Persistent elevation of serum CA 19-9 with no evidence of malignant disease

Ventrucci, Maurizio; Pozzato, P.; Cipolla, Antonio; Uomo, Generoso

doi:10.1016/j.dld.2008.04.002

Cited by 64 publications

(44 citation statements)

References 36 publications

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“…As noted earlier, CA 19-9 serum levels may be elevated in a variety of nonpancreatic neoplastic conditions resulting in a high false positive rate (10-30%). Benign conditions associated with elevated serum CA 19-9 levels include ovarian cyst, heart failure, hashimoto's thyroiditis, rheumatoid arthritis and diverticulitis [16][17][18][19][69][70][71][72][73][74] (Table 6). Marked elevations in CA 19-9 serum levels have also been reported in numerous benign and malignant biliary conditions .8%) such as choledocholithiasis, gall bladder cancer and cholangiocarcinoma.…”

Section: Limitations Of Ca 19-9 Serum Levels As a Pancreatic Cancer Bmentioning

confidence: 99%

“…Marked elevations in CA 19-9 serum levels have also been reported in numerous benign and malignant biliary conditions .8%) such as choledocholithiasis, gall bladder cancer and cholangiocarcinoma. Finally, CA 19-9 serum levels alone cannot differentiate between benign, precursor lesions and malignant pancreatic conditions such as acute and chronic pancreatitis, intraductal pancreatic mucinous neoplasm (IPMN), pancreatic intra-epithelial neoplasia (PANIN) and pancreatic cancer as the former are also associated with elevated CA 19-9 serum levels in 10-50% of cases [69][70][71][72][73][74][75].…”

Section: Limitations Of Ca 19-9 Serum Levels As a Pancreatic Cancer Bmentioning

confidence: 99%

See 1 more Smart Citation

Serum CA 19-9 as a Biomarker for Pancreatic Cancer—A Comprehensive Review

Ballehaninna

Chamberlain

2011

Indian J Surg Oncol

213

161

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Section: Limitations Of Ca 19-9 Serum Levels As a Pancreatic Cancer Bmentioning

confidence: 99%

Section: Limitations Of Ca 19-9 Serum Levels As a Pancreatic Cancer Bmentioning

confidence: 99%

Serum CA 19-9 as a Biomarker for Pancreatic Cancer—A Comprehensive Review

Ballehaninna

Chamberlain

2011

Indian J Surg Oncol

213

161

View full text Add to dashboard Cite

show abstract

“…This case was of particular interest for the following reasons: first, the appearance of gastrointestinal symptoms, such as bloating, diarrhea and weight loss, due to the appearance of lactose intolerance [4]; second, the transient increase of CA 19-9 in celiac patients which was due to causes other than the presence of gastrointestinal cancer, which usually indicates in the general population [5], and third, capsule endoscopy was useful in detecting ileal mucosa abnormalities which disappear after going on a gluten-and cow milk-free diet.…”

Section: Discussionmentioning

confidence: 99%

Capsule Endoscopy Detection of Ileal Mucosa Alterations due to Cow Milk Malabsorption in a Celiac Patient

Pezzilli¹

2012

J Aller Ther

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We report a case of a 77-year-old man suffering from celiac disease admitted as an outpatient to our clinic for the persistence of bloating and diarrhea without macroscopic steatorrhea, weight loss or an increase in circulating carbohydrate antigen 19-9. An esophagogastroduodenoscopy showed H. pylori negative antral gastritis and atrophy of the duodenal mucosa and the results of a colonoscopy were normal. Abdominal contrast-enhanced computed tomography did not show any parenchymal alteration of the liver and pancreas. The patient underwent a capsule endoscopy and the examination showed the presence of villous atrophy with microerosions at the level of the medial jejunum, in the ileum, and some areas of lymphangiectasia. A repeated capsule endoscopy after starting a lactosefree diet showed the normalization of the jejunum-ileum villous atrophy. At present, the patient is in good general health and continues a gluten-and cow milk-free diet. We should be aware that celiac patients may have lactose intolerance that cause malabsorption; the transient increase of CA 19-9 in celiac patients may be due to causes other than the presence of gastrointestinal cancer; the capsule endoscopy is useful in detecting ileal mucosa abnormalities which disappear after going on gluten-and cow milk-free diet.

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“…CA 19-9 can increase in different benign conditions, including diverticular disease, as well (3,21).…”

Section: Afp and Ca 19-9 In Liver Pathologymentioning

confidence: 99%

Oncofetal proteins in autoimmune- like hepatitis induced by herbals: a case report

Tomova¹,

Pishmisheva²,

Ivanova³

et al. 2015

MedInform

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We present a 56-years-old patient with a clinical and biochemical picture of acute hepatitis, but for the fourth time in her life after an eighteen-years period with normal liver tests. The patient had also had concomitant increase in alpha-fetal protein (AFP). After exclusion of viral hepatitis, hemochromatosis and liver cancer, we assumed the diagnosis of autoimmune-like hepatitis, probably caused by a twoyears intake of herbals -Samento and Echinacea. The conducted image investigations did not fiound cancer, despite the increased vitamin B12 level and carbohydrate antigen CA19-9. The histological pattern of damage resembled autoimmune cirrhosis, without convincing biological data for autoimmune hepatitis and clinical signs of cirrhosis. Treatment with corticosteroids and imuran (azathioprine) led to normalization of liver transaminases, vitamin B12 and ferritin levels. Increased levels of AFP, usually slight, haved been reported in acute viral and autoimmune hepatitis, and during Echinacea intake. Elevated CA 19-9 have alsod been also reported in single cases of autoimmune hepatitis and in benign conditions. In our patient both tumour markers were increased, most likely due to the autoimmune-like hepatitis, induced by the taken herbals. After initiation of therapy, AFP quickly reached the normal level, while CA 19-9 decreased slowly during the follow-up. One year later the liver histology was similar to the initial one.

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Persistent elevation of serum CA 19-9 with no evidence of malignant disease

Cited by 64 publications

References 36 publications

Serum CA 19-9 as a Biomarker for Pancreatic Cancer—A Comprehensive Review

Serum CA 19-9 as a Biomarker for Pancreatic Cancer—A Comprehensive Review

Capsule Endoscopy Detection of Ileal Mucosa Alterations due to Cow Milk Malabsorption in a Celiac Patient

Oncofetal proteins in autoimmune- like hepatitis induced by herbals: a case report

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