PET – advanced nuclear imaging technology for medicine

Piwowarska-Bilska, Hanna; Supińska, Aleksandra; Iwanowski, Jacek; Tyczyńska, Adriana; Birkenfeld, Bożena

doi:10.21164/pomjlifesci.609

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The identification of psychiatric disease entities and their relationship with organic diseases from other medical specialties (e.g., epilepsy and Parkinson's disease) as well as monitoring the treatment with synthetic drugs and potentially biologically active substances of plant origin can be completed with classical patient examination, electroencephalography, laboratory tests of biological samples, and population studies (including surveys). Special techniques currently include various ways of neuroimaging, mainly functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), which provide information about morphological changes and functional disorders occurring in depression or characteristics of diseases accompanied by depression [144][145][146][147][148][149][150][151][152][153][154].…”

Section: Neurotransmitters As the Key Pathogenetic Factorsmentioning

confidence: 99%

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

et al. 2019

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Herbal therapy is a potential alternative applied to pharmacological alleviation of depression symptoms and treatment of this disorder, which is predicted by the World Health Organization (WHO) to be the most serious health problem worldwide over the next several years. It has been well documented that many herbs with psychotropic effects have far fewer side effects than a variety of pharmaceutical agents used by psychiatrists for the treatment of depression. This systematic review presents literature data on the antidepressant activity of representatives of the genera Hemerocallis (H. fulva and H. citrina Baroni, family Xanthorrhoeaceae) and Gladiolus (G. dalenii, family Iridaceae) and on biologically active compounds and their mechanisms of action to consider the application of herbal preparations supporting the treatment of depression.

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Section: Neurotransmitters As the Key Pathogenetic Factorsmentioning

confidence: 99%

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

et al. 2019

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Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury

Pringle,

Ramon-Gil,

Leslie

et al. 2024

Sci Rep

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Synaptophysin is expressed on fibrogenic hepatic myofibroblasts. C1–3 is a single chain human antibody (scAb) that binds specifically to synaptophysin on hepatic myofibroblasts, providing a targeting vector for novel in vivo imaging agents of chronic liver disease. C1–3 and a negative control scAb, CSBD9, were radiolabelled with zirconium-89 via desferrioxamine chelation to enable non-invasive molecular imaging with positron emission tomography (PET). DFO-scAb conjugates were characterised by gel electrophoresis (SDS-PAGE) and MALDI-TOF spectrometry, and 89Zr-labelled with high radiolabelling efficiency (99%). [89Zr]Zr-DFO-C1–3 exhibited high in vitro stability (> 99%) in mouse and human sera over 3 days at 25 and 37 °C. Activated hepatic myofibroblasts incubated with [89Zr]Zr-DFO-C1–3 displayed significantly higher internalised activity (59.46%, P = 0.001) compared to the [89Zr]Zr-DFO-CSBD9 control, indicating synaptophysin-mediated uptake and high binding specificity of [89Zr]Zr-DFO-C1–3. Mice with CCl4-induced acute liver damage exhibited significantly higher liver uptake of [89Zr]Zr-DFO-C1–3, compared to controls, confirmed by both Cerenkov imaging and ex vivo gamma counting (4.41 ± 0.19%ID/g, P < 0.0001). CCl4-induced liver damage and the number of hepatic myofibroblasts was confirmed by αSMA staining of liver sections. These findings indicate that [89Zr]Zr-DFO-C1–3 has promising utility as a PET imaging agent for non-invasive detection of hepatic myofibroblasts following acute liver injury.

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Residual Pix2Pix networks: streamlining PET/CT imaging process by eliminating CT energy conversion

Ghanbari,

Sadremomtaz

2024

Biomed. Phys. Eng. Express

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ObjectiveAttenuation correction of PET data is commonly conducted through the utilization of a secondary imaging technique to produce attenuation maps. The customary approach to attenuation correction, which entails the employment of CT images, necessitates energy conversion. However, the present study introduces a novel deep learning-based method that obviates the requirement for CT images and energy conversion.MethodsThis study employs a residual Pix2Pix network to generate attenuation-corrected PET images using the 4033 2D PET images of 37 healthy adult brains for train and test. The model, implemented in TensorFlow and Keras, was evaluated by comparing image similarity, intensity correlation, and distribution against CT-AC images using metrics such as PSNR and SSIM for image similarity, while a 2D histogram plotted pixel intensities. Differences in standardized uptake values (SUV) demonstrated the model's efficiency compared to the CTAC method.ResultsThe residual Pix2Pix demonstrated strong agreement with the CT-based attenuation correction, the proposed network yielding MAE, MSE, PSNR, and MS-SSIM values of 3×10-3, 2×10-4, 38.859, and 0.99, respectively. The residual Pix2Pix model's results showed a negligible mean SUV difference of 8×10-4(P-value = 0.10), indicating its accuracy in PET image correction. The residual Pix2Pix model exhibits high precision with a strong correlation coefficient of R2 = 0.99 to CT-based methods. The findings indicate that this approach surpasses the conventional method in terms of precision and efficacy.ConclusionsThe proposed residual Pix2Pix framework enables accurate and feasible attenuation correction of brain F-FDG PET without CT. However, clinical trials are required to evaluate its clinical performance. The PET images reconstructed by the framework have low errors compared to the accepted test reliability of PET/CT, indicating high quantitative similarity.

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PET – advanced nuclear imaging technology for medicine

Cited by 3 publications

References 7 publications

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury

Residual Pix2Pix networks: streamlining PET/CT imaging process by eliminating CT energy conversion

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