Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity

Choi, Yang-Ho; Lee, Kyoung‐Pil; Kim, Jungmin; Kang, Su-Tae; Park, Soo‐Jin; Lee, Jungmin; Moon, Hyung Ryong; Jung, Jee H.; Lee, Young‐Geun; Im, Dong‐Soon

doi:10.1016/j.jep.2015.12.010

Cited by 22 publications

(12 citation statements)

References 27 publications

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“…3A ). Degrees of lung inflammation were also semi-quantitatively analyzed using a subjective scale of 0–3, as previously described ( Tournoy et al ., 2000 ; Kwak et al ., 2003 ; Choi et al ., 2016 ). The inflammation score in the OVA-treated group was nearly 3 and treatment with oroxylin A was found to reduce the inflammation score in a dose-dependent manner ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments

Lee

Kang

Park

et al. 2016

Biomol Ther (Seoul)

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Oroxylum indicum has long been used in Asian traditional medicine to prevent and treat respiratory diseases, diabetes, diarrhea and other conditions. Oroxylin A is a flavone that is present in Oroxylum indicum and in Scutellaria baicalensis. Because the root extracts of both plants have been shown to have anti-allergic effects, the authors investigated whether oroxylin A is likely to have beneficial effects on allergic asthma using female Balb/c mice and rat RBL-2H3 mast cells. Antigen-induced degranulation was measured in vitro by measuring β-hexosaminidase activity. A murine ovalbumin-induced allergic asthma model was used to test the in vivo efficacy of oroxylin A. Sensitization and challenge of ovalbumin induced allergic asthma responses, the accumulations of eosinophils and Th2 cytokine levels in bronchoalveolar lavage fluid and lung tissues. Oroxylin A administration decreased numbers of inflammatory cells, especially eosinophils, and reduced the expression and secretion of Th2 cytokines, including IL-4 and IL-13, in lung tissues and bronchoalveolar lavage fluid. Histologic studies showed oroxylin A reduced inflammatory signs and mucin production in lungs. These findings provide evidence that oroxylin A has potential use as an anti-allergic therapeutic.

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Section: Resultsmentioning

confidence: 99%

Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments

Lee

Kang

Park

et al. 2016

Biomol Ther (Seoul)

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“… Pericytes Secreting growth factors and ECM and absorbing soluble molecules into the cerebrospinal fluid 9 MMP, platelet-derived growth factor- β , (PDGF β ), IL-1 β , IL-6, TNF- α , ROS, NO 97. , 98. , 99.…”

Section: Discussionmentioning

confidence: 99%

“…Shikonin, extracted from lithospermum , is an active derivative of anthraquinone. Zhang et al 97 showed that shikonin inhibited the migration and invasion of glioma cells by inhibiting the expression of MMP-2 and MMP-9, which are secreted by microglia and can promote the proliferation and invasion of glioma 98 . Glial-to-mesenchymal transition proteins play a prominent role in tumor invasion, while shikonin can reduce the expression of these proteins and is a naphthoquinone with anti-tumor properties.…”

Section: Natural Products Regulating the Bbb Microenvironmentmentioning

confidence: 99%

Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy

Zhao

Chen

Liu

et al. 2017

Acta Pharmaceutica Sinica B

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Brain tumor incidence shows an upward trend in recent years; brain tumors account for 5% of adult tumors, while in children, this figure has increased to 70%. Moreover, 20%–30% of malignant tumors will eventually metastasize into the brain. Both benign and malignant tumors can cause an increase in intracranial pressure and brain tissue compression, leading to central nervous system (CNS) damage which endangers the patients' lives. Despite the many approaches to treating brain tumors and the progress that has been made, only modest gains in survival time of brain tumor patients have been achieved. At present, chemotherapy is the treatment of choice for many cancers, but the special structure of the blood–brain barrier (BBB) limits most chemotherapeutic agents from passing through the BBB and penetrating into tumors in the brain. The BBB microenvironment contains numerous cell types, including endothelial cells, astrocytes, peripheral cells and microglia, and extracellular matrix (ECM). Many chemical components of natural products are reported to regulate the BBB microenvironment near brain tumors and assist in their treatment. This review focuses on the composition and function of the BBB microenvironment under both physiological and pathological conditions, and the current research progress in regulating the BBB microenvironment by natural products to promote the treatment of brain tumors.

