PET-Based Imaging with 18F-FDG and 18F-NaF to Assess Inflammation and Microcalcification in Atherosclerosis and Other Vascular and Thrombotic Disorders

Raynor, William; Park, Peter Sang Uk; Borja, Austin J; Sun, Yusha; Werner, Thomas; Ng, Sze Jia; Lau, Hui Chong; Høilund‐Carlsen, Poul Flemming; Alavi, Abass; Revheim, Mona‐Elisabeth

doi:10.3390/diagnostics11122234

Cited by 13 publications

(8 citation statements)

References 161 publications

(214 reference statements)

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“…This supports [ 18 F]NaF PET/CT as a promising noninvasive technique for identifying and locating ruptured and high-risk coronary atherosclerotic plaques ( 17 ). The most representative citing article in the atherosclerotic plaque cluster (36 cited articles) was a paper by Raynor et al This paper systematically summarizes the roles of NaF and fluorodeoxyglucose (FDG) in assessing the progression of atherosclerosis and suggests that NaF PET/CT has the potential to be a comprehensive detection method for the early evaluation of atherosclerosis ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

[18F]sodium fluoride positron emission tomography: a systematic bibliometric review from 2008 to 2022

Zhou,

Liu,

et al. 2023

Quant Imaging Med Surg

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Background As a noninvasive diagnostic tool, fluorine-18-labelled sodium fluoride positron emission tomography ([ 18 F]NaF PET) has been increasingly applied in clinical practice due to its excellent imaging performance, attracting more attention from clinical practitioners. However, with the continuous development of technology and growth of knowledge, the field of [ 18 F]NaF PET is changing. Nevertheless, few studies have conducted quantitative analyses of the literature in this field. Therefore, in this study, we used bibliometric methods to analyze the trends, content distribution, and frontiers of this field from multiple perspectives, including social and international structure, conceptual structure, and intellectual structure. Methods This study used the Web of Science (WOS) core database as the data source and retrieved literature related to [ 18 F]NaF PET between 2008 and 2022. CiteSpace and VOSviewer software were then employed for bibliometric analysis. This study performed co-occurrence analysis and citation analysis to investigate the characteristics of [ 18 F]NaF PET in 3 aspects. Results A total of 682 articles related to [ 18 F]NaF PET were collected during the period from 2008 to 2022. The author, Alavi, had the highest number of publications (67 articles). In terms of institutions, the University of Edinburgh had the highest number of publications (64 articles). The United States (300 articles) was the country with the highest number of published articles. Keyword co-occurrence analysis revealed that [ 18 F]NaF PET-related technologies, bone metastasis (prostate cancer and breast cancer), and atherosclerosis were prominent research directions in this field. In terms of highly cited authors, Even-Sapir had the highest citation count (188 citations). Regarding highly cited journals, the Journal of Nuclear Medicine ranked as the most highly cited journal. The literature co-citation clustering and timeline graph showed that atherosclerotic plaques, bone metastasis, and the clinical applications of [ 18 F]NaF PET were topics of active research in this field. Conclusions There has been an increase in the literature published in the field of [ 18 F]NaF PET from 2008 to 2022. The United States holds a prominent position in the field of [ 18 F]NaF PET. Arteriosclerosis and bone metastasis are the main topics in this field and at the forefront of research.

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Section: Discussionmentioning

confidence: 99%

[18F]sodium fluoride positron emission tomography: a systematic bibliometric review from 2008 to 2022

Zhou,

Liu,

et al. 2023

Quant Imaging Med Surg

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“…Among main limitation of the use of 18F-FDG PET for coronary arteries are cardiac and respiratory movements along with spatial resolution (3 × 3 × 3 mm voxel size) and insufficient myocardial suppression. Recently, these limitations were confirmed by the findinfg that 50% of coronary segments, especially the distal coronary bed, may not be interpreted using 18F-PD PET (84).…”

Section: Molecular Methods For Imaging Inflammationmentioning

confidence: 99%

Diagnostics of atherosclerosis: Overview of the existing methods

Poznyak

Sukhorukov

Еремин

et al. 2023

Front. Cardiovasc. Med.

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Atherosclerosis was and remains an extremely common and serious health problem. Since the elderly are most at risk of cardiovascular risk, and the average life expectancy is increasing, the spread of atherosclerosis and its consequences increases as well. One of the features of atherosclerosis is its asymptomaticity. This factor makes it difficult to make a timely diagnosis. This entails the lack of timely treatment and even prevention. To date, in the arsenal of physicians, there is only a limited set of methods to suspect and fully diagnose atherosclerosis. In this review, we have tried to briefly describe the most common and effective methods for diagnosing atherosclerosis.

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“…Expected physiologic uptake of FDG by the myocardium is much higher than the subtle changes in uptake resulting from plaque formation in the coronary arteries. Thus, given the limitations of FDG in this domain, it is expected that NaF-PET/CT will play a major role in PET-based atherosclerosis imaging [44,45].…”

Section: Vascular Inflammationmentioning

confidence: 99%

Emerging PET Tracers in Cardiac Molecular Imaging

Singh

Lau

et al. 2023

Cardiol Ther

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18F-fluorodeoxyglucose (FDG) and 18 F-sodium fluoride (NaF) represent emerging PET tracers used to assess atherosclerosis-related inflammation and molecular calcification, respectively. By localizing to sites with high glucose utilization, FDG has been used to assess myocardial viability for decades, and its role in evaluating cardiac sarcoidosis has come to represent a major application. In addition to determining late-stage changes such as loss of perfusion or viability, by targeting mechanisms present in atherosclerosis, PET-based techniques have the ability to characterize atherogenesis in the early stages to guide intervention. Although it was once thought that FDG would be a reliable indicator of ongoing plaque formation, micro-calcification as portrayed by NaF-PET/CT appears to be a superior method of monitoring disease progression. PET imaging with NaF has the additional advantage of being able to determine abnormal uptake due to coronary artery disease, which is obscured by physiologic myocardial activity on FDG-PET/CT. In this review, we discuss the evolving roles of FDG, NaF, and other PET tracers in cardiac molecular imaging.Shashi Bhushan Singh and Sze Jia Ng contributed equally to this work.

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PET-Based Imaging with 18F-FDG and 18F-NaF to Assess Inflammation and Microcalcification in Atherosclerosis and Other Vascular and Thrombotic Disorders

Cited by 13 publications

References 161 publications

[18F]sodium fluoride positron emission tomography: a systematic bibliometric review from 2008 to 2022

[18F]sodium fluoride positron emission tomography: a systematic bibliometric review from 2008 to 2022

Diagnostics of atherosclerosis: Overview of the existing methods

Emerging PET Tracers in Cardiac Molecular Imaging

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