Pertussis in Young Infants Throughout the World

Cherry, James D.

doi:10.1093/cid/ciw550

Cited by 79 publications

(63 citation statements)

References 28 publications

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“…Coughing episodes may cause brief periods of harmless apnea. Fever is not typically seen with pertussis infections, but gasping, gagging, and cyanosis are common [6]. While this patient did present with a similar paroxysmal cough, including apnea and gasping, fever was also present intermittently, setting it apart from a typical pertussis clinical vignette.…”

Section: Discussionmentioning

confidence: 65%

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Human Metapneumovirus causing Pertussis-like Syndrome

Sahhar¹,

Barcroft²,

Farber³

2017

Clin Pediatr OA

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Human metapneumovirus (hMPV), a common cause of respiratory illness in children, typically presents with clinical symptoms resembling that of respiratory syncytial virus. The unusual aspect in this case is the presentation of pertussis-like syndrome due to sole hMPV infection. To our knowledge, a case of pertussis-like syndrome caused by hMPV without concomitant Bordetella pertussis infection has not been reported.

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Section: Discussionmentioning

confidence: 65%

“…Typically, this virus is spread by direct contact or close contact with secretions [6,7]. Animal models with hMPV have shown a similar pathogenic process to RSV, demonstrating viral replication in the upper respiratory tracts and prolonged airway inflammation with a continuously detectable viral RNA load.…”

Section: Discussionmentioning

confidence: 99%

Human Metapneumovirus causing Pertussis-like Syndrome

Sahhar¹,

Barcroft²,

Farber³

2017

Clin Pediatr OA

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“…Because IgG antibodies can cross the placenta, almost all IgG antibodies present in infants 6 months old and younger arise from the mother. A set of studies showed that when acellular pertussis vaccine was given to pregnant women in the second or third trimester, especially at 27-36 weeks of pregnancy, enough antibodies against Bacillus pertussis, such as the anti-pertussis toxin and anti-lament hemagglutinin antibodies, were detected in the blood of the neonates, and the antibodies persisted and gradually declined until completely attenuated at the age of 3 months [6,7,8]. Therefore, acellular pertussis vaccine for pregnant women could protect infants from pertussis infections before the standard age of pertussis vaccination (the age of 3 months).…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical characteristics of pertussis in 184 infants and children: a retrospective study

Wang

Zhang

et al. 2020

Preprint

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Backgroud: The incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding of the clinical characteristics and risk factors for severe pertussis, and more effective measures should be taken to reduce the incidence and mortality of pertussis in young infants. Methods: A retrospective study was conducted, and 184 infants and children with pertussis who had been hospitalized in the Department of Pediatrics of Beijing Ditan Hospital affiliated with Capital Medical University from January 2016 to December 2017 were included in the study. Clinical data of the patients were collected and the clinical characteristics were statistically analyzed. Results: Among the 184 patients, 41.85% were infants < 3 months of age, and 65.22% were not vaccinated against pertussis. There were 22 critically ill children, among whom 4 died, and compared with moderate cases, they had a higher proportion of children younger than 3 months of age and infants not vaccinated against pertussis (63.64% vs. 38.89% and 100% vs. 60.49%, respectively); a higher proportion of children with pulmonary consolidation (77.27% vs. 1.85%); higher leukocyte count(× 109/L , 35.80 ± 20.53 vs 19.41 ± 8.59); and a higher proportion of children with severe hyperleukocytosis (18.18% vs. 0%, respectively) (P<0.05). Conclusions: 1. Infants aged < 3 months who were not vaccinated for pertussis tended to be infected with pertussis and had severe pertussis. Adjusting the immunization strategy to vaccinate pregnant women to produce protective effects for the infants should be considered. 2. Severe pneumonia and hyperleukocytosis are the main mechanisms underlying severe pertussis and the key points of prevention and diagnosis of severe pertussis.

