Persisting alveolar sockets—a radiologic symptom of BP-ONJ?

Groetz, Knut A.; Al‐Nawas, Bilal

doi:10.1016/j.joms.2006.05.041

Cited by 45 publications

(21 citation statements)

References 2 publications

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“…In some cases we found the ''persisting alveolar socket'' (Fig. 3b) what has been described as a typical radiographic feature of ONJ (Groetz and Al-Nawas, 2006).…”

Section: Radiological and Histopathological Examinationmentioning

confidence: 57%

“Bis-phossy jaws” – High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw

Abu-Id

Warnke

Gottschalk

et al. 2008

Journal of Cranio-Maxillofacial Surgery

197

131

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“…In some cases we found the ''persisting alveolar socket'' (Fig. 3b) what has been described as a typical radiographic feature of ONJ (Groetz and Al-Nawas, 2006).…”

Section: Radiological and Histopathological Examinationmentioning

confidence: 57%

“Bis-phossy jaws” – High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw

Abu-Id

Warnke

Gottschalk

et al. 2008

Journal of Cranio-Maxillofacial Surgery

197

131

View full text Add to dashboard Cite

“…Even though within the normal parameters, the BRONJ group had higher levels of alkaline phosphatase than the non-BRONJ group, and a positive correlation was identified between alkaline phosphatase and persisting alveolar socket. Taking into account that this is a 46,53,58 this finding would suggest that alkaline phosphatase increases with BRONJ occurrence and therefore, it could be a marker of the disease. Nevertheless, this enzyme lacks specificity, since changes in its levels are also attributed to other factors such as bone activity, cancer and impaired liver function.…”

Section: Discussionmentioning

confidence: 89%

Interrelationship of clinical, radiographic and haematological features in patients under bisphosphonate therapy

Koth

Figueiredo

Salum

et al. 2017

Dentomaxillofacial Radiology

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Objectives: To analyze the clinical, radiographic and haematological aspects of patients under bisphosphonate therapy. Methods: A retrospective study was conducted where the records of patients taking bisphosphonates were analyzed considering the occurrence of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Evaluation included panoramic and periapical radiographies, haematological examinations and clinical features. Radiographies were analyzed determining the presence or absence of bone sclerosis, osteolysis, persisting alveolar socket, narrowing of the mandibular canal, widening of the periodontal ligament space, periradicular radiolucency, sequestrum and thickening of the lamina dura. Laboratory tests consisted of complete blood count, fasting serum glucose, erythrocyte sedimentation rate (ESR) and serum levels of calcium, phosphorus, alkaline phosphatase, parathormone (PTH) and C-terminal telopeptide of collagen I (CTX). Results: Alkaline phosphatase and ESR were significantly higher in the BRONJ group, whereas fasting serum glucose, CTX, PTH, calcium and phosphorus did not significantly differ. BRONJ showed association with smoking, tooth extraction, anaemia and leukocytosis. On radiographic analysis, persisting alveolar socket, osteolysis, bone sclerosis and narrowing of the mandibular canal were significantly more prevalent in the BRONJ group. Thickening of the lamina dura, periapical radiolucencies, widening of the periodontal ligament space and sequestrum did not significantly differ between the groups. Conclusions: BRONJ is a multifactorial disease with high morbidity, which requires experimental studies to clarify the role of the reported risk factors and clinical radiographic signs to improve its diagnosis.

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“…Those features have been described in the existing literature as focal or diffuse osteosclerosis, cortical disruptions, an increased lamina dura thickness and density, lack of bone fill in extraction sides (persisting alveolar socket), prominence of the inferior alveolar canal, periosteal bone formation, sequestration, widening of the periodontal ligament space and the loss of the trabecular structure. [11][12][13][14][15][17][18][19][20][25][26][27] Hutchinson et al 13 came to the conclusion that some of those radiologic signs can appear as early as in Stage 0 of the disease (as defined by the AAOMS) and are the same as seen in later stages. 1 Hutchinson et al were not able to address causality, as the study was of only descriptive character and had no CG.…”

Section: Discussionmentioning

confidence: 99%

Can dental panoramic radiographic findings serve as indicators for the development of medication-related osteonecrosis of the jaw?

Klingelhöffer¹,

Klingelhöffer²,

Müller³

et al. 2016

Dentomaxillofacial Radiology

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Objectives: The purpose of this case-control study was to find a correlation between certain imaging findings in dental panoramic radiographs and the risk for developing a medicationrelated osteonecrosis of the jaw (MRONJ) in patients taking antiresorptive therapy (AT). Methods: Randomized and blinded dental panoramic radiographs of 60 patients undergoing antiresorptive drug treatment (36 patients with MRONJ, 24 patients without MRONJ) and of 60 patients without AT were analyzed by 3 experts for the following signs: sequestrum, osteosclerosis, difference in sclerosing of alveolar process and body of mandible, visible alveolar socket, enhancement and loss of lamina dura, enhancement of the oblique ridge, enhancement of the mandibular canal, proliferative periostitis and osteolytic processes at the cortex. Results: Signs were seen significantly more often in patients undergoing AT than in the control group (CG) (osteosclerosis p-value 5 0.019, visible alveolar socket p-value 5 0.001, enhancement of lamina dura p-value , 0.001, enhancement of the mandibular canal p-value 5 0.025, proliferative periostitis p-value 5 0.05 and osteolytic processes at the cortex p-value , 0.001). While there is no significant difference between the CG and the group of patients with AT without manifest MRONJ for any sign, the significance increases when taking the group of patients under AT with manifest MRONJ into consideration. In addition, if medication was administered for malignant reasons, the signs visible alveolar socket, enhancement of the lamina dura and the enhancement of the mandibular canal were seen significantly more often. Conclusions: The radiographic findings mentioned above are not indicators for the development of MRONJ, as they are seen only in patients with manifest osteonecrosis. However, these findings could be important to assess the dimension and potency of a MRONJ.

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Persisting alveolar sockets—a radiologic symptom of BP-ONJ?

Cited by 45 publications

References 2 publications

“Bis-phossy jaws” – High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw

“Bis-phossy jaws” – High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw

Interrelationship of clinical, radiographic and haematological features in patients under bisphosphonate therapy

Can dental panoramic radiographic findings serve as indicators for the development of medication-related osteonecrosis of the jaw?

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