PET/NIRF/MRI triple functional iron oxide nanoparticles

Xie, Jin; Chen, Kai; Huang, Jing; Lee, Seulki; Wang, Jinhua; Gao, Jinhao; Li, Xingguo; Chen, Xiaoyuan

doi:10.1016/j.biomaterials.2010.01.010

Cited by 461 publications

(335 citation statements)

References 36 publications

Supporting

Mentioning

328

Contrasting

Unclassified

Order By: Relevance

“…Several groups have focused on the development of radiolabeled nanoprobes for the detection of this disease. Passive accumulation of nanoradiotracers in tumors, due to enhanced permeability and retention (EPR) effect, has been widely used as a delivery strategy to locate carcinogenic tissue [6,107,108]. EPR effect is the increased permeation of blood vessels to tumor interstitial space, surrounding tumor environments.…”

Section: Iron Oxide Nanoparticles (Ionps)mentioning

confidence: 99%

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

et al. 2018

View full text Add to dashboard Cite

Abstract:The combination of radioisotopes and nanomaterials is creating a new library of tracers for molecular imaging, exploiting the sensitivity of nuclear imaging techniques and the size-dependent properties of nanomaterials. This new approach is expanding the range of applications, including the possibility of theranostics. Among the many different combinations, the use of 68 Ga as the radioisotope in the radio-nanomaterial is particularly convenient. The physicochemical properties of this isotope allow incorporating it into many materials with great chemical flexibility. Furthermore, its production from a benchtop generator eases the preparation of the tracer. Here, we review main results from the last years in which a nanomaterial has been radiolabeled with 68 Ga. In thus process, we pay attention to the use of nanomaterials for biomedical imaging in general and main properties of this radioisotope. We study the main methods to carry out such radiolabeling and the most important applications for molecular imaging.

show abstract

Section: Iron Oxide Nanoparticles (Ionps)mentioning

confidence: 99%

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Among the other modalities that have been combined with PET, it should be mentioned that ultrasmall cancerselective silica particles grafted with iodine and dyedoped polymers were recently approved by the FDA for in-human clinical trials [203] , NIRF agents within the silica NPs [204] or QDs [168,205,206] , and MRI [199] agents in conjunction with iron oxide nanomaterials [35,171] . A bifunctional chelator [dithiocarbamate bisphosphonate (dtcbp)], containing a dithiocarbamate group for binding the PET isotope 64 Cu and a bisphosphonate group for strong binding to Fe 3 O 4 , was elaborated .…”

Section: Coupling With Other Contrast Agentsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

View full text Add to dashboard Cite

Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

show abstract

“…[37][38][39] Therefore, the surface properties such as surface functional composition and zeta potential, of the nanoparticles are retained.…”

Section: Nir Fluorescent Io-hsa Nanoparticlesmentioning

confidence: 99%

Design of near-infrared fluorescent bioactive conjugated functional iron oxide nanoparticles for optical detection of colon cancer

Corem-Salkmon¹,

Perlstein²,

Margel³

2012

IJN

View full text Add to dashboard Cite

Background: Colon cancer is one of the major causes of death in the Western world. Early detection significantly improves long-term survival for patients with the disease. Near-infrared (NIR) fluorescent nanoparticles hold great promise as contrast agents for tumor detection. NIR offers several advantages for bioimaging compared with fluorescence in the visible spectrum, ie, lower autofluorescence of biological tissues, lower absorbance, and consequently deeper penetration into biomatrices. Methods and results: NIR fluorescent iron oxide nanoparticles with a narrow size distribution were prepared by nucleation, followed by controlled growth of thin iron oxide films onto cyanine NIR dye conjugated gelatin-iron oxide nuclei. For functionalization, and in order to increase the NIR fluorescence intensity, the NIR fluorescent iron oxide nanoparticles obtained were coated with human serum albumin containing cyanine NIR dye. Leakage of the NIR dye from these nanoparticles into phosphate-buffered saline solution containing 4% albumin was not detected. The work presented here is a feasibility study to test the suitability of iron oxide-human serum albumin NIR fluorescent nanoparticles for optical detection of colon cancer. It demonstrates that encapsulation of NIR fluorescent dye within these nanoparticles significantly reduces photobleaching of the dye. Tumor-targeting ligands, peanut agglutinin and anticarcinoembryonic antigen antibodies (αCEA), were covalently conjugated with the NIR fluorescent iron oxidehuman serum albumin nanoparticles via a poly(ethylene glycol) spacer. Specific colon tumor detection was demonstrated in chicken embryo and mouse models for both nonconjugated and the peanut agglutinin-conjugated or αCEA-conjugated NIR fluorescent iron oxide-human serum albumin nanoparticles. Conclusion: Conjugation of peanut agglutinin or αCEA to the nanoparticles significantly increased the fluorescence intensity of the tagged colon tumor tissues relative to the nonconjugated nanoparticles.

show abstract

PET/NIRF/MRI triple functional iron oxide nanoparticles

Cited by 461 publications

References 36 publications

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Design of near-infrared fluorescent bioactive conjugated functional iron oxide nanoparticles for optical detection of colon cancer

Contact Info

Product

Resources

About