2016
DOI: 10.1007/s00381-016-3125-z
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PET and SPECT studies in children with hemispheric low-grade gliomas

Abstract: Molecular imaging is playing an increasing role in the pre-treatment evaluation of low-grade gliomas. While glucose positron emission tomography (PET) can be helpful to differentiate low-grade from high-grade tumors, PET imaging with amino acid radiotracers has several advantages, such as better differentiation between tumors and non-tumorous lesions, optimized biopsy targeting and improved detection of tumor recurrence. This review provides a brief overview of single photon emission computed tomography (SPECT… Show more

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Cited by 5 publications
(5 citation statements)
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“…[ 27 29 ] A number of amino acid PET radiotracers were helpful in pretreatment evaluation of pediatric low-grade gliomas. [ 30 ] The second one is optical molecular imaging, in which a fluorescent probe is used to provide real-time imaging of distribution and kinetics. Although high spatial resolution could be obtained inexpensively, the imaging region is limited to the body surface.…”
Section: Discussionmentioning
confidence: 99%
“…[ 27 29 ] A number of amino acid PET radiotracers were helpful in pretreatment evaluation of pediatric low-grade gliomas. [ 30 ] The second one is optical molecular imaging, in which a fluorescent probe is used to provide real-time imaging of distribution and kinetics. Although high spatial resolution could be obtained inexpensively, the imaging region is limited to the body surface.…”
Section: Discussionmentioning
confidence: 99%
“…Compared to PET, SPECT is much more available, cheaper, and widely used. However, SPECT typically needs a longer scan time, has a lower resolution, and is prone to artifacts and attenuation [ 208 , 209 , 210 ]. It has been mainly used to estimate perfusion and cerebral blood flow, and studies in pediatric brain tumors have been relatively scarce.…”
Section: Single-photon Emission Computed Tomography (Spect) Investiga...mentioning
confidence: 99%
“…Their uptake in tumor cells reflect the level of amino-acid transport. Still, some low-grade tumors may show increased amino acid uptake due to augmented vascularity and/or upregulation of amino acid transporters at the BBB [ 46 ].…”
Section: Discussion/future Perspectivesmentioning
confidence: 99%