For ultra-high-resolution (UHR) squint spotlight airborne synthetic aperture radar (SAR), the severe range-azimuth coupling caused by squint mode and the spatial and frequency dependence of the motion error brought by ultra-wide bandwidth both make it difficult to obtain satisfactory imaging results. Although some autofocus methods for squint airborne SAR have been presented in the published literature, their practical applicability in UHR situations remains limited. In this article, a new 2D wavenumber domain autofocus method combined with the Omega-K algorithm dedicated to UHR squint spotlight airborne SAR is proposed. First, we analyze the dependence of range envelope shift error (RESE) and range defocus on the squint angle and then propose a new spectrum modification strategy, after which the spectrum transforms into a quasi-side-looking one. The accuracy of estimation and compensation can be improved significantly in this way. Then, the 2D phase error can be calculated with the 1D estimated error by the mapping relationship, and after that the 2D compensation is performed in the wavenumber domain. Furthermore, the image-blocking technique and range-dependent motion error compensation method are embedded to accommodate the spatial-variant motion error for UHR cases. Simulations are carried out to verify the effectiveness of the proposed method.