Perturbation in Mitochondrial Network Dynamics and in Complex I Dependent Cellular Respiration in Schizophrenia

Rosenfeld, Marina; Brenner-Lavie, Hanit; Ari, Shunit Gal-Ben; Kavushansky, Alexandra; Ben‐Shachar, Dorit

doi:10.1016/j.biopsych.2011.01.010

Cited by 127 publications

(87 citation statements)

References 79 publications

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“…values for the cytotoxic effects of CPZ is similar to the value reported for its direct inhibitory effect on the activity of Complex I in isolated rat brain mitochondria: IC50 of <5µM (Rosenfeld et al, 2011). Together, this evidence suggests that for CPZ to achieve a potency in HBMECs similar to that observed for its inhibition of Complex I in isolated mitochondria the drug must have easy access to the cytosol.…”

Section: Mechanisms Of Cytotoxicitysupporting

confidence: 77%

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood–brain barrier

et al. 2014

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Section: Mechanisms Of Cytotoxicitysupporting

confidence: 77%

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood–brain barrier

et al. 2014

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“…Among the possible mechanisms involved, it is tempting to consider the participation of the dopaminergic system as several studies have linked high dopamine levels with reduced mitochondrial capacity in cells (49,50). As we found activation of D1-containing cells following social competition, it is possible that differences in dopamine, as a function of anxiety, could contribute to the observed differences in mitochondrial function.…”

Section: Discussionmentioning

confidence: 78%

Mitochondrial function in the brain links anxiety with social subordination

Hollis

Kooij

Zanoletti

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

237

257

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Dominance hierarchies are integral aspects of social groups, yet whether personality traits may predispose individuals to a particular rank remains unclear. Here we show that trait anxiety directly influences social dominance in male outbred rats and identify an important mediating role for mitochondrial function in the nucleus accumbens. High-anxious animals that are prone to become subordinate during a social encounter with a low-anxious rat exhibit reduced mitochondrial complex I and II proteins and respiratory capacity as well as decreased ATP and increased ROS production in the nucleus accumbens. A causal link for these findings is indicated by pharmacological approaches. In a dyadic contest between anxietymatched animals, microinfusion of specific mitochondrial complex I or II inhibitors into the nucleus accumbens reduced social rank, mimicking the low probability to become dominant observed in highanxious animals. Conversely, intraaccumbal infusion of nicotinamide, an amide form of vitamin B3 known to enhance brain energy metabolism, prevented the development of a subordinate status in high-anxious individuals. We conclude that mitochondrial function in the nucleus accumbens is crucial for social hierarchy establishment and is critically involved in the low social competitiveness associated with high anxiety. Our findings highlight a key role for brain energy metabolism in social behavior and point to mitochondrial function in the nucleus accumbens as a potential marker and avenue of treatment for anxiety-related social disorders.anxiety | mitochondria | nucleus accumbens | social dominance | social competition

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“…Such mechanisms that can generate free radicals inside the body are represented by: the activation of neutrophils, the electron transport chain at the mitochondrial level, arachidonic acid metabolism, oxide-reduction of xanthine [28] or nitric oxide synthesis [27,[29][30][31]. The respiratory chain [32][33][34] has a key role at the cellular level, being responsible for the conversion of oxygen in water molecules. At the neutrophils' level, the major source of oxygen is the enzymatic complex NAD(P) H oxidase.…”

Section: Biochemical Aspects Of Free Radicals and The Actions Of Oxidmentioning

confidence: 99%

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

Bedreag¹,

Rogobete

Sărăndan³

et al. 2015

Anaesthesiol Intensive Ther

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Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.

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Perturbation in Mitochondrial Network Dynamics and in Complex I Dependent Cellular Respiration in Schizophrenia

Cited by 127 publications

References 79 publications

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood–brain barrier

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood–brain barrier

Mitochondrial function in the brain links anxiety with social subordination

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

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