Perspectives of vector management in the control and elimination of vector-borne zoonoses

Wong, Meng Li; Zulzahrin, Zulhisham; Vythilingam, Indra; Lau, Yee Ling; Sam, I‐Ching; Fong, Mun Yik; Lee, Wenn-Chyau

doi:10.3389/fmicb.2023.1135977

Cited by 3 publications

(1 citation statement)

References 438 publications

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“…Переносниками борелій від тварини до людини зазвичай є іксодові кліщі [2]. Борелії містяться в кишківнику заражених кліщів і зі слиною потрапляють у місце їх присмоктування.…”

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Borrelial Lymphocytoma in a Child. Clinical Case

Lytvyn,

Nadragа,

Zinchuk

et al. 2024

Buk. Med. Herald

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Lyme borreliosis is a multisystem infectious disease caused by bacteria of the Borrelia burgdorferi sensu lato complex.The course of the disease is characterized by three stages: early localized, early disseminated and late disseminated. One of the rare forms of the early disseminated stage of Lyme disease in children is lymphocytoma.We present a clinical case of borrelial lymphocytoma caused by a combination of three types of Borrelia (Borrelia afzelii, Borrelia burgdorferi, Borrelia garinii) in a 6-year-old girl. The disease manifested as multiple migratory erythema on the child's face, mistaken for allergic dermatitis. According to the parents, the child had no history of tick bites. The diagnosis was confirmed by the ELISA method and immunoblot analysis. The patient was prescribed a 21-day course of doxycycline at 50 mg twice daily. Three weeks after the initiation of antibiotic therapy, complete regression of the lymphocytoma was observed. The purpose of the study is to draw the attention of doctors of various specialties to rare forms of Lyme borreliosis against the background of the absence of a verified fact of tick bite.Material and methods. Confirmation of the diagnosis by ELISA and immunoblot analysis.Research results. A clinical case of borrelial lymphocytoma caused by a combination of three Borrelia species (Borrelia afzelii, Borrelia burgdorferi, Borrelia garinii) in a 6-year-old girl is presented. The disease manifested as multiple migratory erythema in the area of the child's face, which was mistaken for allergic dermatitis. According to the parents, the child had no history of a tick bite. The diagnosis was confirmed by ELISA and immunoblot analysis. The patient was prescribed doxycycline treatment for 21 days at 50 mg twice a day. Three weeks after the start of antibiotic therapy, a complete regression of the lymphocytoma was observed.Conclusions. Doctors of various specialties have difficulties in diagnosing Lyme disease in its various stages, especially in children with a heavy allergic history. With the presented clinical case, we want to emphasize the importance of early and timely diagnosis of Lyme borreliosis, in particular, in the absence of an episode of tick bite in the anamnesis.

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Section: вступunclassified

Borrelial Lymphocytoma in a Child. Clinical Case

Lytvyn,

Nadragа,

Zinchuk

et al. 2024

Buk. Med. Herald

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Animal and Human Interaction Through the Cultural Prism

Khan,

Pandey

2024

Pathogens and Environmental Impact on Life Forms

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Genetic characterization of immune adaptor molecule MyD88 in Culex pipiens complex (Diptera: Culicidae) mosquitoes from China

Wang,

Zhu,

Huo

et al. 2024

Journal of Medical Entomology

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Mosquitoes of the Culex (Cx.) pipiens complex are vectors of severe diseases including West Nile fever by West Nile virus, Japanese encephalitis by Japanese encephalitis virus, and Lymphatic filariasis by filarial nematode Wuchereria bancrofti. As a major portion of mosquito immune system, the Toll pathway implicates in response against infections of mosquito-borne pathogens and biocontrol agents. The genetic diversity of immune-related molecules is expected to be a feasible and effective introduction to expand our knowledge of the mosquito-microbe interplay. However, a comprehensive description is currently lacking regarding the genetic characteristic of the Toll pathway molecules in Cx. pipiens complex mosquitoes. In the present study, genetic changes in Cx. pipiens complex MyD88 (Myeloid differentiation primary response protein 88) were analyzed as a precedent for the Toll pathway molecules in this taxon. MyD88 is a critical adaptor of the pathway transducing signals from TIR-containing receptors to downstream death domain-containing molecules. Our results revealed that adaptive selection has influenced the genetic changes of the molecule, giving rise to acceleration of diversity at a number of amino acid sites. The adaptively selected sites lie in the death domain, intermediate domain, and C-terminal extension. The characteristics of the genetic changes shed insights into the prominent molecular-level structural basis and the involvement strategy of the adaptor in the arms race against exogenous challenges. This finding would be beneficial for further exploration and deeper understanding of the mosquitoes’ vectorial capacity and facilitating the effectiveness and sustainability of the biocontrol agents.

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Perspectives of vector management in the control and elimination of vector-borne zoonoses

Cited by 3 publications

References 438 publications

Borrelial Lymphocytoma in a Child. Clinical Case

Borrelial Lymphocytoma in a Child. Clinical Case

Animal and Human Interaction Through the Cultural Prism

Genetic characterization of immune adaptor molecule MyD88 in Culex pipiens complex (Diptera: Culicidae) mosquitoes from China

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