Personalised deposition maps for micro- and nanoparticles targeting an atherosclerotic plaque: attributions to the receptor-mediated adsorption on the inflamed endothelial cells

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

“…The increased permeability of endothelium and plaque vascularity would allow NC penetration in the vascular wall [104], as recently proved in experimental models of atherosclerosis using lipid-polymer hybrid nanoparticle translocation and liposomal nanoparticles, as reviewed by Kelley et al [104]. NP can be carriers of anti-inflammatory drugs such as celastrol, an NF- κ B inhibitor, as Allen et al demonstrated in a model of atherosclerosis using Ldlr −/− mice [300] or antibodies such as ICAM-1 to target endothelial adhesion proteins in the left anterior descending artery from a patient suspected of coronary heart disease [301]. Strategies for improving the vascular efficacy of nanocarriers are beyond the scope of this review [104], but questions such as NC degradation, inactivation, clearance, or migration should be considered.…”

Effects of sevoflurane and propofol anesthesia on intraoperative endothelial cell function in patients undergoing laparoscopic cholecystectomy

“…8 We did not observe significant changes in TM expression level in patients with sevoflurane anesthesia, which may indicate potential pathological changes in the endothelial cells and changes in vascular endothelial cell function. 9,10 We did not observe significant changes in P-selectin, ICAM-1, and TM expression in the blood of patients undergoing LC with propofol anesthesia compared with the preoperative resting state. The results indicate that propofol might not induce an inflammatory response, but sevoflurane anesthesia induces functional changes in endothelial cells.…”

The convergence of nanotechnology‐stem cell, nanotopography‐mechanobiology, and biotic‐abiotic interfaces: Nanoscale tools for tackling the top killer, arteriosclerosis, strokes, and heart attacks

“…These forces tempt functional regulation progression and affect the expression of gene and protein. [ 131 ] It was highlighted here that non‐coding, RNAs, and microRNAs take part in vascular remodeling development. Mechanotransduction triggers a cascade reaction route through the complex signaling networks in cells.…”