Persistent asthma after acute inhalation of organophosphate insecticide

Deschamps, D.; Questel, Frank; Fj, Baud; Gervais, Pierre; Dally, S

doi:10.1016/s0140-6736(94)90498-7

Cited by 42 publications

(24 citation statements)

References 5 publications

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“…This observation also lacks consistency with previous studies, as obstructive abnormalities of the lungs have been reported following chronic exposure Klucinski et al, 1997) and acute exposure (Deschamps et al, 1994) to these compounds. Therefore, it seems that this finding is very likely a chance observation.…”

Section: Discussioncontrasting

confidence: 53%

Low Level of Exposure to Pesticides Leads to Lung Dysfunction in Occupationally Exposed Subjects

Hernández

Casado²,

Pena

et al. 2008

Inhalation Toxicology

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Pesticides may contribute to adverse respiratory health effects among farmers and have been considered one causal factor for the rise in asthma prevalence. This cross-sectional study was conducted to evaluate potential respiratory function abnormalities following long-term pesticide exposure by means of a complete pulmonary function testing, including spirometry, lung volumes, and diffusing capacity for carbon monoxide. The study population was comprised by workers from a prominent intensive agriculture area of southern Spain that relied on pesticides for the control of plagues. Eighty-nine pesticide sprayers of plastic greenhouse farming and a control group of 25 nonspraying control farmers from the same area were interviewed by a general practitioner asking about sociodemographic factors, occupational exposure, and clinical symptoms by using a structured questionnaire. Multiple regression analyses showed a relationship of short-term exposure to pesticides (as indicated by a drop in serum cholinesterase >25% of baseline levels) with reduced forced expired volume in 1 s, and of long-term exposure (as indicated by a cumulative pesticide exposure index) with reduced forced expiratory flow rate. Exposure to bipyridilium-class herbicides was a determinant of a fall in the diffusing capacity of the lungs, and neonicotinoid insecticides showed a relationship with lower pulmonary volumes (total lung capacity, residual volume, and functional residual capacity), suggestive of restrictive lung disease, and with an increased risk of reporting irritative symptoms.

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Section: Discussioncontrasting

confidence: 53%

Low Level of Exposure to Pesticides Leads to Lung Dysfunction in Occupationally Exposed Subjects

Hernández

Casado²,

Pena

et al. 2008

Inhalation Toxicology

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“…Approximately 4% of villagers were exposed regularly to insecticides containing mostly organophosphate and pyrethrin; these chemicals have been shown to give rise to asthma [17][18][19][20]. A study of 1,939 farmers in Saskatchewan, Canada, found an increased risk of asthma associated Data are presented as odds ratio (95% confidence interval).…”

Section: Discussionmentioning

confidence: 99%

Occupational and environmental risk factors for respiratory symptoms in rural Beijing, China

Da²,

He³

et al. 2002

Eur Respir J

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The aim of the present study was to determine the effects of occupational and environmental exposure on respiratory symptoms in adults in rural Beijing, China.Thirty randomly selected villages in the counties of Shunyi and Tongxian, 50 km north and east, respectively, of the city of Beijing, China, participated in this study. Village doctors interviewed all residents aged ≥15 yrs and completed the International Union Against Tuberculosis and Lung Disease Questionnaire on Bronchial Symptoms translated into Chinese with added questions on smoking and occupational and environmental exposure.Of the eligible population, 22,528 adults (98%) took part. The prevalence of all respiratory symptoms,i.e.asthma-like symptoms, asthma attacks in the last 12 months, chronic cough and chronic phlegm, was low. Significant determinants for respiratory symptoms were age, sex, smoking and county of residence. A dose-dependent relationship was found between cumulative cigarette consumption and prevalence of respiratory symptoms. After adjusting for these variables, exposure to insecticides and fertilisers significantly increased the risk of most of the respiratory symptoms, whereas exposure to indoor air pollution from domestic fuels did not.Exposure to chemicals such as insecticides and fertilisers contributed independently to the risk of respiratory symptoms in rural Beijing, China.

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“…In a cross-sectional study of farmers in Saskatchewan, the investigators found that the prevalence of asthma was highly correlated with use of carbamate insecticides [Senthilselvan et al, 1992]. Several case reports have been published linking insecticide and fungicide exposure to asthma [Royce et al, 1993;Deschamps et al, 1994]. Application of pesticide to livestock is typically done by hand, pouring the chemical over the animal.…”

Section: Discussionmentioning

confidence: 99%

“…In one cross-sectional study conducted in Canada, the use of carbamate insecticides was signi®cantly related to the prevalence of asthma in a population of male farmers [Senthilselvan et al, 1992]. A few case reports have documented asthma symptoms after exposure to organophosphate insecticides [Bryant, 1985;Deschamps et al, 1994] and fungicides [Honda et al, 1992;Royce et al, 1993].…”

Section: Introductionmentioning

confidence: 99%

Respiratory symptoms: Associations with pesticides, silos, and animal confinement in the Iowa Farm Family Health and Hazard Surveillance Project

et al. 2000

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Background Farmers are at risk for airways diseases resulting from exposures which include organic agents and chemicals on the farm. Few data on airways disease and farm exposures are available from population‐based studies. The Iowa Farm Family Health and Hazard Surveillance Project provided the opportunity to assess associations between symptoms of airway disease and several farm exposures, including pesticides, grain dust, animal confinement, and exposures from silos, in a population‐based study. Methods A stratified two‐stage cluster sample was used to provide a representative farmer sample from the state. Participants provided questionnaire responses concerning demographic, respiratory symptoms, smoking, and exposure information. Associations between farm exposures and airways disease symptoms were assessed in the 385 farmer participants using χ2 analysis and logistic regression analysis adjusting for age and smoking. Results The most frequently reported respiratory symptoms were flu‐like symptoms in connection with dusty work (22%), dyspnea (21%), and phlegm (15%). Current smoking was uncommon (13%). Among farmers, applying pesticides to livestock was associated with significantly increased odds of phlegm (OR = 1.91, 95% CI 1.02–3.57), chest ever wheezy (OR = 3.92, 95% CI 1.76–8.72), and flu‐like symptoms (OR = 2.93, 95% CI 1.69–5.12) in models adjusting for age and smoking. Conventional vertical silos were significantly associated with increased odds of chest ever wheezy (OR = 2.75, 95% CI 1.23–6.12) and flu‐like symptoms (OR = 2.40, 95% CI 1.31–4.37). There were also significant associations between several respiratory symptoms and the presence of animal confinement facilities on the farm. Conclusions The association between insecticide application to livestock and symptoms of airways disease is a new finding that could lead to further study of specific airway responses and exposures associated with this practice. Results confirming associations between respiratory symptoms and conventional vertical silos may be important in future studies aimed at prevention and control of exposures in those farm buildings. Am. J. Ind. Med. 38:455–462, 2000. © 2000 Wiley‐Liss, Inc.

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Persistent asthma after acute inhalation of organophosphate insecticide

Cited by 42 publications

References 5 publications

Low Level of Exposure to Pesticides Leads to Lung Dysfunction in Occupationally Exposed Subjects

Low Level of Exposure to Pesticides Leads to Lung Dysfunction in Occupationally Exposed Subjects

Occupational and environmental risk factors for respiratory symptoms in rural Beijing, China

Respiratory symptoms: Associations with pesticides, silos, and animal confinement in the Iowa Farm Family Health and Hazard Surveillance Project

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