Peste des petits ruminants pathogenesis on experimental infected goats by the Moroccan 2015 isolate

Bamouh, Zahra; Fakri, F.; Jazouli, Mohammed; Safini, Najete; Tadlaoui, Khalid Omari; Elharrak, Mehdi

doi:10.1186/s12917-019-2164-6

Cited by 23 publications

(21 citation statements)

References 31 publications

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“…Also, passages in cell cultures can affect the degree of pathogenicity of an isolate [ 21 ]. Upon infection, PPRV can be found in both lymphoid tissue (spleen, tonsil, mesenteric, sub-maxillary, bronchial, retropharyngeal and pulmonary lymph nodes) and non-lymphoid tissue (nostrils, trachea, abomasum, jejunum, ileum, cecum, lung, intestine, liver, kidney and heart) [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence

Eloiflin

Grau‐Roma

Python

et al. 2022

Vet Res

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Peste des petits ruminants (PPR) is an acute disease of small ruminants caused by a morbillivirus. Clinical observation of the disease in the field revealed that several species of small ruminants are affected to varying degrees. This difference in disease-related effects could depend either on the host or on the virulence of the virus strain. A previous study highlighted the difference in virulence between two strains of PPRV used to infect Saanen goats. For this breed, PPRV Morocco 2008 strain (MA08) was highly virulent while PPRV Côte d’Ivoire 1989 (IC89) strain induced mild disease. Experimental studies generally based on healthy and young animals do not permit exploration of the natural variability of the host susceptibility to PPRV. Therefore, building on the previous study on Saanen goats, the current study focussed on this breed of goat and used commercially available animals with an unknown history of infection with other pathogens. Results confirmed the previous disease pattern for PPRV IC89 and MA08 strains. Viral RNA detection, macroscopic and histological lesions were stronger for the highly virulent MA08 strain. We show here for the first time that viral RNA can be detected in the tissues of vaccinated animals. Viral RNA was also detected for the first time in serum samples, which is in agreement with the role of circulating immune cells in transporting the virus into host target organs. Thus, this study provides insight into the pathogenesis of strains of different virulence of PPRV and will help to better understand the onset of the disease.

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Section: Introductionmentioning

confidence: 99%

Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence

Eloiflin

Grau‐Roma

Python

et al. 2022

Vet Res

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“…The morbidity rate may reach 100% with a high mortality rate during acute illness [ 4 , 5 ]. The afore-mentioned clinical signs and mortality may vary significantly depending on the virulence of the viral strain and the immunological state of the affected animal [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Field serological investigation for peste des petits ruminants, foot-and-mouth disease, and bluetongue diseases in illegally introduced animals in Egypt

Hosny¹,

Baheeg²,

Aly³

et al. 2020

Vet World

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Aim: In this study, laboratory scoping on the viruses that cause peste des petits ruminants (PPR), bluetongue (BT), and foot-and-mouth disease (FMD) was performed to evaluate the current status of animals illegally introduced into Egypt. This study aims to help control these infectious illnesses and tries to prevent the introduction of other strains of these three viruses to Egypt, as these illnesses spread quickly if not controlled. Materials and Methods: In the year 2018, 62 serum samples were collected and serologically tested through competitive enzyme-linked immunosorbent assays (ELISA) kits to detect antibodies against PPR, BT, and FMD, which are three important transboundary infectious illnesses. Results: The results indicated that 60 out of 62 serum samples were positive for PPR antibodies (96.7%), 31 out of 62 were positive for FMD antibodies (50%), and 59 out of 62 serum samples were positive for BT antibodies (95%). Conclusion: This study revealed that PPR, FMD, and BT can be introduced into Egypt through the illegal introduction of sheep and goat from neighboring countries. Laboratory diagnostic abilities should be improved for the early detection and control of these illnesses.

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“…An in-silico approach to protein analysis may help with development of vaccines and therapeutics [527]. Experimental infections of goats and sheep have been described and are suitable for comparative studies and vaccine evaluation [528][529][530]. Mice, rabbits, and horses have also played a role in diagnosis, treatment, and vaccine development [531][532][533].…”

Section: Peste Des Petits Ruminantsmentioning

confidence: 99%

Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

Clemmons

Alfson

Dutton

2021

Animals

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Animals provide food and other critical resources to most of the global population. As such, diseases of animals can cause dire consequences, especially disease with high rates of morbidity or mortality. Transboundary animal diseases (TADs) are highly contagious or transmissible, epidemic diseases, with the potential to spread rapidly across the globe and the potential to cause substantial socioeconomic and public health consequences. Transboundary animal diseases can threaten the global food supply, reduce the availability of non-food animal products, or cause the loss of human productivity or life. Further, TADs result in socioeconomic consequences from costs of control or preventative measures, and from trade restrictions. A greater understanding of the transmission, spread, and pathogenesis of these diseases is required. Further work is also needed to improve the efficacy and cost of both diagnostics and vaccines. This review aims to give a broad overview of 17 TADs, providing researchers and veterinarians with a current, succinct resource of salient details regarding these significant diseases. For each disease, we provide a synopsis of the disease and its status, species and geographic areas affected, a summary of in vitro or in vivo research models, and when available, information regarding prevention or treatment.

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Peste des petits ruminants pathogenesis on experimental infected goats by the Moroccan 2015 isolate

Cited by 23 publications

References 31 publications

Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence

Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence

Field serological investigation for peste des petits ruminants, foot-and-mouth disease, and bluetongue diseases in illegally introduced animals in Egypt

Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

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