Persistent Wnt/β‐Catenin Signaling Determines Dorsalization of the Postnatal Subventricular Zone and Neural Stem Cell Specification into Oligodendrocytes and Glutamatergic Neurons

Azim, Kasum; Fischer, Bruno; Hurtado-Chong, Anahí; Draganova, Kalina; Cantù, Claudio; Zemke, Martina; Sommer, Lukas; Butt, Arthur M.; Raineteau, Olivier

doi:10.1002/stem.1639

Cited by 79 publications

(124 citation statements)

References 34 publications

(86 reference statements)

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“…6A-C). Similarly, canonical Wnt signaling is active exclusively in the dorsal V-SVZ and within dorsally derived lineages (Ortega et al, 2013;Azim et al, 2014b), in agreement with its described role in dorsalization and caudalization of the developing telencephalon (Lee et al, 2000;Muzio et al, 2005;Hoch et al, 2009) (Fig. 6A-C).…”

Section: Spatial Patterns In the V-svz Provide Insights Into The Mechsupporting

confidence: 85%

“…For example, antagonists of the Wnt signaling pathway are highly upregulated with aging and their ablation reverses the agerelated decline in neurogenesis (Seib et al, 2013). In the case of the V-SVZ, microdissection of defined microdomains followed by RNA or protein extraction can be performed to study the differential expression of TFs and/or the activity of signaling pathways (Azim et al, 2014b(Azim et al, , 2015 (Fig. 6D).…”

Section: Beyond Space: Adding the Temporal Dimensionmentioning

confidence: 99%

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Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis

et al. 2015

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Neurogenesis does not stop abruptly at birth, but persists in specific brain regions throughout life. The neural stem cells (NSCs) located in the largest germinal region of the forebrain, the ventricularsubventricular zone (V-SVZ), replenish olfactory neurons throughout life. However, V-SVZ NSCs are heterogeneous: they have different embryonic origins and give rise to distinct neuronal subtypes depending on their location. In this Review, we discuss how this spatial heterogeneity arises, how it affects NSC biology, and why its consideration in future studies is crucial for understanding general principles guiding NSC self-renewal, differentiation and specification.

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Section: Spatial Patterns In the V-svz Provide Insights Into The Mechsupporting

confidence: 85%

Section: Beyond Space: Adding the Temporal Dimensionmentioning

confidence: 99%

Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis

et al. 2015

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“…Activation of -catenin signaling increases the numbers of oligodendrocytes derived from this neurogenic site, while inhibition seems to reduce the glial cell number [142]. In another study, -catenin activation via GSK-3 inhibition increased cell proliferation in the SVZ, and this was accompanied by increased numbers of oligodendrocytes [143], confirming an earlier study that highlighted oligodendrocytic genes as targets of -catenin [144]. Thus, Wnt/ -catenin signaling may also play important roles in the proliferation of progenitors and in oligodendrocytic development in the SVZ.…”

Section: Wnt Signaling and Adult Neurogenesis: Intracellular Componentsmentioning

confidence: 94%

Canonical and noncanonical Wnt signaling in neural stem/progenitor cells

Bengoa-Vergniory

Kypta

2015

Cell. Mol. Life Sci.

138

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“…Nevertheless, it has been shown that several specific signaling are different between compartments. For example, the Wnt family of soluble ligands regulates the self-renewal of a small population of V-SVZ astrocytes, which are located in the dorsal compartment and generate glutamatergic olfactory bulb neurons (Azim et al 2014). Another example is the sonic hedgehog (Shh) signaling.…”

Section: Introductionmentioning

confidence: 99%

The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell

Platel

Bordey²

2016

Neuroscience

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A few decades ago it was discovered that two regions of the adult brain retain the ability to generate new neurons. These regions include the subgranular zone of the hippocampal dentate gyrus and the ventricular-subventricular zone (V-SVZ) located at the border of the lateral ventricle. In the V-SVZ, it was discovered that neural progenitor cells share many features of mature astrocytes and are often referred as V-SVZ astrocytes. We will first describe the markers, the morphology, and the neurophysiological characteristics of V-SVZ astrocytes. We will then discuss the fact that V-SVZ astrocytes constitute a mixed population with respect to their neurogenic properties, e.g., quiescent versus activated state, neurogenic fate, and transcription factors expression. Finally, we will describe two functions of V-SVZ astrocytes, their metabolic coupling to blood vessels and their neurogenic supportive role consisting of providing guidance and survival cues to migrating newborn neurons.

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Persistent Wnt/β‐Catenin Signaling Determines Dorsalization of the Postnatal Subventricular Zone and Neural Stem Cell Specification into Oligodendrocytes and Glutamatergic Neurons

Abstract: ABSTRACT

Cited by 79 publications

References 34 publications

Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis

Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis

Canonical and noncanonical Wnt signaling in neural stem/progenitor cells

The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell

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