Pesticide residues in human breast milk: Risk assessment for infants from Punjab, India

Bedi, Jasbir Singh; Gill, Jatinder Paul Singh; Aulakh, Rabinder Singh; Kaur, P.; Sharma, Anupama; Pooni, Puneet A

doi:10.1016/j.scitotenv.2013.06.066

Cited by 76 publications

(42 citation statements)

References 44 publications

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“…The results implied no fresh input of endosulfan to the sampling areas recently. Technical DDTs has been banned in China since 1983, but is still applied against mosquitoes in several countries, such as India, to control malaria (Bedi et al, 2013). Application of technical DDT and DDT-containing dicofol may be responsible for the DDTs occurrence in the environment.…”

Section: Potential Sources Of Popsmentioning

confidence: 99%

Environmental fate and behavior of persistent organic pollutants in Shergyla Mountain, southeast of the Tibetan Plateau of China

Zhu

Schramm

Wang

et al. 2014

Environmental Pollution

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a b s t r a c tPristine mountains are ideal settings to study transport and behavior of persistent organic pollutants (POPs) along gradients of climate and land cover. The present work investigated the concentrations and patterns of 28 organochlorine pesticides (OCPs), 25 polychlorinated biphenyl (PCBs), 13 polybrominated diphenyl ethers (PBDEs), and 3 hexabromocyclododecane (HBCDs) isomers in the air of the Shergyla Mountain, southeastern Tibetan Plateau. Endosulfan _, hexachlorobenzene, pentachlorobenzene, hexachlorocyclohexanes and dichlorodibenzotrichloroethane and its degradation products (DDTs) were the predominant compounds while PBDEs and HBCDs showed the lowest background concentrations. Most of the target POPs had significantly higher concentrations in summer than those in winter. Increasing trends of the concentrations of DDTs and endosulfan were found with increasing altitude on the western slope in the Shergyla Mountain. Potential forest filter effect was observed based on the lower air concentrations of the target POPs in the forest than the ones out of the forest.

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Section: Potential Sources Of Popsmentioning

confidence: 99%

Environmental fate and behavior of persistent organic pollutants in Shergyla Mountain, southeast of the Tibetan Plateau of China

Zhu

Schramm

Wang

et al. 2014

Environmental Pollution

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“…The p,p′-DDE/p,p′-DDT ratio ranged from 1 to 23, where 58% of the mothers had a ratio below 5 indicating recent or ongoing DDT exposure. Analysis of pesticide residues in human breast milk samples collected from Punjab state in India by Bedi et al [27] revealed the presence of β-, γ-HCH, p,p' DDD, p,p' DDE, p,p' DDT and ending with mean concentration of 97.9, 101.7, 239.8, 1574.1, 100.3 and 90.7 ng/g milk lipid, respectively. With increase in parity, HCH and DDT residue burden in donor's milk decreased.…”

Section: Organochlorine Pesticides (Ocps)mentioning

confidence: 99%

“…However, the median level of chlorpyrifos in agricultural women was 28 pg/g milk lipid. Japan 341 µg/g milk lipid, Nagayama et al [16] β-HCH USA 220-443 pg/g milk lipid, Weldon et al [25] UK 0.050 µg/g milk lipid, Harris et al [14] Germany 0.0116 µg/g milk lipid, Zietz et al [21] India 97.9 ng/g milk lipid, Bedi et al [27] γ -HCH India 101.7 ng/g milk lipid, Bedi et al [27] UK 0.025 µg/g milk lipid, Harris et al [14] Australia 80 ng/g lipid, Mueller et al [22] Chlordane Japan 69 µg/g milk lipid, Nagayama et al [16] Transnonachlor Australia 11 ng/g lipid, Mueller et al [22] On the other hand, many investigators have been studied the lactational transfer of organophosphorus compounds in animal as a model. Bakry et al [37] studied the milk transfer of phosfolan and mephosfolan in mice.…”

Section: Organophosphorus Pesticidesmentioning

confidence: 99%

“…Chlorpyrifos India 24.5-28.0 pg/g milk lipid in urban women, Weldon et al [25] 1.91 ng/g milk, Bedi et al [27], 4.003 ng/g milk lipid, Srivastava et al [34] Chlorpyrifos-methyl USA 4.02 pg/g milk lipid in urban women, Weldon et al [25] Ethion India 48.000 ng/g milk lipid, Srivastava et al [34] Dimethoate India 85.888 ng/g milk lipid, Srivastava et al [34] Sri Lanka >50 µg/l milk, Samarawickrema et al [36] Profenophos India 2.66 ng/g milk, Bedi et al [27] Monocrotophos India 1.63 ng/g milk, Bedi et al [27] Phosalone India 0.29 ng/g milk, Bedi et al [27] …”

Section: Country Amounts and Referencementioning

confidence: 99%

“…The median concentration value of total pyrethroids ranged between 87 and 1200 ng/g milk lipid, with λ-cyhalothrin being the most predominant pyrethroid in human breast milk contributing for 35% of the total amount. The study from India, Bedi et al [27] revealed that the presence of cypermethrin in human breast milk. Recently, Sharma et al [35] conducted very similar study in same region, Punjab, India.…”

Section: Synthetic Pyrethroidsmentioning

confidence: 99%

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Lactational Exposure to Pesticides: A Review

Salama¹

2017

Toxicol Open Access

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The aim of this study is to review the reports of pesticides have been detected in human breast milk in worldwide. Contamination levels of pesticides such as organochlorine pesticides (OCPs), organophosphorus pesticides (OPPs), carbamates and pyrethroids in human breast milk were found to be varied in different countries. The chemical properties of chemicals such as lack of ionization, small molecular weight, low volume of distribution, low maternal serum protein binding, and high lipid solubility, facilitate compound excretion into human milk. Since exposure to pesticides during the early postnatal stages may disturb the normal development of the newborn, such studies may shed light on the wide variety of pesticides that have been detected in human breast milk.

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Early embryonic exposure to chlorpyrifos‐cypermethrin combination induces pattern deficits in the heart of domestic hen

Verma

Khaire

Desai

et al. 2020

Environmental Toxicology

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Exposure to chlorpyrifos‐cypermethrin combination during early development resulted in defective looping and ventricular noncompaction of heart in domestic chicken. The study was extended to elucidate the molecular basis of this novel observation. The primary culture of chicken embryonic heart cells showed a concentration‐dependent loss of viability when challenged with this combination of technical‐grade insecticides. Comet assay, DNA ladder assay, and analyses of appropriate markers at transcript and protein levels, revealed that chlorpyrifos‐cypermethrin combination induced cell death by activating apoptosis. Parallelly, the tissues derived from control and experimental group hearts were checked for apoptotic markers, and the result was much similar to that of the in‐vitro study. Further analysis showed that chlorpyrifos‐cypermethrin combination deranged the expression pattern of the transcriptional regulators of cardiogenesis, namely TBX20, GATA5, HAND2, and MYOCD. This, together with heightened apoptosis, could well be the reason behind the observed structural anomalies in the heart of chlorpyrifos‐cypermethrin poisoned embryos.

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Pesticide residues in human breast milk: Risk assessment for infants from Punjab, India

Cited by 76 publications

References 44 publications

Environmental fate and behavior of persistent organic pollutants in Shergyla Mountain, southeast of the Tibetan Plateau of China

Environmental fate and behavior of persistent organic pollutants in Shergyla Mountain, southeast of the Tibetan Plateau of China

Lactational Exposure to Pesticides: A Review

Early embryonic exposure to chlorpyrifos‐cypermethrin combination induces pattern deficits in the heart of domestic hen

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