PET/CT in Renal, Bladder, and Testicular Cancer

Bouchelouche, Kirsten; Choyke, Peter L.

doi:10.1007/978-3-030-39457-8_24

Cited by 1 publication

(2 citation statements)

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“…In this case, it is critical that an imaging modality distinguishes between viable and non-viable disease. FDG-PET being a functional imaging modality, is able to detect viable tumors in these residual masses [7]. A meta-analysis done by Corsi et al concluded that the use of PET-CT in the evaluation of post-chemotherapy residual masses in patients with seminoma-type testicular cancer could avoid a significant percentage of unnecessary surgeries [8].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of post-chemotherapy residual seminomatous masses by 18F-fluorodeoxyglucose PET/CT using tumor-to-liver ratio – conundrum or solution?

Ghosh,

Agrawal,

Rangarajan

et al. 2023

Nuclear Medicine Communications

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Objective Assessment of diagnostic accuracy of FDG-PET/CT in the detection of viable disease in post-chemotherapy seminomatous residual masses using visual interpretation, SUVmax, and T/L ratio. Methods This is a retrospective study assessing the post-chemotherapy seminomatous residual masses of size >3 cm. The PET/CT scan findings were interpreted visually for presence of residual disease which were validated from histopathology reports or imaging follow-up for a maximum of 3 years. SUVmax and T/L ratios were also determined for all the residual lesions. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value NPV were calculated and compared for all three parameters along with ROC analysis to obtain an optimal cutoff value for SUVmax and T/L ratio, respectively. Results Sample size was 49. Out of these 49 patients, 8 had validation of PET results with histopathology. Rest was validated with imaging follow-up. FDG-PET was positive in 30 patients and negative in 19 patients by visual interpretation. The sensitivity, specificity, PPV, and NPV by this method were 100%, 62.5%, 73%, and 100%, respectively. The SUVmax and T/L ratios were also calculated for these lesions. The cutoff for these two variables was 4.56 and 1.21, respectively. The sensitivity, specificity, PPV, and NPV at these cutoffs were 76%, 87.5%, 86%, 77.7%, and 92%, 87.5%, 88%, 91%, respectively. Conclusion FDG-PET has a favorable diagnostic value in predicting viable disease in post-chemotherapy seminomatous residual masses and using T/L ratio cutoff of 1.21 will increase the specificity of the test.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%