the latest developments in osteoblast biology spurred by recent advancements in various modern technologies and bioinformatics. By synthesizing these insights into a comprehensive understanding of osteoblast differentiation, this review provides further clarification of the mechanisms underlying osteoblast lineage commitment, differentiation, and bone formation, and highlights potential new therapeutic applications for the treatment of bone diseases.

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Section: Osteoblast Signalingmentioning

confidence: 99%

“…Research has demonstrated that PS promotes fracture recovery by enhancing osteoblast differentiation and bone formation. Consequently, it could serve as a potential treatment option for patients with fractures 131 .…”

Section: Osteoblast Signalingmentioning

confidence: 99%

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

Zhu,

Chen,

Masson

et al. 2024

Cell Discov

View full text Add to dashboard Cite

show abstract

“…Activation of BMP-2 phosphorylates Smad and facilitates its translocation to the nucleus, activating p38 signaling. This, in turn, upregulates the expression of Runt-associated transcription factor 2 (RUNX2), which further promotes the process of fracture healing ( 88 ).…”

Section: The Role Of Primary Cilia In Bone Metabolismmentioning

confidence: 99%

Recent advances in primary cilia in bone metabolism

Lian,

Li,

et al. 2023

Front. Endocrinol.

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Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which is propelled by kinesin and dynein motors, plays a crucial role in the formation and functionality of cilia. Abnormalities in the cilia or ciliary transport system often cause a range of clinical conditions collectively known as ciliopathies, which include polydactyly, short ribs, scoliosis, thoracic stenosis and many abnormalities in the bones and cartilage. In this review, we summarize recent findings on the role of primary cilia and ciliary transport systems in bone development, we describe the role of cilia in bone formation, cartilage development and bone resorption, and we summarize advances in the study of primary cilia in fracture healing. In addition, the recent discovery of crosstalk between integrins and primary cilia provides new insights into how primary cilia affect bone.

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Traditional Use, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Persicae Semen: A Review

Liu,

Wu,

Zhang

et al. 2024

Chin. J. Integr. Med.

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Persicae Semen Promotes Bone Union in Rat Fractures by Stimulating Osteoblastogenesis through BMP-2 and Wnt Signaling

Cited by 8 publications

References 51 publications

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

Recent advances in primary cilia in bone metabolism

Traditional Use, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Persicae Semen: A Review

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