Persistent Pruritic Papules AND Plaques and Flagellate Erythema as Presenting Manifestations of an Adult onset Still's Disease

Pawar, Manoj; Zawar, V; Kumavat, Shrikant

doi:10.1016/j.adengl.2020.09.013

Cited by 2 publications

(4 citation statements)

References 9 publications

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Section: Discussionmentioning

confidence: 99%

“…Moreover, flagellate erythema may serve as a poor prognostic sign in AOSD conferring longer chronicity, more internal organ complications, resistance to therapy, possible underlying malignancy, and higher mortality. 4,5 Thus, early recognition of this finding is critical in preventing morbidity and mortality. 4,5 Our patient was treated with colchicine and ibuprofen for the pericarditis, as well as 80 mg of intravenous methylprednisolone daily for 3 days followed by an 8-week oral prednisone taper starting at 60 mg daily.…”

Section: Histopathologic Findingsmentioning

confidence: 99%

“…4,5 Thus, early recognition of this finding is critical in preventing morbidity and mortality. 4,5 Our patient was treated with colchicine and ibuprofen for the pericarditis, as well as 80 mg of intravenous methylprednisolone daily for 3 days followed by an 8-week oral prednisone taper starting at 60 mg daily. At follow-up 1 month later, there was significant clinical improvement of all symptoms and laboratory abnormalities.…”

Section: Histopathologic Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Flagellate erythema with relapsing fevers and arthralgia

McNamara,

Henehan,

Zubair

et al. 2023

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Histopathologic Findingsmentioning

confidence: 99%

Section: Histopathologic Findingsmentioning

confidence: 99%

See 1 more Smart Citation

Flagellate erythema with relapsing fevers and arthralgia

McNamara,

Henehan,

Zubair

et al. 2023

Int J Dermatology

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“…There is a growing body of evidence describing the atypical eruption of persistent, pruritic papules and plaques in patients with AOSD. [2][3][4][5][6][7][8] These persistent lesions have characteristic findings on histology, including dyskeratotic cells in the upper epidermis and a lymphocytic infiltrate in the papillary dermis. 2 In patients who develop linear lesions with the appearance of excoriations, as seen in our patient, histology remains consistent, and this therefore represents Koebner's phenomenon.…”

Section: Introduction Case Presentationmentioning

confidence: 99%

Adult-Onset Still’s Disease with an Atypical Cutaneous Manifestation

et al. 2022

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Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder, characterized by daily fevers, arthralgias, and rash without evidence of infection. Recently there has been a growing number of cases reported with atypical cutaneous manifestations. We present a 37-year-old type VI Fitzpatrick skin type female who was seen in the hospital for a pruritic rash on her chest, back, and legs. Skin examination was significant for hyperpigmented papules coalescing into plaques on the chest, and hyperpigmented linear patches and excoriated plaques on the back and legs. Punch biopsy showed acanthosis and numerous apoptotic keratinocytes in the upper layers of the epidermis, which was characteristic of AOSD. As of recently, there is a growing body of evidence describing an atypical eruption of persistent, pruritic papules and plaques with typical histologic findings of AOSD. Further, these atypical features may be associated with more severe symptoms, higher incidence of macrophage activation syndrome, and possible delayed malignancy. Due to the scarcity of atypical cutaneous manifestations reported in the literature, these eruptions have not been included in the diagnostic criteria and can therefore be overlooked and misdiagnosed. Prompt recognition of these atypical eruptions is imperative to prevent a worsening prognosis and serious adverse effects.

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Persistent Pruritic Papules AND Plaques and Flagellate Erythema as Presenting Manifestations of an Adult onset Still's Disease

Cited by 2 publications

References 9 publications

Flagellate erythema with relapsing fevers and arthralgia

Flagellate erythema with relapsing fevers and arthralgia

Adult-Onset Still’s Disease with an Atypical Cutaneous Manifestation

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