PET Imaging for Endocrine Malignancies: From Woe to Go

Abstract

Over the past decade, there have been significant advances in endocrine tumor imaging using various radiopharmaceuticals. For many years, planar imaging and SPECT with 131 I and 123 I, 99m 111 In-pentetreotide, and 123/131 I-metaiodobenzylguanidine were the only scintigraphic techniques available for imaging specific tumor types, but their diagnostic performance was inconsistent across the myriad of endocrine-related cancers. Recently, new PET agents have been introduced into clinical practice to enhance the sensitivity and specificity of nuclear imaging of these conditions. These agents provide an endocrine tumor-specific characterization that now also includes characterization of specific metabolic pathways that might be targeted for their treatment. Information provided by PET/CT is widely dependent on tumor type.Endocrine tumors are broadly categorized into 3 groups ( Fig.

Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging

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Exploiting induced senescence in intestinal organoids to drive enteroendocrine cell expansion

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