Persistent joint swelling and borrelia-specific antibodies in Borrelia garinii-infected mice after eradication of vegetative spirochetes with antibiotic treatment

Yrjänäinen, Heta; Hytönen, Jukka; Söderström, Karl‐Ove; Oksi, Jarmo; Hartiala, Kaija; Viljanen, Matti K.

doi:10.1016/j.micinf.2006.03.008

Cited by 19 publications

(26 citation statements)

References 28 publications

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“…Studies of the effects of antibiotic therapy in animals infected with B. burgdorferi have been conducted most often with mice (8,18,25,30,31,35,38,53,54) but also with hamsters (21,22), gerbils (15,32,42), dogs (48,49), and nonhuman primates (39). In most of the studies the animals were immunocompetent, but in several the animals were immunocompromised (25,37,48).…”

Section: Animal Studies: General Remarksmentioning

confidence: 99%

Antibiotic Treatment of Animals Infected withBorrelia burgdorferi

Wormser

Schwartz

2009

Clin Microbiol Rev

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SUMMARY Despite resolution of the objective manifestations of Lyme disease after antibiotic treatment, a minority of patients have fatigue, musculoskeletal pain, and/or difficulties with concentration or short-term memory of uncertain etiology; these are called post-Lyme disease symptoms or, in more severe cases, post-Lyme disease syndrome or “chronic Lyme disease.” Several recent studies in which Borrelia burgdorferi-infected animals were treated with antibiotic therapy have demonstrated the presence of PCR positivity for B. burgdorferi DNA in the absence of culture positivity. In mice that were treated with antibiotic therapy, residual spirochetes could be taken up by ticks during a blood meal and could be transmitted to SCID mice. These spirochetes are attenuated; their presence is not associated with either inflammation or disease. In this review the methodology and findings of these studies are critically analyzed, and the significance of the results with regard to human Lyme disease is evaluated, with special emphasis on whether these studies provide useful insights into post-Lyme disease syndrome. A serious methodological concern is the failure to consider the pharmacokinetic-pharmacodynamic properties of the antibiotic in choosing the dosage regimen used. We conclude that there is no scientific evidence to support the hypothesis that such spirochetes, should they exist in humans, are the cause of post-Lyme disease syndrome.

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Section: Animal Studies: General Remarksmentioning

confidence: 99%

Antibiotic Treatment of Animals Infected withBorrelia burgdorferi

Wormser

Schwartz

2009

Clin Microbiol Rev

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“…We have recently developed a mouse model for chronic B. burgdorferi infection [28]. In this model, joint swelling and antibodies against B. burgdorferi persist despite eradication of spirochetes with ceftriaxone in late infection.…”

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confidence: 99%

Anti–Tumor Necrosis Factor–α Treatment ActivatesBorrelia burgdorferiSpirochetes 4 Weeks after Ceftriaxone Treatment in C3H/He Mice

et al. 2007

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“…The development of joint manifestations was monitored by periodical measuring the mediolateral diameter of the hind tibiotarsal joints using a metric caliper. At the end of the experiment, the mice were sacrificed, and their infection status was assessed by measuring serum borrelia-specific IgG Abs and culturing samples from the ear lobe, urinary bladder, and hind tibiotarsal joints for spirochete recovery, as described earlier (23).…”

Section: Experimental Designsmentioning

confidence: 99%

“…Joint inflammation and dysfunction are consequences of bacterial invasion into the joint, and chronic Lyme arthritis has been considered a hallmark of late-stage disease (17). Various mouse strains develop mild or severe symptoms of inflammation and joint swelling several weeks after borrelia inoculation, thus providing a good experimental model for studying the pathogenesis of persistent infection and subacute Lyme arthritis most commonly seen in humans (20)(21)(22)(23).…”

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confidence: 99%