Perspective for Molecular Dynamics Simulation Studies of Amyloid-β Aggregates

Can local heating and molecular crowders disintegrate amyloid aggregates?

“…2 Many other similar studies using experiments and molecular dynamics simulation studies have been performed to get more insight into the structural aspects of Aβ peptide and AD. 22–28 A very recent study reports that external electric or magnetic fields can disintegrate the Aβ oligomers and maybe a potential strategy to treat Alzheimer's patients. 21 Similarly, different strategies to disintegrate the amyloid aggregates have been reported, e.g.…”