Persistent Arthralgia Associated with Chikungunya Virus: A Study of 88 Adult Patients on Reunion Island

Borgherini, Gianandréa; Poubeau, P.; Jossaume, Annie; Gouix, A.; Cotte, L.; Michault, Alain; Arvin-Berod, C.; Paganin, F.

doi:10.1086/590003

Cited by 373 publications

(343 citation statements)

References 24 publications

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“…All patients had high fever, rash, and arthralgia (Materials and Methods, Supplemental Tables I, II). It was noted that all the 14 CHIKV-infected patients presented marked leucopenia during the acute phase of the infection in agreement with previous studies (23,30). As a result of this phenomenon, reduced amounts of viable PBMCs were obtained and processed from all the patients.…”

Section: Detection Of Chikv In Monocytes During Acute Viremic Phase Osupporting

confidence: 88%

“…The events taking place during the acute blood phase of CHIKV infections have not been clearly defined. Although the viremic period in humans is relatively short (23,24), the plasmatic levels of virus can go up to very high levels (3.3 3 10 9 viral copies/ml) in CHIKV-infected patients (24). Such high levels of circulating virus suggest that blood leukocytes could be infected by CHIKV and involved in viral production.…”

Section: Hikungunya Virus (Chikv) Is the Causative Agent Formentioning

confidence: 99%

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Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

Her

Malleret

Chan

et al. 2010

The Journal of Immunology

253

254

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Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. To date, interactions between the immune system and the different stages of the virus life cycle remain poorly defined. We demonstrated for the first time that CHIKV Ags could be detected in vivo in the monocytes of acutely infected patients. Using in vitro experimental systems, whole blood and purified monocytes, we confirmed that monocytes could be infected and virus growth could be sustained. CHIKV interactions with monocytes, and with other blood leukocytes, induced a robust and rapid innate immune response with the production of specific chemokines and cytokines. In particular, high levels of IFN-α were produced rapidly after CHIKV incubation with monocytes. The identification of monocytes during the early phase of CHIKV infection in vivo is significant as infected monocyte/macrophage cells have been detected in the synovial tissues of chronically CHIKV-infected patients, and these cells may behave as the vehicles for virus dissemination. This may explain the persistence of joint symptoms despite the short duration of viremia. Our results provide a better understanding on the basic mechanisms of infection and early antiviral immune responses and will help in the development of future effective control strategies.

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Section: Detection Of Chikv In Monocytes During Acute Viremic Phase Osupporting

confidence: 88%

Section: Hikungunya Virus (Chikv) Is the Causative Agent Formentioning

confidence: 99%

Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

Her

Malleret

Chan

et al. 2010

The Journal of Immunology

253

254

View full text Add to dashboard Cite

show abstract

“…Long-term sequelae, especially arthralgia, have been reported in uncontrolled studies. 20 However, the only study to date using matched controls found that CHIKVinfected patients had only slightly reduced physical scores for quality of life, with no impact on medical care received or mental scores. 21 In support of this, we found no residual physical dependence or depression in our sample.…”

Section: Discussionmentioning

confidence: 97%

Seroprevalence Survey of Chikungunya Virus in Bagan Panchor, Malaysia

Said¹,

Lai²,

Chan³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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In 2006, an outbreak of Chikungunya virus (CHIKV) of the Asian genotype affected over 200 people in Bagan Panchor village in Malaysia. One year later, a post-outbreak survey was performed to determine attack rate, asymptomatic rate, and post-infection sequelae. Findings were compared with recent CHIKV outbreaks of the Central/East African genotype. A total of 180 residents were interviewed for acute symptoms and post-infection physical quality of life and depressive symptoms. Sera from 72 residents were tested for CHIKV neutralizing antibodies. The estimated attack rate was 55.6%, and 17.5% of infected residents were asymptomatic. Arthralgia was reported up to 3 months after infection, but there were no reports of long-term functional dependence or depression. Symptomatic and seropositive residents were significantly more likely to live in the area with the most dense housing and commercial activities. CHIKV had a high attack rate and considerable clinical impact during the Bagan Panchor outbreak.

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“…Complications of Dengue infections such as encephalitis, hemorrhagic symptoms, severe hematological changes and fatal outcomes are rarely associated with Chikungunya virus. Chikungunya infection however results in prolonged and slow recovery from the polyarthralgias, often persisting for months (Chattopadhyay et al, 2016;Borgherini et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Diagnosis of Chikungunya by a Rapid Immunochromatographic Method in a Tertiary Care Setting

Rajgopal¹

2017

Int.J.Curr.Microbiol.App.Sci

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Persistent Arthralgia Associated with Chikungunya Virus: A Study of 88 Adult Patients on Reunion Island

Cited by 373 publications

References 24 publications

Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

Seroprevalence Survey of Chikungunya Virus in Bagan Panchor, Malaysia

Diagnosis of Chikungunya by a Rapid Immunochromatographic Method in a Tertiary Care Setting

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