Persistent luminescent metal-organic frameworks with long-lasting near infrared emission for tumor site activated imaging and drug delivery

Persistent luminescence phosphors are a novel group of promising luminescent materials with afterglow properties after the stoppage of excitation. In the past decade, persistent luminescence nanoparticles (PLNPs) with intriguing optical properties have attracted a wide range of attention in various areas. Especially in recent years, the development and applications in biomedical fields have been widely explored. Owing to the efficient elimination of the autofluorescence interferences from biotissues and the ultra-long near-infrared afterglow emission, many researches have focused on the manipulation of PLNPs in biosensing, cell tracking, bioimaging and cancer therapy. These achievements stimulated the growing interest in designing new types of PLNPs with desired superior characteristics and multiple functions. In this review, we summarize the works on synthesis methods, bioapplications, biomembrane modification and biosafety of PLNPs and highlight the recent advances in biosensing, imaging and imaging-guided therapy. We further discuss the new types of PLNPs as a newly emerged class of functional biomaterials for multiple applications. Finally, the remaining problems and challenges are discussed with suggestions and prospects for potential future directions in the biomedical applications.

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Section: Plnps-based Photodynamic Therapymentioning

confidence: 99%

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

Ding

et al. 2020

Nano-Micro Lett.

142

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“…In addition, the developed nanoplatform exhibited the excellent pH-responsive drug release and generation of ROS for enhanced cancer treatment [119]. Zhao et al [120] reported a luminescent PLNP@ZIF-8 MOF with durable luminescence of near-infrared, which facilitates tumor site activated luminescence imaging. A surface adsorption induced self-assembly method was used to construct PLNP@ZIF-8 at room temperature ( Figure 7) [120].…”

Section: Mofs For Drug Deliverymentioning

confidence: 99%

“…Zhao et al [120] reported a luminescent PLNP@ZIF-8 MOF with durable luminescence of near-infrared, which facilitates tumor site activated luminescence imaging. A surface adsorption induced self-assembly method was used to construct PLNP@ZIF-8 at room temperature ( Figure 7) [120]. The PLNP@ZIF-8 MOF produced persistence NIR luminescence for hours or even days and thus enabled background interference-free long-term and deep tissue penetration and imaging without external irradiation.…”

Section: Mofs For Drug Deliverymentioning

confidence: 99%

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Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

et al. 2020

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Metal-organic frameworks (MOFs) are a fascinating class of porous crystalline materials constructed by organic ligands and inorganic connectors. Owing to their noteworthy catalytic chemistry, and matching or compatible coordination with numerous materials, MOFs offer potential applications in diverse fields such as catalysis, proton conduction, gas storage, drug delivery, sensing, separation and other related biotechnological and biomedical applications. Moreover, their designable structural topologies, high surface area, ultrahigh porosity, and tunable functionalities all make them excellent materials of interests for nanoscale applications. Herein, an effort has been to summarize the current advancement of MOF-based materials (i.e., pristine MOFs, MOF derivatives, or MOF composites) for electrocatalysis, photocatalysis, and biocatalysis. In the first part, we discussed the electrocatalytic behavior of various MOFs, such as oxidation and reduction candidates for different types of chemical reactions. The second section emphasizes on the photocatalytic performance of various MOFs as potential candidates for light-driven reactions, including photocatalytic degradation of various contaminants, CO2 reduction, and water splitting. Applications of MOFs-based porous materials in the biomedical sector, such as drug delivery, sensing and biosensing, antibacterial agents, and biomimetic systems for various biological species is discussed in the third part. Finally, the concluding points, challenges, and future prospects regarding MOFs or MOF-based materials for catalytic applications are also highlighted.

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“…Among different types of porous materials, silica, calcium carbonate, calcium phosphate, and metal-organic frameworks (MOFs) have received significant attention in the last decade [10]. Although they are in the early stages of development [11,12], MOFs, wherein metal ions or clusters link organic ligands into porous materials, have shown great promise as a novel nanomedicine platform due to its large surface area, adjustable pore size, tunable host-guest interaction, and versatile functionality [13,14]. Preliminary biomedical applications of MOFs have focused on their use as delivery vehicles for molecular therapeutics and as viable contrast agents for optical imaging, multimodal imaging or X-ray computed tomography imaging [15,16].…”

Section: Introductionmentioning

confidence: 99%

Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Gao

et al. 2020

Pharmaceutics

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Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.

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Persistent luminescent metal-organic frameworks with long-lasting near infrared emission for tumor site activated imaging and drug delivery

Cited by 97 publications

References 38 publications

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

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