Persistent <scp>post–COVID</scp>‐19 neuromuscular symptoms

Abrams, Rory; Zhou, Lan; Shin, Susan

doi:10.1002/mus.27940

Cited by 6 publications

(1 citation statement)

References 53 publications

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“…However, nerve conduction studies are usually not abnormal in many patients. SFN is suspected in such cases and has been reported after the novel coronavirus infection [35,36].…”

Section: Numbnessmentioning

confidence: 99%

Evaluation of diseases complicating long COVID: A retrospective chart review

Tsuchida,

Hirose,

Fujii

et al. 2024

Preprint

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Purpose Evidence for the pathogenesis and treatment of post-acute coronavirus disease 2019 (COVID-19) (long COVID) is lacking. As long COVID symptoms are predicted to have an impact on the global economy, clarification of the pathogenesis is urgently needed. Our experiences indicated that some symptoms were complicated by diseases established before the COVID-19 pandemic. Methods Using a retrospective, cross-sectional study, we aimed to evaluate the diseases complicating long COVID. Using the medical records of patients with confirmed severe acute respiratory syndrome coronavirus 2 infection exhibiting residual symptoms lasting ≥ 60 days post-infection who visited our clinic in January 2021–February 2023, we investigated the symptoms and diseases observed. We identified diseases that occurred after COVID-19 infection and excluded those that were exacerbations of existing diseases. Results: During the first visit, the most common symptoms reported in a total of 798 patients were fatigue (523 patients), anxiety (349 patients), and lack of motivation (344 patients). Complicating diseases were observed in 452 patients (57%). There were 115, 65, and 60 patients with postural tachycardia syndrome, postural syndrome without tachycardia, and mood disorders, respectively. Some diseases requiring immediate treatment included pulmonary thromboembolism, purulent shoulder arthritis, cerebellopontine angle tumors, myasthenia gravis, and cervical myelopathy. Conclusion All symptoms that occur after COVID-19 infection should not be treated as long COVID. Similar to normal medical treatment, a list of differential diagnoses should be maintained based on symptoms to obtain definitive diagnoses.

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“…However, nerve conduction studies are usually not abnormal in many patients. SFN is suspected in such cases and has been reported after the novel coronavirus infection [35,36].…”

Section: Numbnessmentioning

confidence: 99%

Evaluation of diseases complicating long COVID: A retrospective chart review

Tsuchida,

Hirose,

Fujii

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Evaluation of diseases complicating long COVID: A retrospective chart review

Tsuchida,

Hirose,

Fujii

et al. 2024

J of Gen and Family Med

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BackgroundEvidence for the pathogenesis and treatment of postacute coronavirus disease 2019 (COVID‐19) (long COVID) is lacking. As long COVID symptoms are predicted to have an impact on the global economy, clarification of the pathogenesis is urgently needed. Our experiences indicated that some symptoms were complicated by diseases established before the COVID‐19 pandemic.MethodsUsing a retrospective, cross‐sectional study, we aimed to evaluate the diseases complicating long COVID. Using the medical records of patients with confirmed COVID‐19 exhibiting residual symptoms lasting ≥60 days postinfection who visited our clinic in January 2021–February 2023, we investigated the symptoms and diseases observed. We identified diseases that occurred after COVID‐19 and excluded those that were exacerbations of existing diseases.ResultsDuring the first visit, the most common symptoms reported in a total of 798 patients were fatigue (523 patients), anxiety (349 patients), and lack of motivation (344 patients). Complicating diseases were observed in 452 patients (57%). There were 115, 65, and 60 patients with postural tachycardia syndrome, postural syndrome without tachycardia, and mood disorders, respectively. Some diseases requiring immediate treatment included pulmonary thromboembolism, purulent shoulder arthritis, cerebellopontine angle tumors, myasthenia gravis, and cervical myelopathy.ConclusionNot all symptoms that occur after COVID‐19 should be treated as long COVID. Similar to normal medical treatment, a list of differential diagnoses should be maintained based on symptoms to obtain definitive diagnoses.

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Non‐Hospitalized Patients With Post‐COVID Condition and Myopathic Electromyography Findings Show no Difference in Symptom Severity and Clinical Manifestations Compared to Those Without Myopathic Findings

Sepic,

Tryfonos,

Rundqvist

et al. 2024

Muscle and Nerve

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IntroductionThe COVID‐19 pandemic has resulted in a post‐infectious syndrome designated as long‐COVID or post‐COVID condition (PCC) that presents with numerous symptoms including fatigue and myalgias. This study evaluated myopathic electromyography (EMG) findings in non‐hospitalized PCC patients in relation to symptom severity, quality of life (QoL), and physical function.MethodsTwenty‐nine PCC patients with persistent symptoms ≥ 3 months after laboratory‐confirmed SARS‐CoV‐2 infection, without hospitalization or comorbidities, were included. EMG, nerve conduction studies (NCS), and quantitative sensory testing (QST) were performed. Symptom severity was measured with visual analog scales, QoL with validated questionnaires, and physical function with the 6‐min walk test, cardiopulmonary exercise testing, handgrip strength, and isokinetic dynamometry.ResultsMyopathic findings on EMG were present in 62% of PCC patients (n = 18). Symptom severity (muscle pain and fatigue) and QoL (physical function and fatigue) were similar between patients with and without myopathic EMG findings. The 6‐min walk test (457 ± 81 vs. 459 ± 86 m) and peak VO2 (29 ± 9 vs. 28 ± 6 mL/kg/min) were similar between patients with and without myopathic EMG findings. Handgrip strength (32 [29–43] vs. 33 [29–50] kg) and quadriceps muscle strength (136 [111–191] vs. 136 [114–184] Nm) were comparable between the groups. NCS and QST results were normal in all patients.DiscussionMyopathic findings on EMG are common in PCC patients, but no significant differences in symptom severity, QoL, or physical function were found between those with and without myopathic EMG findings. Myopathic EMG changes in PCC patients should be interpreted with caution, considering the overall clinical context.

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Persistent post–COVID‐19 neuromuscular symptoms

Cited by 6 publications

References 53 publications

Evaluation of diseases complicating long COVID: A retrospective chart review

Evaluation of diseases complicating long COVID: A retrospective chart review

Evaluation of diseases complicating long COVID: A retrospective chart review

Non‐Hospitalized Patients With Post‐COVID Condition and Myopathic Electromyography Findings Show no Difference in Symptom Severity and Clinical Manifestations Compared to Those Without Myopathic Findings

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