Persistently elevated circulating Th22 reversely correlates with prognosis in HBV‐related acute‐on‐chronic liver failure

Mo, Ruidong; Wang, Peng; Lai, Rongtao; Li, Fanlu; Liu, Yuhan; Jiang, Shaosong; Zhao, Guijun; Guo, Simin; Zhou, Huidi; Lin, Lingnan; Lu, Jie; Cai, Wei; Wang, Hui; Yu, Hong; Bao, Shisan; Xiang, Xiaogang; Xie, Qing

doi:10.1111/jgh.13537

Cited by 22 publications

(21 citation statements)

References 49 publications

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“…Foxp3+ Tregs are well-known immunoregulatory cells, and have been found significantly enhanced during chronic HBV infection 24 . Importantly, the suppressive effect of Following Th17 populations are identified, a number of studies have reported that the changes of Treg/Th17, Th1/Th17, and Th22/Th17 ratios are associated with the progression of HBV infection 6,7,30 . In the present study, we found a significant increased Th1/Th9 proportion, and direct relationship between Th1/Th9 ratios and HBV DNA loads in CHB patients, suggesting that persisting HBV infection can induce a wide variety of disorders of CD4+ T cell immune responses.…”

Section: Discussionmentioning

confidence: 99%

Decreased frequency of circulating Th9 cells in patients with chronic hepatitis B infection

Cui

et al. 2017

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 99%

Decreased frequency of circulating Th9 cells in patients with chronic hepatitis B infection

Cui

et al. 2017

Clinical Laboratory Analysis

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“…IL-22, mainly manufactured by hepatic γδ T cells is shown to attenuate liver injury in case of adenovirus-infected murine model ( 121 ). In contrast with IL-22 beneficiary effect, its association with prognosis in chronic liver inflammation, fibrosis and Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) have also been studied ( 122 – 124 ). HCV induced IL-22 up-regulation in liver cells does not itself regulate antiviral proteins and HCV replication in cell lines ( 125 ).…”

Section: Il-22 Biological Effectsmentioning

confidence: 99%

A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

et al. 2020

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Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.

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“…Western blot was performed as described previously [ 17 ]. Briefly, liver tissues were lysed in RIPA buffer (Beyotime, China), and extracted proteins were quantified using a BCA assay (Beyotime, China).…”

Section: Methodsmentioning

confidence: 99%

Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients

Chen

Zhu

et al. 2018

Cell Biosci

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BackgroundChronic hepatitis B (CHB) remains a global health dilemma with high morbidity and mortality. Human males absent on the first (hMOF) (a histone acetyltransferase) is responsible for DNA damage repair, tumorigenesis and cell cycle regulation. Persistence of HBV DNA contributes to cirrhosis and hepatocellular carcinoma (HCC) in CHB patients. Histone acetyltransferase enhances HBV replication, however the precise underlying mechanism of hMOF in HBV replication in CHB patients remains to be explored. This study aims to investigate the correlation between hepatic hMOF and HBV DNA replication in CHB patients, and may provide new insights towards the treatment of CHB patients.MethodshMOF in liver biopsy (CHB, n = 33 HBeAg+; n = 20 HBeAg−, and three healthy controls) was determined, using immunohistochemistry, qPCR and Western blot. The correlation between hMOF and HBsAg, as well as, HBeAg were determined.ResultsA positive correlation between hMOF and HBV DNA in overall CHB patients was observed. A distinct positive correlation between hMOF and HBsAg and/or HBeAg in HBeAg+ CHB patients was also detected, however not observed between hMOF and HBsAg in HBeAg− CHB patients. No correlation was observed between hMOF and hepatic inflammation severity and fibrotic stage in CHB patients.ConclusionsHepatic hMOF might contribute to host HBV clearance in CHB patients and possible pathogenesis.Electronic supplementary materialThe online version of this article (10.1186/s13578-018-0215-5) contains supplementary material, which is available to authorized users.

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Persistently elevated circulating Th22 reversely correlates with prognosis in HBV‐related acute‐on‐chronic liver failure

Abstract: Persistently elevated circulating Th22 reversely correlates with prognosis in HBV-ACLF. Th22 cells/IL-22 might be served as biomarkers for evaluating the prognosis of HBV-ACLF.

Cited by 22 publications

References 49 publications

Decreased frequency of circulating Th9 cells in patients with chronic hepatitis B infection

Decreased frequency of circulating Th9 cells in patients with chronic hepatitis B infection

A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients

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