pFOE or pFTOE as an Early Marker for Impaired Peripheral Microcirculation in Neonates

Hoeller, Nina; Wolfsberger, Christina Helene; Pfurtscheller, Daniel; Binder‐Heschl, Corinna; Schwaberger, Bernhard; Urlesberger, Berndt; Pichler, Gerhard

doi:10.3390/children9060898

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…However, when comparing pFTOE of our present study [0.229 (0.213–0.246)] during the first “6 h time period” to pFOE ( 13 ) [0.35 (0.29–0.40)] at the same time period, higher values were observed for pFOE. Differences between and comparability of pFTOE and pFOE have already been investigated by Hoeller et al ( 11 ), who described the same trend of lower pFTOE values compared to pFOE values within the first few days after birth. This emphasizes that, even though both parameters describe the estimation of oxygen extraction in the tissue, pFTOE and pFOE cannot be used interchangeably.…”

Section: Discussionmentioning

confidence: 62%

“…pFTOE has been described in several studies in preterm neonates during the first 24 h after birth ( 8 – 10 ). A possible comparability of pFOE and pFTOE was investigated by Hoeller et al ( 11 ). This study described that pFOE and pFTOE show the same trend but cannot be equated, as pFOE values were found to be higher compared to pFTOE values.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral muscle fractional tissue oxygen extraction in stable term and preterm neonates during the first 24 h after birth

Wolfsberger,

Höller,

Baik-Schneditz

et al. 2023

Front. Pediatr.

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BackgroundPeripheral muscle fractional tissue oxygen extraction (pFTOE) represents the relative extraction of oxygen from the arterial to venous compartment, providing information about dynamic changes of oxygen delivery and oxygen consumption. The aim of the present study was to establish reference values of pFTOE during the first 24 h after birth in stable term and late preterm neonates.MethodsThe present study is a post-hoc analysis of secondary outcome parameters of prospective observational studies. Only stable neonates without infection, asphyxia and any medical support were eligible for our analysis to obtain normal values. For measurements of peripheral muscle tissue oxygenation index (pTOI) during the first 24 h after birth in term and preterm neonates, the NIRO200/NIRO200NX was used. Arterial oxygen saturation (SpO2) was obtained by pulse oximetry. pFTOE was calculated out of pTOI and SpO2: pFTOE = (SpO2-pTOI)/SpO2. Measurements of neonates were stratified into four groups according to their respective measurement time point (6 h periods) after birth. Term and preterm neonates were analyzed separately. Mean values of measurements during the first time period (0–6 h after birth) were compared to measurements of the following time periods (second = 7–12 h, third = 13–18 h, fourth = 19–24 h after birth).ResultsTwo-hundred-fourty neonates (55 term and 185 late preterm neonates) had at least one peripheral muscle NIRS measurements within the first 24 h after birth. Mean gestational age and birth weight were 39.4 ± 1.1 weeks and 3360 (2860–3680)g in term neonates and 34.0 ± 1.4 weeks and 2060 (1750–2350)g in preterm neonates, respectively. In term neonates pFTOE was 0.264 (0.229–0.300), 0.228 (0.192–0.264), 0.237 (0.200–0.274) and 0.220 (0.186–0.254) in the first, second, third and fourth time period. In preterm neonates pFTOE was 0.229 (0.213–0.246), 0.225 (0.209–0.240), 0.226 (0.210–0.242) and 0.238 (0.222–0.255) in the first, second, third and fourth time period. pFTOE did not show any significant changes between the time periods, neither in term nor in preterm neonates.ConclusionWe provide reference values of pFTOE for stable term and late preterm neonates within the first 24 h after birth, which were stable when comparing four 6-h periods. These normal values are of great need for interpreting pFTOE in scientific context as well as for potential future clinical applications.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Peripheral muscle fractional tissue oxygen extraction in stable term and preterm neonates during the first 24 h after birth

Wolfsberger,

Höller,

Baik-Schneditz

et al. 2023

Front. Pediatr.

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Reference ranges of peripheral‐muscle oxygenation in term neonates delivered by Caesarean section during immediate transition after birth

Wolfsberger,

Hoeller,

Baik‐Schneditz

et al. 2024

Acta Paediatrica

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AimTo establish reference ranges of peripheral‐muscle regional oxygen saturation (prSO2) and peripheral fractional tissue oxygen extraction (pFTOE) during the first 15 min after birth in stable term neonates.MethodsSecondary outcome parameters of prospective observational studies in healthy term neonates delivered by Caesarean section were analysed. prSO2 was measured on the right forearm using the INVOS 5100C monitor. pFTOE was calculated out of prSO2 and arterial oxygen saturation (SpO2). Centile charts (10th–90th) of prSO2 and pFTOE were defined during the first 15 min after birth.ResultsThree‐hundred‐five term neonates with a mean gestational age and birth weight of 39.0 ± 0.9 weeks and 3321 ± 454 g, respectively, were included. The 50th centiles of prSO2 were 39% (minute two), 52% (minute five), 71% (minute 10), and 73% (minute 15). The 50th centiles of pFTOE were 0.529 (minute two), 0.378 (minute five), 0.237 (minute 10), and 0.231 (minute 15).ConclusionReference ranges of prSO2 and pFTOE were established for term neonates delivered by Caesarean section during the immediate transition after birth. These reference ranges increase knowledge of physiological processes taking place immediately after birth and are necessary for possible future clinical applications.

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pFOE or pFTOE as an Early Marker for Impaired Peripheral Microcirculation in Neonates

Cited by 2 publications

References 15 publications

Peripheral muscle fractional tissue oxygen extraction in stable term and preterm neonates during the first 24 h after birth

Peripheral muscle fractional tissue oxygen extraction in stable term and preterm neonates during the first 24 h after birth

Reference ranges of peripheral‐muscle oxygenation in term neonates delivered by Caesarean section during immediate transition after birth

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