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“…Çalışmamızda hastaların %22,2'sinde (n=4) ateş vardı, bu hastaların 3'ünde viral enfeksiyon eşlik ediyordu. Ateş görülme sıklığı dizin ile benzerlik göstermekteydi (17,18).…”

Section: Introductionunclassified

The clinical characteristics and prognosis of pertussis among unvaccinated infants in pediatric intensive care unit

2020

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Yoğun bakımda boğmaca tanısı ile izlenen aşısız süt çocuklarının klinik özellikleri ve seyri etkileyen etmenlerThe clinical characteristics and prognosis of pertussis among unvaccinated infants in pediatric intensive care unit Öz Amaç: Çocuk yoğun bakım biriminde boğmaca tanısıyla izlenen hastaların klinik özelliklerini, risk etmenlerini ve seyri etkileyen etmenleri değerlendirmeyi amaçladık. Gereç ve Yöntemler:Çocuk yoğun bakım birimimizde Ocak 2017-Ocak 2019 tarihleri arasında yatan ve boğmaca tanısı alan hastalar geriye dönük olarak değerlendirildi. Örnekler entübe olarak izlenen hastalarda trakeal aspirat materyalinden, diğer hastalarda nazofaringeal sürüntüden alındı. Bordetella pertussis için örnekler multiplex real-time polimeraz zincir reaksiyonu yöntemi ile çalışıldı. Bulgular:On sekiz hasta boğmaca tanısı ile çocuk yoğun bakım birimimize yatırıldı. Hastaların %55,5'i kızdı (n=10), tüm hastalar aşısızdı. Ortanca yaş 40 (38-47,5) gün, ortanca yoğun bakım yatış süresi 9 (5-14) gündü. Başvuru anında hastaların tümünde solunum sıkıntısı, 14 hastada (%77,7) öksürük, 4 hastada (%22.2) ateş, 3 hastada (%16,6) konvülziyon saptandı. Yedi hasta entübe edilerek izlendi. Üç hasta ekstrakorporeal tedavi yöntemleri uygulanmasına rağmen çoklu organ yetersizliği ve kardiyojenik şok nedeniyle kaybedildi. Ölen hastaların ikisinde respiratuar sinsityal virüs, birinde rhinovirüs ko-enfeksiyonu vardı. Toplam lökosit sayıları karşılaştırıldığında ölen hasta grubunda lökosit sayısı Abstract Aim: To evaluate the clinical characteristics, risk factors, and prognosis of pertussis in the pediatric intensive care unit. Material and Methods:Patients who were hospitalized in pediatric intensive care unit between January 2017 and January 2019 and diagnosed as having pertussis were retrospectively evaluated. Samples were taken from tracheal aspirate material in intubated patients and nasopharyngeal swabs in the other patients. Samples for Bordetella pertussis were studied using multiplex real-time polymerase chain reaction.Results: Eighteen patients were admitted to our pediatric intensive care unit with a diagnosis of pertussis. Ten patients were female (55.5%), and all patients were unvaccinated. The median age was 40 (range, 38-47.5) days and the median intensive care unit stay was 9 (range, 5-14) days. All patients had respiratory distress, 14 patients had cough (77.7%), four patients had fever (22.2%), and three patients had convulsions (16.6%). Seven patients were intubated. Three patients died of multiple organ failure and cardiogenic shock despite extracorporeal treatment. Respiratory syncytial virus was found in two patients and rhinovirus was found in one patient. The median leukocyte count was significantly higher in non-survivors than in survivors. Blood exchange was performed in Boğmaca aşı ile önlenebilir bir hastalıktır. Etkeni Bordetella Pertussis'tir, süt çocuklarında sıklıkla pnömoniye yol açar. Aşısız süt çocuklarında ciddi hastalık tablosu oluşturabilir. Çalışmanın katkısıYoğun bakıma kabul edilen hastalarda ciddi b...

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Pertussis in Young Infants Throughout the World

Cited by 79 publications

References 28 publications

Human Metapneumovirus causing Pertussis-like Syndrome

Human Metapneumovirus causing Pertussis-like Syndrome

Analysis of clinical characteristics of pertussis in 184 infants and children: a retrospective study

The clinical characteristics and prognosis of pertussis among unvaccinated infants in pediatric intensive care unit

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