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“…P. japonicus has many pharmacologically active constituents, including petatewalide B, kaempferol, peteasitin, and quercetin. Petatewalide B is a novel sesquiterpene compound and is the most important active constituent of P. japonicus (13,14). Furthermore, sesquiterpenoids from P. japonicus play a key role in aging-related disorders, such as atherosclerosis, hyperlipidemia, Parkinson's disease, alzheimer's disease, and memory disorders (15,16).…”

Section: Petatewalide B Alleviates Oxygen-glucose Deprivation/reoxygementioning

confidence: 99%

“…The cells were washed twice with phosphate-buffered saline (PBS) and then cultured with oGd medium (glucose-free and serum-free dMeM) under hypoxic conditions (1% O 2 , 95% N2, and 5% CO 2 ) for 8 h at 37˚C, followed by quick reoxygenation (95% air and 5% CO 2 ). The medium was substituted with regular medium for 24 h. Petatewalide B was purified from P. japonicus leaves as previously described in another study (13). Petatewalide B was solubilized with dimethyl sulfoxide (dMSo) and pretreated with petatewalide B (5-40 µM) for 1 h before oGd/r treatment.…”

Section: Cell Culture and Establishment Of The Cell Model Of I/r Injurymentioning

confidence: 99%

Petatewalide B alleviates oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway

Park

Cho

et al. 2020

Mol Med Report

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neuronal injury is a common, and critical, occurrence in clinical ischemic strokes, and can cause irreversible brain damage. However, the precise pathological mechanisms underlying this condition and effective treatment remain unclear. increasing evidence shows that the nuclear factor erythroid 2-related factor 2 (nrf2)/activated protein kinase (AMPK) signaling pathway serves a significant role in neuronal injury and is involved in neuroprotection. The present study demonstrated that petatewalide B, the active constituent of Petasites japonicus, otherwise known as butterbur, can alleviate oxygen-glucose deprivation/reoxygenation (oGd/r)-induced neuronal death via the adenosine monophosphate-aMPK/glycogen synthase kinase (GSK)-3/β/nrf2/antioxidant response element (are) signaling pathways in human neuroblastoma SH-SY5Y cells. a neuronal injury model was established by depriving SH-SY5Y cells of oxygen and glucose for 8 h, followed by 24 h of reoxygenation (oGd/r). The results indicated that the oGd/r model exhibited reduced cell viability but increased lactate dehydrogenase (ldH) release, reactive oxygen species (roS) production and apoptosis. These were accompanied by increased levels of cleaved ParP, cleaved caspase-9, cleaved caspase-3, p53, Bax and p21, as well as decreased Bcl-2 levels. Treatment with petatewalide B was able to strengthen cell viability but reduced ldH release, roS production and the expression levels of apoptosis-related proteins. additionally, treatment with petatewalide B activated aMPK in the oGd/r-exposed SH-SY5Y cells and upregulated activation of the downstream transcription factor nrf2, which accompanied heme oxygenase 1 (Ho-1) and nad(P)H quinone dehydrogenase 1 (nQo1) expression. Furthermore, silencing aMPK, nrf2, Ho-1 and nQo1 expression inhibited petatewalide B's protective effect against apoptosis in the oGd/r-exposed SH-SY5Y cells. Therefore, petatewalide B protected human neuroblastoma cells against oGd/r-induced injury by downregulating apoptosis and oxidative stress via upregulation of the aMPK/nrf2 signaling pathway, suggesting that petatewalide B may be a prospective protector against neuronal injury, having possible therapeutic and medical implications.

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Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity

Cited by 22 publications

References 27 publications

Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments

Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments

Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy

Petatewalide B alleviates oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway

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