2020
DOI: 10.1186/s12888-020-2460-5
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Persistent depressive disorder across the adult lifespan: results from clinical and population-based surveys in Germany

Abstract: Background: Although the individual and economic disease burden of depression is particularly high for long-term symptoms, little is known of the lifetime course of chronic depression. Most evidence derives from clinical samples, and the diagnostic distinction between persistent depressive disorder (PDD) and non-chronic major depression (NCMDD) is still debated. Thus, we examined characteristics of PDD among clinical vs. non-clinical cases, and the associated disease burden at a population level. Methods: Data… Show more

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Cited by 27 publications
(22 citation statements)
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“…Findings suggest that about a third of all depressed patients develop a chronic form of depression (3,5,6). Compared to non-chronic forms of depression, PDD patients tend to have a significantly earlier onset and higher levels of treatment resistance (1,2,5).…”
Section: Introductionmentioning
confidence: 98%
See 1 more Smart Citation
“…Findings suggest that about a third of all depressed patients develop a chronic form of depression (3,5,6). Compared to non-chronic forms of depression, PDD patients tend to have a significantly earlier onset and higher levels of treatment resistance (1,2,5).…”
Section: Introductionmentioning
confidence: 98%
“…PDD is defined by a duration of depressive symptoms for a minimum of 2 years and ranging in severity from dysthymia to chronic major depression [according to DSM-5, ( 4 )]. Findings suggest that about a third of all depressed patients develop a chronic form of depression ( 3 , 5 , 6 ). Compared to non-chronic forms of depression, PDD patients tend to have a significantly earlier onset and higher levels of treatment resistance ( 1 , 2 , 5 ).…”
Section: Introductionmentioning
confidence: 99%
“…Depression is already known to follow distinct trajectories: The persistent depressive disorder must be distinguished from non-chronic major depression, which clearly differ in their course and therapeutic consequences [ 14 ]. However, little is known on symptom trajectories and associated factors of depressive symptoms following critical illness.…”
Section: Introductionmentioning
confidence: 99%
“…As compared to the episodic form of depression, Persistent Depressive Disorder (PDD) is associated with stronger impairment in life and higher social and economic costs ( 23 ). Although it has often been hypothesized that a chronic course of depression may be explained by dysfunctional interpersonal patterns, there is a lack of research supporting this assumption.…”
Section: Introductionmentioning
confidence: 99%