Persistent acantholytic dermatosis. A variant of transient acantholytic dermatosis (Grover disease)

Simón, Rogelio

doi:10.1001/archderm.112.10.1429

Cited by 41 publications

(33 citation statements)

References 3 publications

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“…The latter is probably a variant of the former (Chalet et al 1977). Histopathologically the present case shows a pemphigus vulgaris-like pattern (Feinstein et al 1971, Simon et al 1976, Chalet et al 1977 with some spongiotie changes (Simon et al 1976, Chalet et al 1977) of transient acantholytic dermatosis. Also, ultrastructurally this case mimics pemphigus vulgaris, as mentioned previously.…”

Section: Discussionsupporting

confidence: 46%

“…Acantholysis may be observed in several skin or mucous membrane diseases, such as pemphigus, Darier disease, benign chronic familial pemphigus (Hailey-Hailey disease), transient acantholytic dermatosis (Grover 1970, Feinstein et al 1971, Simon et al 1976, Waisman et al 1976, Chalet et al 1977, benign papular acantholytic dermatosis (Heaphy et al 1976), focal acantholytic dyskeratosis (Ackerman 1972), viral diseases and tumors.…”

Section: Discussionmentioning

confidence: 99%

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Transient Acantholytic Dermatosis with Involvement of Oral Mucosa

Kanzaki

Hashimoto

1978

J Cutan Pathol

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Histologic, immunologic and electron microscopic studies were performed in a patient with transient acantholytic dermatosis which involved oral mucosa. Hitologic and electron microscopic findings were almost identical in both cutaneous and mucous membrane lesions, and these were similar to pemphigus vulgaris; suprabasilar separation with acantholytic cells. Desmosome-desmosome complexes were separated without disruption of cell membranes and cytoplasmic structures were well-preserved without dyskeratosis. Lamina lucida, however, was often separated in mucous membrane lesions, in contrast to the normal lamina lucida in cutaneous lesions of such cases or in pemphigus vulgaris. Direct and indirect immunofluorescence studies for pemphigus were repeatedly negative. This study shows that transient acantholytic dermatosis may involve mucous membrane and may resemble pemphigus vulgaris histologically and ultrastructurally except for the widened lamina lucida of the mucous membrane.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Transient Acantholytic Dermatosis with Involvement of Oral Mucosa

Kanzaki

Hashimoto

1978

J Cutan Pathol

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“…Acantholytic changes may be seen in numerous and heterogeneous clinical conditions: (i) genodermatoses (Hailey-Hailey disease, Darier disease); (ii) infections; (iii) pemphigus; (iv) several malignant or premalignant conditions (acantholytic type of solar keratosis, in which one observes immediately above the atypical cells composing the basal cell layer clefts or lacunae similar to those seen in Darier disease [8]or in Paget disease [9]); (v) Grover disease [10, 11, 12]. …”

Section: Discussionmentioning

confidence: 99%

In vivo Enalapril-Induced Acantholysis

Schiavo

Guerrera²,

Cozzani³

et al. 1999

Dermatology

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Enalapril is a widely used antihypertensive drug with a very powerful in vitro acantholytic effect. It has been known to potentially induce pemphigus in genetically predisposed subjects. The action mechanism is complex and still only partially understood. We describe the case of a 66-year-old man, affected with intermediary basal cell carcinoma, in whom the histological examination showed suprabasal acantholytic clefts in the perilesional epidermis. Surprisingly a second biopsy taken from the apparently healthy skin of his back confirmed the presence of acantholytic changes. Clinical signs of pemphigus were absent. The patient’s history did not reveal any relevant data but a mild arterial hypertension that had been treated for 1 year with 10 mg enalapril. Taking into account the patient’s history (enalapril long-term administration), the absence of any bullous or erosive lesions and the histological findings, a diagnosis was made of in vivo enalapril-induced acantholysis.

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“…They used the title of benign papular acantholytic dermatosis and noted that the lesions were initiated or exacerbated by stinlight in five of seven cases. In one subsequent patient the eruption lasted over 5 years (Simon, Bloom & Ackerman, 1976) and histologically showed foci of spongiosis in addition to acantholysis, dyskeratosis and suprabasal clefting. Fawcett & Miller (1983) have collected a series of cases of persistent acantholytic dermatosis seen at London hospitals during the period t969 to 1982.…”

Section: Commentmentioning

confidence: 94%